One example is AML1-ETO, the most common translocation reported in acute myeloid leukemia (AML).     ///    Identification of AML1-ETO modulators by chemical genomics..     ///    "In addition to modulating the AML1-ETO signature, both classes induced evidence of differentiation, dramatically inhibited cell viability, and ultimately induced apoptosis via on-target activity. "    ///    "To identify AML1-ETO modulators, we screened a small molecule library using a chemical genomic approach. "    ///    The corticosteroids diminished AML1-ETO protein in AML cells in a proteasome- and glucocorticoid receptor-dependent manner. 