 The fusion gene AML1-ETO is the product of t(8;21)(q22;q22), one of the most common chromosomal translocations associated with acute myeloid leukemia.     ///    "The proliferation of AML1-ETO(+) cells was markedly reduced, and most of the cells eventually underwent apoptosis. "    ///    Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation..     ///    AML1-ETO is tightly and strongly induced upon tetracycline withdrawal.     ///    "Prior to the onset of apoptosis, we also studied the ability of AML1-ETO to modulate differentiation. "    ///    "These observations suggest a dichotomy in the functions of AML1-ETO: (i) reduction of granulocytic differentiation correlated with decreased expression of C/EBPalpha and (ii) growth arrest leading to apoptosis with decreased expression of CDK4, c-myc, and Bcl-2. "    ///    AML1-ETO expression altered granulocytic differentiation of U937T-A/E cells.     ///    RNase protection assays revealed that the amount of Bcl-2 mRNA was decreased after AML1-ETO induction. 