We conclude that human autoantigen pericentriolar material (PCM1)-JAK2 is a novel, recurrent fusion gene in hematologic malignancies.     ///    Reverse transcription-PCR and fluorescence in situ hybridization confirmed the fusion in this case and also identified PCM1-JAK2 in the six other t(8;9) patients.     ///    Reciprocal JAK2-PCM1 mRNA was not detected in any patient.     ///    Patients with PCM1-JAK2 disease are attractive candidates for targeted signal transduction therapy.. 