Both reciprocal fusion transcripts, ETV6/FRK and FRK/ETV6, were expressed.     ///    "This report provides the first evidence that a SRC-like kinase gene, FRK fused with ETV6, could directly contribute to leukemogenesis by producing an oncoprotein, ETV6/FRK, with dual functions: constitutive activation of the ETV6/FRK tyrosine kinase and dominant-negative modulation of ETV6-mediated transcriptional repression.. "    ///    "Moreover, ETV6/FRK inhibited ETV6-mediated transcriptional repression in a dominant-negative manner. "    ///    The ETV6/FRK protein was shown to be constitutively autophosphorylated on its tyrosine residues.     ///    "ETV6/FRK could transform both Ba/F3 cells and NIH3T3 cells, which depended on its kinase activity. "    ///    "ETV6/FRK phosphorylated histones H2B and H4 in vitro to a greater extent than did FRK, suggesting it had elevated kinase activity. "    ///    "In ETV6/FRK, exon 4 of ETV6 was fused in-frame to exon 3 of FRK, producing a chimeric protein consisting of the entire oligomerization domain of ETV6 and the kinase domain of FRK. "