Thus, inhibition of ERK signaling pathway could be a potential strategy in treatment of NSCLC patients with EML4-ALK translocation..    ///    "Thus, inhibition of ERK signaling pathway could be a potential strategy in treatment of NSCLC patients with EML4-ALK translocation.. "    ///    "Here, for the first time, we showed that H1299 NSCLC cells stably expressing EML4-ALK acquire EMT phenotype, associated with enhanced invasive migration and increased expression of EMT-inducing transcription factors. "    ///    "However, the role of EML4-ALK in malignant transformation is not entirely clear."    ///    EML4-ALK induces epithelial-mesenchymal transition consistent with cancer stem cell properties in H1299 non-small cell lung cancer cells..     ///    "Moreover, we found that inhibition of ERK1/2 reversed EMT induced by EML4-ALK in H1299 cells. "    ///    "However, the role of EML4-ALK in malignant transformation is not entirely clear. "    ///    "Taken together, these results suggested that EML4-ALK induced ERK activation is mechanistically associated with EMT phenotype. "