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Name	CHUNG HYEWON
Organization	Konkuk University school of Medicine
Department	Department of Ophthalmology

Date

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Registration Date	2023-11-30

Project Design

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NTIS Number	1711200893
Project Title	in vivo effect of RORb Gene Silencing
Relevance	medical
Description	The final goal of this study is to develop a new concept treatment for age-related macular degeneration (AMD), which causes intractable blindness, through the development of in vivo retinal cell conversion technology. By knocking down NRL and RORβ, which are key transcription factors for photoreceptor (PR) rod cell differentiation, which are concentrated in the central periphery of the macula, converting rods into cone-like cells (iCPR), improving central vision and preventing rod cell death. It is intended to establish a direct cross-differentiation technology in vivo that can mitigate.
Project Data Type *	Transcriptome or Gene Expression
Sample Scope *	Single cell

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Umbrella Project	-

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