The interaction of the AICD with the C-terminal phosphotyrosine-binding domain of Fe65 (Fe65-PTB2) regulates APP translocation, signalling and processing.     ///    "Human AICD and Fe65-PTB2 have been cloned, overproduced and purified in large amounts in Escherichia coli. "    ///    A complex of Fe65-PTB2 with the C-terminal 32 amino acids of the AICD gave well diffracting hexagonal crystals and data have been collected to 2.1 A resolution. 