Most cases harbor the (11;22) (q24;q12) chromosomal translocation that encodes the EWS/FLI oncoprotein.     ///    "The observation of microsatellites as transcriptional response elements for EWS/FLI suggest that these elements may not be ""junk"" after all.. "    ///    EWS/FLI is an aberrant ETS-type transcription factor that dysregulates a number of genes important in the development of Ewing's sarcoma.     ///    "Because EWS/FLI is the key oncoprotein in this tumor and ETS proteins are often dysregulated in various human cancers, Ewing's sarcoma serves as a useful paradigm for ETS-mediated oncogenesis. "    ///    "Microsatellites are EWS/FLI response elements: genomic ""junk"" is EWS/FLI's treasure.. "    ///    "We recently showed that EWS/FLI interacts with GGAA-microsatellites to regulate some of its target genes, including NR0B1, an EWS/FLI-regulated gene that is required for the oncogenic phenotype of Ewing's sarcoma. "