The most frequently identified fusion gene is TMPRSS2:ERG, which causes ERG protein overexpression in PCa cells.     ///    "To characterize ERG and TMPRSS2:ERG transcriptional activity of OPN, we focused on ETS binding sites (EBS) localized in conserved regions of the promoter. "    ///    "Moreover, stable transfection of prostate tumor cell lines by TMPRSS2:ERG upregulates endogenous OPN expression. "