Transfection of p53/p21 fusion gene to Tca8113 cells could inhibit the tumor cell proliferation and clone formation in vitro, and make itself a potential fusion gene for the gene therapy of human oral squamous cell carcinoma..     ///    RT-PCR and Western blot demonstrated that it was the expression of exogenous p53/p21 fusion gene that led to the above results.     ///    RT-PCR and Western blot were used to demonstrate the expression of p53/p21 fusion gene.     ///    It was observed that p53/p21 fusion gene could inhibit clonal formation and proliferation of human oral carcinoma.     ///    [Cloning of p53/p21 fusion gene and it's inhibitory effect on the growth in Tca8113 cells]..     ///     To study the p53/p21 fusion gene as a potential fusion gene for the gene therapy of human oral squamous cell carcinoma.     ///    The recombinant plasmid pcDNA-p53/p21 was constructed by inserting the p53/p21 fusion gene into eukaryotic expression vector pcDNA3.1 and subsequently transfected into human oral squamous cell carcinoma cell line (Tca8113) with lipofectamine. 