The resultant NPM-RAR fusion protein blocks myeloid differentiation and leads to a leukemic phenotype similar to that caused by the t(15;17)(q22;q21) PML-RAR fusion.     ///    The contribution of the N-terminal 117 amino acids of NPM contained within NPM-RAR has not been well studied.     ///    This study identifies a novel mechanism through which NPM-RAR affects leukemogenesis..     ///    "Therefore, a proteomic analysis was conducted to identify novel NPM-RAR-associated proteins. "    ///    "Biologic assessment found that NPM-RAR expression impaired TNF-induced signaling through TRADD, blunting TNF-mediated activation of caspase-3 (CASP3) and caspase-8 (CASP8), to ultimately block apoptosis. "    ///    Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD.. 