This translocation results in the RUNX1-RUNX1T1 fusion gene that produces a wide variety of alternative transcripts and influences the course of the disease.     ///    "Altogether, our results show that alternative splicing of the RUNX1-RUNX1T1 transcripts follows strict rules and that the power-law component of the fusion gene organization confers a high flexibility to this process. "    ///    The rules of combinatorics and splicing of exons in the RUNX1-RUNX1T1 transcripts are not known.     ///    "Here we show that the local exon combinatorics of the RUNX1-RUNX1T1 gene follows a power-law behavior and (i) the vast majority of exons has a low ECI, (ii) only a small part is represented by ""exons-hubs"" of splicing with very high ECI values, and (iii) it is scale-free and very sensitive to targeted skipping of ""exons-hubs"". "