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BioProject ID : KAP220197

Project title : Identification and validation of personalized gastric cancer biomarkers with disabled drug response induced by copy number variations, gene expression alterations, and fusion genes elucidated by genome and transcriptome sequencing

Submitter

**Submitter**
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Name	Han-Kwang Yang
Organization	Seoul National University Research and development business foundation
Department	Seoul National University Research and development business foundation

Date

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Registration Date	2022-04-12

Project Design

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NTIS Number	-
Project Title	Identification and validation of personalized gastric cancer biomarkers with disabled drug response induced by copy number variations, gene expression alterations, and fusion genes elucidated by genome and transcriptome sequencing
Relevance	medical
Description	"""□ Based on the previously secured Korean gastric cancer genomic and transcriptional data and newly tested gastric cancer tissue genomic and transcriptional data, Korean specific gastric cancer biomarker candidates are selected through integrated system biology and bioinformation analysis. ○ Establish a database for single nucleotide polymorphism, replication water mutation, gene fusion, and gene expression by organizing Korean gastric cancer genomes and transcriptional data. ○ Using biological informatics and system biology techniques, Korean specific gastric cancer biomarkers are selected. ○ Using various open-source databases, information on the possibility of carcinogenesis for genes that have undergone replication, gene fusion, and overexpression is summarized. □Invitro/in vivo verification of Korean specific gastric cancer biomarker candidates ○Tumor production performance and metastatic ability of gastric cancer biomarker candidate genes are verified in cell lines ○Verification of tumor production and metastatic ability of gastric cancer biomarker candidate genes in animal models □ Discovering personalized gastric cancer treatment biomarkers through drug responsiveness (sensitivity/side effects) investigation of Korean specific gastric cancer biomarkers candidates ○ The cell line investigates the sensitivity and side effects of anticancer drugs in gastric cancer biomarker candidate genes. ○Discovered gastric cancer biomarkers for personalized treatment through drug reactivity experiments and integrated analysis of information collected from open source databases."
Project Data Type *	Exome
Sample Scope *	Multiisolate

Hierarchy

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Umbrella Project	KAU200000

Publications

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PubMed ID
DOI

Sample Group

BioSample Accession ID	Project Title	Sample Type	Registration Date
KASG220279	Discovery and verification of personalized gastric cancer biomarkers through genomic transcriptome sequencing-based copy number mutation, expression abnormality, and fusion gene analysis affecting drug response	Human sample	2022-04-12
KASG220274	Discovery and verification of personalized gastric cancer biomarkers through genomic transcriptome sequencing-based copy number mutation, expression abnormality, and fusion gene analysis affecting drug response	Human sample	2022-04-12

Submitter’s other BioProjects

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BioProject Accession ID	Project Title	Sample Scope	Project Data Type	Registration Date
KAP220397	Development of Diagnostic Methods for Diabetes in High Risk Population Using Genetic and Proteomic Approach	Multiisolate	Exome	2022-07-26
KAP220193	Identification and validation of predictive markers of epilepsy susceptibility and therapeutic response by development of genome data analysis technology optimized to multifactorial diseases	Multiisolate	Exome	2022-04-12
KAP220401	Development of genetic biomarkers for early diagnosis and personalized medicine of precocious puberty	Multiisolate	Whole Genome sequencing	2022-07-26
KAP220190	Development of open innovation analysis platform for clinical cancer genome data	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220200	Development of personalized diagnosis and therapeutics for dark matters using somatic mutations in patient-derived tumor xenograft models maintaining tumor microenvironment.	Multiisolate	Exome	2022-04-12
KAP220195	Diagnostics to predict the progression of diabetic nephropathy using urinary exosomal microRNA	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220189	Identification of somatic mutations in malformed brain inducing epilepsy and development of diagnostic technology by using next generation sequencing	Multiisolate	Exome	2022-04-12
KAP220185	Development of high performance multiplex diagnostic technique and its clinical validation for genomic biomarkers in lung cancer	Multiisolate	Targeted Locus (Loci)	2022-04-12
KAP220192	International collaborative study on cancer onset mechanism of of Lysosomal Storage Disorder(LSD) by using epigenome data	Multiisolate	Targeted Locus (Loci)	2022-04-12
KAP220194	Development of thyroid cancer diagnostic system and therapeutics based on integrative genomic-epigenomic analysis	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220199	Development of Pharmacogenomic Target Sequencing Panel and Its Application to Precision Medicine	Multiisolate	Targeted Locus (Loci)	2022-04-12
KAP220196	Breast cancer prognosis predictive gene selection and expression analysis	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220186	Production of sequencing data and the assessment of the performance of high-performance cancer genome analysis software for certification of their clinical application	Multiisolate	Whole Genome sequencing	2022-04-12
KAP220183	Data Center for Genomic Medicine	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220191	Establishment and validation of drug sensitivity and resistance prediction models using PDTX-derived cancer whole-exome and transcriptome sequencing	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220402	Microbiome-based intestinal environment improvement effect verification and correlation analysis with intestinal flora	Environment	Metagenome	2022-07-26
KAP220396	Identification of RNA variant-based subtypes and prognostic markers in liver cancers	Multiisolate	Epigenomics	2022-07-26
KAP220399	Development of panel classifying molecular subtypes to discover therapeutic targets in triple-negative breast cancer	Multiisolate	Transcriptome or Gene Expression	2022-07-26
KAP220188	Validation of predictive biomarker for regorafenib response in metastatic colorectal cencer	Multiisolate	Exome	2022-04-12
KAP220197	Identification and validation of personalized gastric cancer biomarkers with disabled drug response induced by copy number variations, gene expression alterations, and fusion genes elucidated by genome and transcriptome sequencing	Multiisolate	Exome	2022-04-12
KAP220398	Development of Pharmacogenomic Target Sequencing Panel and Its Application to Precision Medicine	Multiisolate	Targeted Locus (Loci)	2022-07-26
KAP220198	Development of high-precision and high-performance multiomics cancer genome analysis software for targeted therapeutics and certification for clinical application	Multiisolate	Whole Genome sequencing	2022-04-12
KAP220184	Identification and functional analysis of targeted therapeutic marker for malignant lymphoma	Multiisolate	Whole Genome sequencing	2022-04-12
KAP220400	Development of thyroid cancer diagnostic system and therapeutics based on integrative genomic-epigenomic analysis	Multiisolate	Transcriptome or Gene Expression	2022-07-26
KAP220395	Identification and functional analysis of targeted therapeutic marker for malignant lymphoma	Multiisolate	Whole Genome sequencing	2022-07-26

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