We identified five cases of Philadelphia positive subclones in AML occurring in coincidence with other genetic lesions: 1:220 patients with inv(16)/CBFB-MYH11 (0??5%), 2:272 AML cases with t(8;21)/RUNX1-RUNX1T1 (0??7%), 1:1029 NPM1-mutated AML (0??1%), and one patient with s-AML following MDS with a 5q-deletion. 