Our results suggest that the fusion gene SYT-SSX should be considered to play important role on SS cell growth via ERK pathway.     ///    "Meanwhile, down-regulation of SYT-SSX fusion gene expression would inhibit the proliferation of SS cell and the survival rate decreased (34.1%), while apoptotic rate increased (10.92%). "    ///    This study may be valuable for understanding the pathogenic role and molecular mechanism of the fusion gene SYT-SSX in synovial sarcoma through the proposed genome-wide approach.     ///    "In TMA stain assessment, SYT-SSX positive group with high ki-67 LI expressed more cyclin D1and CDK4 than the SYT-SSX negative group. "    ///    The mRNA level reduced over 90% caused by SYT-SSX specific siRNA.     ///    The effect of SYT-SSX and extracellular signal-regulated kinase (ERK) on cell proliferation in synovial sarcoma..     ///    "Furthermore, the research would open up the possibility of using SYT-SSX and ERK as a therapeutic target.. "    ///    "The protein level of ERK1/2, p-ERK, and cyclin D1 altered in same trend with expression of SYT-SSX. "    ///    We evaluated the whole genome expression in SYO-1 cells inhibited as a result of specific small interfering RNA for SYT-SSX. 