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Name	Kim Hyeran
Organization	Korea Research Institute of Bioscience and Biotechnology
Department	Plant Systems Engineering Research

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Registration Date	2022-04-26

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NTIS Number	-
Project Title	Analysis of genomic information of marine aquatic organisms and establishment of the foundation for utilization (R&D)
Relevance	environmental
Description	"○ Establishment of standard genomes of 70 species of marine aquatic organisms - 20 marine animals, 15 marine plants, 12 marine organisms, 23 marine microorganisms or more ○ Establishment of useful genes based on genomic information of marine aquatic organisms - Securing useful genes based on genomes of marine animals, plants, aquatic organisms, and microorganisms - Discovery of useful genes for antibiotic resistance based on metagenomes in marine marine life ○ Management and operation of genomic information of marine aquatic organisms - Establishment, Operation and Advancement of Integrated System for Registration and Utilization of Genetic Information - Enhancement of Utilization Value by Linkage between Real Resource Information and Genome Information of Marine Fishery Life ○ Training professionals in the production, analysis, management, and utilization of marine aquatic organisms ○ Establishment of a standardized system for utilizing genomic information of marine aquatic organisms - Resourceization and Industrial Utilization of Genetic Information in Marine Fisheries Organisms - Open and provide public information on science and technology centered on the utilization of genomic information of marine aquatic organisms - Processing and Visualization of Genetic Information of 40 Marine Fishery Species - Construction of the Antibiotic Resistance Metagenome DB for Marine Fishery ○ Utilization of genomic information of marine aquatic organisms - Development of Photogenetic System for Photoreceptors Based on Newly Borrowed Photoreceptors from Marine Plants to Regulate the Signaling of Animal Cell Lines to Light - Development of Healthcare and Regenerative Medical Materials Based on Genome Information - Development of Customized Material Screening System Based on Genetic Information - Select useful marine microorganisms by applying an efficient genome scanning method - Exploring Infinite BGCs through Omix Information Analysis of Marine Microorganisms - Activating or expressing BGC using synthetic biological techniques to discover new bioactive substances - Development of leading materials through derivative synthesis/activity optimization/volume production by developing a technology capable of structural transformation of functional physiological active substances based on synthetic biology - Development of a tool for analyzing antibiotic resistance genes (Resistome) in Jeju Island fish farms based on meta-genetics ○ Securing genetic structures/information on 17 marine animals and 10 strategic species ○ A Study on the Key Principles of Evolution through Comparative Genetic Analysis of Marine Animals ○ Functional analysis of marine animal gene groups in response to changes in the marine environment (salinity, water temperature, pH) ○ Establishment of marine life sovereignty through the detoxification of marine animal genomes on Dokdo ○ Establishment of standard genomes through genomic detoxification of 20 marine plants ○ Research on gene search and application related to bioactive substances in marine plants ○ Exploring useful genes and studying the usefulness of marine plants ○ Development of useful genetic markers related to the characteristics of marine organisms and their economic characteristics ○ Development of useful gene functions and establishment of a data platform specializing in marine life ○ Discover functional biomaterials based on genomic big data ○ Comparative genomic analysis based on marine organisms ○ Integrated management of genetic data and analysis results of marine aquatic organisms ○ Securing genomic information of various marine and fishery organisms at home and abroad ○ Establishment of research results database and big data analysis-based service for utilizing genomic information ○ Development of specialized education programs and conducting education and training ○ Establishment of the basis for analysis related to genomes of major marine aquatic organisms ○ 40 species of marine marine life, assembly notification ○ Establishment of Genome Browser of 40 marine and marine organisms through visualization of genomic information ○ Discovery of more than five new phytochrome candidate genes for marine birds ○ Establishment of sterile strains and development of transformation tools for ash and silver flagellates ○ Biochemical Functional Analysis of Phytochrome Derived from Ash and Silver flagellates and Cytogenetic Characteristics Using a Heterologus Expression System ○ Development of photogenetic system based on marine animal cell cycle ○ Establishment of the standard genomic information of Amur starfish ○ Development of healthcare and regenerative medical materials based on genomic information (Octopus, Dolgi sea cucumber, Amur starfish) - Development of materials related to cognitive function improvement, thrombolysis and hemostasis, liver, nerve regeneration, and metabolic function control ○ Development of customized material screening system based on genomic information (Octopus, Dolgi sea cucumber, Amur starfish) - Development of Material Screening System for Regenerative Medical and Metabolic Function Control ○ Detoxification of pathogenic (4) and standard (20) marine microorganism electric field genomes other than useful microorganisms (40 types) ○ Obtain a library of biologically active substances such as large-capacity dielectric/transcriptional/metabolism and bioinformatics ○ Development of the efficient expression activation system and heterogeneous expression cell plant of giant BGC derived from marine microorganisms ○ Development of a new biological active substance production system based on synthetic biology and investigation of the production and structure of new biological active substances (over 28 types) ○ Discovery of high functional physiologically active substances through activity evaluation (7 or more types) ○ Establishment of source technology for structural deformation of synthetic biological active substances and derivation of leading substances for follow-up research and development through derivative synthesis/active optimization/volume production (at least one type) ○ Establishment of a database of antibiotic resistance genes and identification of resistance mechanisms in the marine fisheries ○ Research on gene discovery and mechanisms with improved efficiency ○ Verification and activity screening of identified genes: Genetic function analysis by analyzing the relationship between genotypes and phenotypes ○ Quantitative analysis of seasonal antibiotic resistance genes based on SmartChip in Jeju fish farms ○ Establishment of database of antibiotic resistance genes and plasmids in Jeju Island fish farms ○ Development of a kit for monitoring antibiotic resistance genes using a database ○ Use as a standard gene for marine life ○ Use as the basis for claiming biological sovereignty over domestic and foreign biological resources ○ Presenting the possibility of industrialization using marine bio-materials ○ Development of various follow-up studies on marine life ○ Development of sophisticated genomic analysis technology with marine genome field research technology ○ Improving the possibility of industrialization of marine animal functional genes by discovering new functional genes ○ Contribute to the development of strategies for responding to changes in biological resources due to changes in the marine environment ○ Contribute to the conservation of marine ecosystems and the establishment of strategies for restoration of damaged ecosystems ○ Presenting the possibility of industrialization of genetic resources through the discovery of specific useful genes for marine life ○ Development of new breeding technology based on genomic information and securing genetic resources for marine life to secure the source technology of the next generation fisheries industry ○ Providing academic and industrial application-based technologies for major aquaculture and aquatic life resources through completion of standard genomes and establishment of genomic data platforms for aquatic life ○ Accelerated research on the improvement of aquaculture varieties by searching for useful genes and genetic markers for the purpose of major economic traits ○ Creating new industries by developing biomaterials using genomic big data ○ Promote follow-up research on genomes by providing services based on various analysis results ○ Securing the foundation for discovering useful genes related to marine marine life based on the notation work of genomic information ○ Visualize processed genomic information to increase access to genetic information to biologists who are not familiar with genetic information analysis, thereby accelerating related industries and research ○ Lead in the field of research on borrowed photoreceptors derived from algae ○ Securing phytochrome-based medical and material industries ○ Evaluation of safety and toxicity of developed materials and commercialization in connection with companies Lead the marine bio industry using the ○ material screening system and discover additional customized materials ○ Presentation of R&D model for marine bio-industrialization using genomic information ○ Useful marine microorganism genomic information to overcome the big gap between research on physiologically active marine natural substances and research on new drug development, efficiently and economically connecting infrastructure and development technologies ○ The creation of a new pharmacophore causes high value-added economic effects along with the development of new drug-related industries following the development of new drug leading substances. ○ Utilization of marine microorganism genomic information, provision of examples of new drug development, and establishment of a foundation for activation ○ Find useful genes of ovipotent microorganisms and provide a basis for their utilization of functional genes through functional screening ○ Systematic screening of resistance genes in various environments and research on propagation mechanisms are used as important information for understanding human resistance problems ○ Propose a more accurate method of monitoring antibiotic resistance genes by identifying trends in antibiotic resistance microorganisms in fish farms ○ Contribute to environmental protection in and out of fish farms by reducing antibiotic-resistant microorganisms and reducing the emission of antibiotic-resistant genes In conclusion, ○ The performance of genomic information infrastructure developed in this project is used as a source technology in industries and research fields such as new materials, useful ingredients, new drugs, bioenergy, environmental purification, fisheries, and new variety development ○ Used to establish data on securing genetic level sovereignty of marine marine marine species cultivated, farmed, inhabited and utilized in Korea ○ The useful genes developed through this project act as intellectual property rights ○ In particular, the genomic information infrastructure of strategic species is the effect of building infrastructure for the development of new high-performance marine varieties."
Project Data Type *	Whole Genome sequencing
Sample Scope *	Multiisolate

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