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Submitter

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Name	Kim Tae-Min
Organization	Academy Industry Cooperation Foundation Catholic of Korea
Department	Academy Industry Cooperation Foundation Catholic of Korea

Date

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Registration Date	2022-04-12

Project Design

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NTIS Number	-
Project Title	Establishment and validation of drug sensitivity and resistance prediction models using PDTX-derived cancer whole-exome and transcriptome sequencing
Relevance	medical
Description	"○Establishment of an analytical system for excavation of somatic mutations (point mutations and indels) by exom-based sequencing of PDTX transplanted tissue (F2) originating from cancer patient tissue and analysis of changes in the number of DNA copies of the exom-based tissue. ○Establishment of an analysis system for gene expression profiling by transcriptional sequence determination of cancer tissues, discovery of alternative splicing such as fusion genes, and verification of exom sequencing mutants ○Established an integrated multi-omics-based functional analysis system for various types of excavated exome and transcript catalogs ○Discovery of genetic variation by PDTX-specific analytical model including Xenosequencing filtering technology ○Establishment of multi-omics-based functional analysis technology utilizing public dielectric resources and databases ○Retained somatic genetic mutations --Validation and complementation of miraculous gene signatures that can predict the efficacy and resistance development of targeted therapeutic agents by analysis of an integrated database of clinical factors ○Cross-validation within the cohort and accuracy verification of the predictive model with the added patient cohort ○Marker selection / panelization for clinical realization of the final model and functional analysis of markers selected in collaboration with the first detail"
Project Data Type *	Transcriptome or Gene Expression
Sample Scope *	Multiisolate

Hierarchy

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Umbrella Project	-

Publications

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