The identification of Scrib as an Sgt1-HSP90 client protein required for three-dimensional cell migration suggests that chaperone-mediated regulation of polarity protein stability and homeostasis is an unappreciated mechanism underlying dynamic rearrangements during morphogenesis..     ///    Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90..     ///    "Furthermore, reduced Scrib stability, following inhibition of Sgt1-HSP90, lowers the cellular abundance of the Scrib-?Pix-PAK complex. "