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BioProject ID : KAP220195

Project title : Diagnostics to predict the progression of diabetic nephropathy using urinary exosomal microRNA

Submitter

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Name	LEE DAE HO
Organization	Gachon University Gil Hospital
Department	Department of Endocrinology and Metabolism

Date

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Registration Date	2022-04-12

Project Design

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NTIS Number	-
Project Title	Diagnostics to predict the progression of diabetic nephropathy using urinary exosomal microRNA
Relevance	medical
Description	- Training set for evaluating the clinical effectiveness of miRNA markers (n=150): patients with retroactive eGFR trajectory analysis among type 2 diabetes patients with progressors, non-progressors, and health controls secured - Test set (n=90): Proactive eGFR trajectory follow-up (12-months) in patients with type 2 diabetes after retroactive cohort establishment and re-classification and marker reproducibility verification 4) Construction of urine exosome miRNA analysis platform - Small RNA (sRNA) isolation and library construction from urine exosomes - sRNA sequencing via MiSeq (Ilumina) platform - miRNA profiling based on sRNA sequencing information - discovery of bioinformatics-based biomarkers 5) Clinical Usefulness Evaluation of Biomarkers for Predicting Progression of Diabetic Neuropathy Validation of urine exosome miRNA biomarkers for Progressor identification - Urine exosome miRNA NGS analysis with training set (n=150) - Urine exosomes targeted qPCR for training set (20 people per group) - Clinical Validation of Biomarkers Related to Diabetic Neuropathy and Selection of Final Biomarkers 6) Verification of reproducibility of diagnostic methods based on urine exosome miRNA analysis in prospective cohorts - Urine exosome miRNA NGS analysis in prospective cohort (n=90) - Urine exosome targeted qPCR for prospective cohort (20 persons per group) 7) Data Filing for Development of Progressive Diabetes Prediction Algorithm and Reporting to the Ministry of Food and Drug Safety
Project Data Type *	Transcriptome or Gene Expression
Sample Scope *	Multiisolate

Hierarchy

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Umbrella Project	-

Publications

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Sample Group

BioSample Accession ID	Project Title	Sample Type	Registration Date
KASG220278	microRNA biomarkers in type 2 diabetes	Human sample	2022-04-12
KASG220271	microRNA biomarkers in type 2 diabetes	Human sample	2022-04-12

Submitter’s other BioProjects

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BioProject Accession ID	Project Title	Sample Scope	Project Data Type	Registration Date
KAP220397	Development of Diagnostic Methods for Diabetes in High Risk Population Using Genetic and Proteomic Approach	Multiisolate	Exome	2022-07-26
KAP220193	Identification and validation of predictive markers of epilepsy susceptibility and therapeutic response by development of genome data analysis technology optimized to multifactorial diseases	Multiisolate	Exome	2022-04-12
KAP220401	Development of genetic biomarkers for early diagnosis and personalized medicine of precocious puberty	Multiisolate	Whole Genome sequencing	2022-07-26
KAP220190	Development of open innovation analysis platform for clinical cancer genome data	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220200	Development of personalized diagnosis and therapeutics for dark matters using somatic mutations in patient-derived tumor xenograft models maintaining tumor microenvironment.	Multiisolate	Exome	2022-04-12
KAP220195	Diagnostics to predict the progression of diabetic nephropathy using urinary exosomal microRNA	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220189	Identification of somatic mutations in malformed brain inducing epilepsy and development of diagnostic technology by using next generation sequencing	Multiisolate	Exome	2022-04-12
KAP220185	Development of high performance multiplex diagnostic technique and its clinical validation for genomic biomarkers in lung cancer	Multiisolate	Targeted Locus (Loci)	2022-04-12
KAP220192	International collaborative study on cancer onset mechanism of of Lysosomal Storage Disorder(LSD) by using epigenome data	Multiisolate	Targeted Locus (Loci)	2022-04-12
KAP220194	Development of thyroid cancer diagnostic system and therapeutics based on integrative genomic-epigenomic analysis	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220199	Development of Pharmacogenomic Target Sequencing Panel and Its Application to Precision Medicine	Multiisolate	Targeted Locus (Loci)	2022-04-12
KAP220196	Breast cancer prognosis predictive gene selection and expression analysis	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220186	Production of sequencing data and the assessment of the performance of high-performance cancer genome analysis software for certification of their clinical application	Multiisolate	Whole Genome sequencing	2022-04-12
KAP220183	Data Center for Genomic Medicine	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220191	Establishment and validation of drug sensitivity and resistance prediction models using PDTX-derived cancer whole-exome and transcriptome sequencing	Multiisolate	Transcriptome or Gene Expression	2022-04-12
KAP220402	Microbiome-based intestinal environment improvement effect verification and correlation analysis with intestinal flora	Environment	Metagenome	2022-07-26
KAP220396	Identification of RNA variant-based subtypes and prognostic markers in liver cancers	Multiisolate	Epigenomics	2022-07-26
KAP220399	Development of panel classifying molecular subtypes to discover therapeutic targets in triple-negative breast cancer	Multiisolate	Transcriptome or Gene Expression	2022-07-26
KAP220188	Validation of predictive biomarker for regorafenib response in metastatic colorectal cencer	Multiisolate	Exome	2022-04-12
KAP220197	Identification and validation of personalized gastric cancer biomarkers with disabled drug response induced by copy number variations, gene expression alterations, and fusion genes elucidated by genome and transcriptome sequencing	Multiisolate	Exome	2022-04-12
KAP220398	Development of Pharmacogenomic Target Sequencing Panel and Its Application to Precision Medicine	Multiisolate	Targeted Locus (Loci)	2022-07-26
KAP220198	Development of high-precision and high-performance multiomics cancer genome analysis software for targeted therapeutics and certification for clinical application	Multiisolate	Whole Genome sequencing	2022-04-12
KAP220184	Identification and functional analysis of targeted therapeutic marker for malignant lymphoma	Multiisolate	Whole Genome sequencing	2022-04-12
KAP220400	Development of thyroid cancer diagnostic system and therapeutics based on integrative genomic-epigenomic analysis	Multiisolate	Transcriptome or Gene Expression	2022-07-26
KAP220395	Identification and functional analysis of targeted therapeutic marker for malignant lymphoma	Multiisolate	Whole Genome sequencing	2022-07-26

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Submitter’s other BioProjects