Synovial sarcoma is an aggressive soft tissue tumor characterized by a chromosomal translocation between chromosome 18 and X, generating oncoproteins such as SYT-SSX1 and SYT-SSX2.     ///    SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein..     ///    "Here we show that SYT-SSX1 leads to up-regulation of NCOA3, a protein critical for the formation of various cancers. "    ///    The molecular mechanism underlying the oncogenic potential of SYT-SSX1/2 is not clear.     ///    "SYT-SSX1 does so by increasing the sumoylation of NCOA3 through interaction with a SUMO E3 ligase, PIASy, as well as the sumoylation of NEMO. "