Cytogenetic abnormalities are commonly acquired during the course of disease and the most common is chromosomal translocation t(11;18)(q21;q21), which creates the API2-MALT1 fusion oncoprotein.     ///    "By effectively mimicking ligand-bound TNF receptor, API2-MALT1 promotes TRAF2-dependent ubiquitination of RIP1, which then acts as a scaffold for nucleating and activating the canonical NF-?B machinery. "    ///    "Thus, API2-MALT1 harnesses multiple unique pathways to achieve deregulated NF-?B activation. "    ///    "In this review, we highlight the most recent results characterizing these unique and diverse gain-of-function activities of API2-MALT1 and how they contribute to lymphomagenesis. "    ///    API2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysis..     ///    "Like NIK, LIMA1 represents a unique substrate for API2-MALT1 protease activity, but unlike NIK, its cleavage sets in motion a major NF-?B-independent pathway for promoting oncogenesis. "    ///    "Specifically, API2-MALT1 recruits and subverts multiple other signaling factors, including LIM domain and actin-binding protein 1 (LIMA1) and Smac/DIABLO. "    ///    Emerging data from our group and others have also detailed additional gain-of-function activities of API2-MALT1 that extend beyond NF-?B activation.     ///    "In this regard, API2-MALT1 recognizes NF-?B inducing kinase (NIK), the essential upstream regulator of non-canonical NF-?B, and cleaves it to generate a stable, constitutively active fragment. "