The clinical characteristics of a 45-year-old Chinese female CML patient with e19a2 BCR/ABL1 transcript were described.     ///    This patient developed an acquired resistance associated with two p-BCR/ABL1 mutations (E255K and G250E) during treatment with imatinib.     ///    The ?-BCR/ABL1 mutation should be investigated after imatinib treatment failure.. 