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BioProject ID	KAP220491
Sample Group Accession ID	KASG220881
Sample Title	Examination of the effects of viral doses on the lungs and spleen of K18-hACE2 transgenic mice by temporal transcriptional analyses
Description	Despite previous studies regarding the correlation between viral concentration and the manifestation of infection, it remains unclear whether exposure to a greater viral inoculum could determine a higher risk of developing severe COVID-19. Although intuitive, it has been challenging to obtain such dose-response data. In addition, the detailed immune responses to varying doses of virus infection are not yet completely understood in K18-hACE2 transgenic mice, in which hACE2 expression is controlled by the epithelial cell cytokeratin-18 (K18) promoter for efficient SARS-CoV-2 infection. Therefore, we aimed to evaluate the overall transcriptome profile of the lungs and spleen of K18-hACE2 transgenic mice intranasally inoculated with 1×10^5 and 1×10^2 PFU of SARS-CoV-2.
Sample Type	Model organism or animal sample
Registration Date	2022-10-31
Number of BioSamples	107
Number of Experiments	107

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KAD

BioProject ID	Sample Group Accession ID	KAD Accession ID	Registration Date	Platform	Strategy	Selection
KAP220491	KASG220881	KAD2200952	2022-10-31	ILLUMINA	RNA-Seq	Poly-A (Oligo-dT beads capture polyA tails)