Consistent with the association with AML, the increased protein synthesis mediated by DEK-NUP214 is restricted to cells of the myeloid lineage.     ///    Our findings reveal a substantial increase in global protein synthesis in DEK-NUP214 expressing cells.     ///    "Analysis of potential mechanisms for regulating protein synthesis shows that expression of DEK-NUP214 correlates to the phosphorylation of the translation initiation protein, EIF4E. "    ///    "The mechanism by which the fusion protein DEK-NUP214 contributes to leukemia development has not been identified, and disruptions of normal cellular functions by DEK-NUP214 have previously not been described. "    ///    Identification of a novel and myeloid specific role of the leukemia-associated fusion protein DEK-NUP214 leading to increased protein synthesis..     ///    "In the present study, a novel effect of the DEK-NUP214 fusion protein is demonstrated. "