KoNA

KoNA SEARCH

Browse BioProject

BioProject ID : KAP220395

Project title : Identification and functional analysis of targeted therapeutic marker for malignant lymphoma

Submitter

**Submitter**
Submitter를 안내합니다.
Name	Ko Young Hyeh
Organization	SAMSUNG MEDICAL CENTER
Department	Department of Pathology

Date

**Date**
Date를 안내합니다.
Registration Date	2022-07-26

Project Design

**Project Design**
Project Design를 안내합니다.
NTIS Number	-
Project Title	Identification and functional analysis of targeted therapeutic marker for malignant lymphoma
Relevance	medical
Description	● Treatment of B-cell origins Treatment of refractory lymphoma and T-cell origin Treatment of refractory lymphoma by exome/transcriptome sequencing in tissue of refractory lymphoma to discover treatment refractory-related gene mutations ● Genetic mutations are identified in malignant lymphoma, and anti-cancer drug resistance-inducing genes are discovered. ● Targeted exome sequencing aimed at the discovered treatment refractory-related genes was analyzed and confirmed again in a number of lymphoma tissues, and proteins related to the gene were identified in tumor tissues to verify the clinical validity of treatment refractory factors. ● Conduct a prospective cohort study to proactively confirm the validity of the discovered factors and establish them as biomarkers that can predict treatment non-compliance, and establish a prognosis prediction model based on them. ● Verification of the possibility of the discovered factor as a candidate for treatment through correlation analysis with previously reported lymphoma-related factors. ● Establish a cell line that regulates the expression of Target gene and confirm changes in anti-cancer drug sensitivity ● Verification of anticancer drug resistance association using cell lines that regulate the expression of the target gene of the detected malignant lymphoma (cell cycle/apoptosis analysis) ● A functional study related to lymphoma carcinogenesis and anticancer drug resistance of new target genes in cell lines and animal models
Project Data Type *	Whole Genome sequencing
Sample Scope *	Multiisolate

Hierarchy

**Hierarchy**
Hierarchy를 안내합니다.
Umbrella Project	KAU200000

Publications

**Publications**
Publications를 안내합니다.
PubMed ID
DOI

Sample Group

BioSample Accession ID	Project Title	Sample Type	Registration Date
No Data

Submitter’s other BioProjects

Show

BioProject Accession ID	Project Title	Sample Scope	Project Data Type	Registration Date
KAP220397	Development of Diagnostic Methods for Diabetes in High Risk Population Using Genetic and Proteomic Approach	Multiisolate	Exome	2022-07-26
KAP220193	Identification and validation of predictive markers of epilepsy susceptibility and therapeutic response by development of genome data analysis technology optimized to multifactorial diseases	Multiisolate	Exome	2022-04-12
KAP220401	Development of genetic biomarkers for early diagnosis and personalized medicine of precocious puberty	Multiisolate	Whole Genome sequencing	2022-07-26
KAP220190	Development of open innovation analysis platform for clinical cancer genome data	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220200	Development of personalized diagnosis and therapeutics for dark matters using somatic mutations in patient-derived tumor xenograft models maintaining tumor microenvironment.	Multiisolate	Exome	2022-04-12
KAP220195	Diagnostics to predict the progression of diabetic nephropathy using urinary exosomal microRNA	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220189	Identification of somatic mutations in malformed brain inducing epilepsy and development of diagnostic technology by using next generation sequencing	Multiisolate	Exome	2022-04-12
KAP220185	Development of high performance multiplex diagnostic technique and its clinical validation for genomic biomarkers in lung cancer	Multiisolate	Targeted Locus (Loci)	2022-04-12
KAP220192	International collaborative study on cancer onset mechanism of of Lysosomal Storage Disorder(LSD) by using epigenome data	Multiisolate	Targeted Locus (Loci)	2022-04-12
KAP220194	Development of thyroid cancer diagnostic system and therapeutics based on integrative genomic-epigenomic analysis	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220199	Development of Pharmacogenomic Target Sequencing Panel and Its Application to Precision Medicine	Multiisolate	Targeted Locus (Loci)	2022-04-12
KAP220196	Breast cancer prognosis predictive gene selection and expression analysis	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220186	Production of sequencing data and the assessment of the performance of high-performance cancer genome analysis software for certification of their clinical application	Multiisolate	Whole Genome sequencing	2022-04-12
KAP220183	Data Center for Genomic Medicine	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220191	Establishment and validation of drug sensitivity and resistance prediction models using PDTX-derived cancer whole-exome and transcriptome sequencing	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220402	Microbiome-based intestinal environment improvement effect verification and correlation analysis with intestinal flora	Environment	Metagenome	2022-07-26
KAP220396	Identification of RNA variant-based subtypes and prognostic markers in liver cancers	Multiisolate	Epigenomics	2022-07-26
KAP220399	Development of panel classifying molecular subtypes to discover therapeutic targets in triple-negative breast cancer	Multiisolate	Transcriptome or Gene Expression	2022-07-26
KAP220188	Validation of predictive biomarker for regorafenib response in metastatic colorectal cencer	Multiisolate	Exome	2022-04-12
KAP220197	Identification and validation of personalized gastric cancer biomarkers with disabled drug response induced by copy number variations, gene expression alterations, and fusion genes elucidated by genome and transcriptome sequencing	Multiisolate	Exome	2022-04-12
KAP220398	Development of Pharmacogenomic Target Sequencing Panel and Its Application to Precision Medicine	Multiisolate	Targeted Locus (Loci)	2022-07-26
KAP220198	Development of high-precision and high-performance multiomics cancer genome analysis software for targeted therapeutics and certification for clinical application	Multiisolate	Whole Genome sequencing	2022-04-12
KAP220184	Identification and functional analysis of targeted therapeutic marker for malignant lymphoma	Multiisolate	Whole Genome sequencing	2022-04-12
KAP220400	Development of thyroid cancer diagnostic system and therapeutics based on integrative genomic-epigenomic analysis	Multiisolate	Transcriptome or Gene Expression	2022-07-26
KAP220395	Identification and functional analysis of targeted therapeutic marker for malignant lymphoma	Multiisolate	Whole Genome sequencing	2022-07-26

고객님께서 요청하신 내용을 처리중입니다.

잠시만 기다려주세요.

KoNA

Browse BioProject

Summary 내용시작

Submitter

Date

Project Design

Hierarchy

Publications

Relations 내용시작

Sample Group

Submitter’s other BioProjects