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BioProject ID : KAP220399

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Project title : Development of panel classifying molecular subtypes to discover therapeutic targets in triple-negative breast cancer

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Name Jeong Joon
Organization Yonsei University Industry-Academic Cooperation Foundation
Department Department of Surgery

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Registration Date 2022-07-26

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Project Title Development of panel classifying molecular subtypes to discover therapeutic targets in triple-negative breast cancer
Relevance medical
Description 1. Construction of a clinical database with triple negative breast cancer cell line bank Clinical Research Information Service (CRIS) registration of 40 triple negative breast cancer cell lines and tumor tissue 2. Development of an analysis algorithm for molecular subtype determination Development of genetic screening and quantitative analysis algorithms for molecular subtype determination by simultaneously performing gene-expression profiling and nCounterassay in 100 cases of triple negative breast cancer. 3. Development of kit for molecular subtype classification of triple negative breast cancer using nCounterassay-optimized gene molecules Through the 1-2 years of research, the representative genes of triple negative breast cancer (Surgate Biomarker) are identified, and these genes are developed to be used in a kit form that is simple, reproducible and can be used in individual hospitals using nCounterassay 4. Molecular subtype classification is performed using the developed judgment kit. Molecular subtype classification is performed using a new 100 triple negative breast cancer tumor tissue. 5. Discovery of subtype targeted treatments through anti-cancer drug sensitivity tests An anticancer drug sensitivity test was performed in 100 triple negative breast cancer tumor tissues to discover the most effective targeted therapy with the best response for each subtype. 6. Kit optimization for molecular subtype classification of triple negative breast cancer using nCounterassay-optimized genetic factors A kit for determining molecular subtypes of triple negative breast cancer was finally developed through 3-4 years of research..
Project Data Type * Transcriptome or Gene Expression
Sample Scope * Multiisolate

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