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BioProject ID : KAP220131

Project title : Drug target validation using transcriptome and the CRISPR/Cas9 systems

Submitter

**Submitter**
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Name	Kim Mi Rang
Organization	Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Department	Personalized Genomic Medicine Research Center

Date

**Date**
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Registration Date	2022-01-17

Project Design

**Project Design**
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NTIS Number	1711081523
Project Title	Drug target validation using transcriptome and the CRISPR/Cas9 systems
Relevance	medical
Description	To verify the transcriptome-based validity of candidate drugs / compounds derived from comparative analysis of transcripts and published large-scale drug-transcriptome data using next-generation sequencing in various disease models, and establish an efficient verification technique of CRISPR system-based drug action points.
Project Data Type *	Epigenomics,Transcriptome or Gene Expression
Sample Scope *	Synthetic

Hierarchy

**Hierarchy**
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Umbrella Project	KAU200000

Publications

**Publications**
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PubMed ID
DOI

Sample Group

BioSample Accession ID	Project Title	Sample Type	Registration Date
KASG220169	Transcriptome of lung cancer cell	Human sample	2022-03-03
KASG220168	Transcriptome & Epigenome of pancreatic islets of Prmt1 KO mouse	Model organism or animal sample	2022-01-17
KASG220170	Transcriptome & epigenome analysis of ceritinib resistant lung cancer cells	Human sample	2022-01-17

Submitter’s other BioProjects

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BioProject Accession ID	Project Title	Sample Scope	Project Data Type	Registration Date
KAP220356	Investigation of association between gut microbiota and type 2 diabetes	Multiisolate	Whole Genome sequencing,Transcriptome or Gene Expression	2022-07-05
KAP220279	Generation of epigenome/transcriptome data and biomarker discovery of diffuse type gastric cancer	Multiisolate	Transcriptome or Gene Expression	2022-04-28
KAP220130	Development of novel microbiome-driven therapies based on the meta-omics analysis	Monoisolate	Transcriptome or Gene Expression	2022-01-17
KAP220133	Development of YOBMT (Your Own Blended Microbiome Therapeutics) in metabolic/immune disorders	Environment	Metagenome	2022-01-17
KAP220131	Drug target validation using transcriptome and the CRISPR/Cas9 systems	Synthetic	Epigenomics,Transcriptome or Gene Expression	2022-01-17
KAP220358	Development of a pathogen control platform based on multiple interactions among enteric pathogens, symbiotic microbiome and host: from the perspectives of symbiotic microbiome	Multiisolate	Metagenome	2022-07-05
KAP220132	microRNAs profiling of ADPKD mouse model for novel therapeutic targets	Monoisolate	Transcriptome or Gene Expression	2022-01-17
KAP220357	Genomics-based drug response prediction technologies in refractory cancers	Multiisolate	Transcriptome or Gene Expression	2022-07-05
KAP220361	Epigenome/transcriptome-based immune profiling for the prediction of cancer immunotherapy against lung cancer	Multiisolate	Whole Genome sequencing	2022-07-05
KAP220134	Proteogenomics analysis and mechanism study to develop precision medicine for treatment-resistant pancreatic cancer	Multiisolate	Phenotype/Genotype,Transcriptome or Gene Expression	2022-01-17
KAP220359	Development of a prediction system for precision treatment of colorectal cancer by pharmacotranscriptome analysis of organoids	Multiisolate	Transcriptome or Gene Expression	2022-07-05
KAP220135	Proteogenomic analyses for developments of gastric cancer companion diagnostics and for targeted therapeutics candidates for refractory cancers	Multiisolate	Phenotype/Genotype,Transcriptome or Gene Expression	2022-01-17
KAP220362	Establishment of integrated RNome data and novel mechanisms for chronic liver disease	Monoisolate	Transcriptome or Gene Expression	2022-07-05
KAP220366	Discovery and functional study of target genes of natural and climacteric mouse skin aging model	Monoisolate	Transcriptome or Gene Expression	2022-07-05
KAP220136	Proteogenomics analysis and mechanism study to develop precision medicine for treatment-resistant pancreatic cancer	Multiisolate	Phenotype/Genotype,Transcriptome or Gene Expression	2022-01-17
KAP220364	Development of genomics-based therapeutic strategy targeting natural and climacteric aging in human skin	Multiisolate	Transcriptome or Gene Expression	2022-07-05
KAP220369	Development of targeting proteogenomic technology for refractory cancer treatment	Multiisolate	Whole Genome sequencing	2022-07-05
KAP220367	driver pathway prediction with disease related genome annotation	Multiisolate	Whole Genome sequencing	2022-07-05
KAP220363	Identification of diagnostic markers for chronic liver diseases by analyzing changes in chromatin remodeling patterns	Multiisolate	Whole Genome sequencing	2022-07-05
KAP220127	Development of a pathogen control platform based on multiple interactions among enteric pathogens, symbiotic microbiome and host: from the perspectives of enteric pathogens	Environment	Metagenome	2022-01-17
KAP220129	Disease research using fission yeast gene deletion library and next-generation sequencing (NGS) method	Monoisolate	Whole Genome sequencing	2022-01-17
KAP220128	Genome based Personal Medicine for Korean Rare Developmental Disease	Multiisolate	Exome	2022-01-17
KAP220365	Drug target identification using yeast deletion library	Multiisolate	Whole Genome sequencing,Epigenomics,Transcriptome or Gene Expression	2022-07-05
KAP220368	Development of bioinformatics platform of microbial community analysis for Korean patients with metabolic/immune disorders	Multiisolate	Metagenome	2022-07-05
KAP220360	Development of a prediction system for personalized treatment for colorectal cancer by pharmacoepigenomic analysis of organoids	Multiisolate	Whole Genome sequencing,Epigenomics	2022-07-05

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Submitter

Date

Project Design

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Publications

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Sample Group

Submitter’s other BioProjects