INSERT INTO `ChimerPub_dump` VALUES ('10152', 'FLI1_EWSR1', '', 'FLI1', 'EWSR1', '11823984', '-51', 'ewing sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', 'Seq', 'This type of tumor is well characterized by recurrent chromosomal translocation such as t (11;22) (q24;q12) (EWSR1/FLI1) or t (21;22) (q22;q12) (EWSR1/ERG) and overexpression of MIC2/CD99 on tumor cell membrane. '), ('10153', 'FAP_LAMP', '', 'FAP', 'LAMP', '16061874', '-54', '', '', '', '', '', '', '', '', '', 'Dendritic cells transfected with mRNA encoding the FAP-LAMP fusion product stimulated enhanced CD4(+) and CD8(+) T-cell responses. '), ('10154', 'EWS_ERG', '', 'EWS', 'ERG', '15846078', '-59', 'fibrosarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Additionally through use of an antisense oligonucleotide for EWS-ERG in the W-ES EFT cell line, laminin beta3 protein was reduced coordinately with EWS-ERG fusion protein expression. '), ('10155', 'EWSR1_FLI1', '', 'EWSR1', 'FLI1', '26579494', '-82', 'ewing sarcoma', '', '', '', '', '', '', 'KB', 'Seq', 'OX40L transgenic Ewing sarcoma cells showed preserved expression of Ewing sarcoma-associated (anti)gens including lipase member I, cyclin D1 (CCND1), cytochrome P450 family member 26B1 (CYP26B1), and the Ewing sarcoma breakpoint region 1-friend leukemia virus integration 1 (EWSR1-FLI1) oncogene.    ///    \"OX40L transgenic Ewing sarcoma cells showed preserved expression of Ewing sarcoma-associated (anti)gens including lipase member I, cyclin D1 (CCND1), cytochrome P450 family member 26B1 (CYP26B1), and the Ewing sarcoma breakpoint region 1-friend leukemia virus integration 1 (EWSR1-FLI1) oncogene. \"'), ('10156', 'RUNX1_ETV6', 't(12;21)(p13;q22) / t(8;12;21)  / ', 'RUNX1', 'ETV6', '26711002', '265', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', ' The t(12;21)(p13;q22) ETV6-RUNX1 gene fusion is one of the most common chromosomal translocation in childhood acute lymphoblastic leukemia (ALL).     ///    \"Interestingly, the three-way translocation, including ETV6-RUNX1, was detected in five patients. \"    ///    Determination of ETV6-RUNX1 genomic breakpoint by next-generation sequencing.. '), ('10157', 'MTG16_AML1', 't(16;21)  / t(16;21)(q24;q22) / t(8;21)  / t(8;21) / ', 'MTG16', 'AML1', '9596646', '245', 'leukemia\r\r', '', '', '', '', '', '', '', '', 'Thus, the AML1-MTG16 gene fusion in t(16;21) leukemia results in the production of a protein that is very similar to the AML1-MTG8 chimeric protein..     ///    \"Although the reciprocal chimeric product, MTG16-AML1, was also detected in one of the t(16;21) patients, its protein product was predicted to be truncated. \"'), ('10158', 'TEL_AML1', 't(9;22)  / t(4;11) / t(12;21)(p13;q22) / t(12;21) / t(12;21)  / ', 'TEL', 'AML1', '9226156', '234', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', '', '', '', '', '', '', '', '', 'To investigate the frequency of the molecular equivalent of the t(12;21), the TEL/AML1 gene fusion, we have undertaken a prospective screening in the running German Berlin-Frankfurt-M?nster (BFM) and Italian Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) multicenter ALL therapy trials.     ///    Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials.     ///    A total of 342 children were investigated for the presence of TEL/AML1 fusion gene and 99 cases (28.9%) were positive.     ///    \"Whereas three of the TEL/AML1 positive cases (3.0%) have relapsed to date, 27 patients without TEL/AML1 rearrangement (11.1%) suffered from relapse. \"    ///    \"Based on this prospective analysis, we retrospectively evaluated the impact of TEL/AML1 in prognosis by identifying the subset of B-lineage ALL children enrolled in the closed German ALL-BFM-90 and Italian ALL-AIEOP-91 protocols who had sufficient material for analysis. \"    ///    DNA index was available for 59 of the 63 TEL/AML1 positive cases.     ///    \"The 63 cases positive for the TEL/AML1 chimeric products ranged in age between 1 and 12 years, and all but one showed CD10 and pre-B immunophenotype. \"    ///    The patients expressing the TEL/AML1 fusion mRNA appeared to have a better event-free survival (EFS) than the patients who lacked this chimeric product. '), ('10159', 'ITPR2_BCL6', 't(3;13)(q27;q31) / t(12;13)(p11;q31) / t(3;13) / t(12;13)  / ', 'ITPR2', 'BCL6', '22072491', '232', 'leukemia;B cell lymphoma;lymphoma\r\r', 'ISH', '', 'Oncogene', '', '', '', '', '', 'Using long distance inverse-polymerase chain reaction, we mapped and sequenced six breakpoints of a complex BCL6 rearrangement t(3;13)(q27;q31)t(12;13)(p11;q31) in DLBCL cells, which places miR-17~92 antisense within the resulting ITPR2-BCL6 chimeric fusion gene rearrangement.     ///    \"MIR17HG and ITPR2-BCL6 were, despite their close configuration, independently expressed, discounting antisense regulation. \"'), ('10160', 'RARA_PLZF', 't(5;17)  / t(15;17)(q23;q12) / t(11;17)(q23;q12) / t(5;17)(q32;q12) / del(5q) / del(8q)  / t(11;17) / ', 'RARA', 'PLZF', '8605120', '230', 'acute promyelocytic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', '', '', 'A few cases of APL with a t(11;17)(q23;q12) and a PLZF/RARA fusion gene have recently been reported. '), ('10161', 'RUNX1_C11orf41', 't(11;21)(p14;q22) / ', 'RUNX1', 'C11orf41', '23102734', '225', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'A novel RUNX1-C11orf41 fusion gene in a case of acute myeloid leukemia with a t(11;21)(p14;q22)..     ///    \"Using 3\'-rapid amplification of cDNA ends and reverse transcription-polymerase chain reaction analyses, we found that RUNX1 was fused to C11orf41 on 11p14 and detected two in-frame C11orf41-RUNX1 fusion transcripts. \"    ///    A reciprocal C11orf41-RUNX1 fusion was not detected. '), ('10162', 'MLL_EPS15', 't(1;11)(p32;q23) / t(1;11)  / ', 'MLL', 'EPS15', '16826222', '221', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', 'KB', 'Seq', 'Taken together, these results suggest that TZ-1 is a new monocytic leukemia cell line with t(1;11) translocation and fusion gene MLL-EPS15.     ///    Establishment of a new human acute monocytic leukemia cell line TZ-1 with t(1;11)(p32;q23) and fusion gene MLL-EPS15..     ///    Fluorescence in situ hybridization and reverse transcription-polymerase chain reaction analyses revealed MLL-EPS15 fusion transcript and protein. '), ('10163', 'PDGFRA_FIP1L1', 'del(4)(q12q12) / ', 'PDGFRA', 'FIP1L1', '17591942', '214', 'leukemia;hypereosinophilic syndrome\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Fluorescence in situ hybridization and reverse transcriptase-polymerase chain reaction protocols were developed for an accurate del(4)(q12q12) and FIP1L1-PDGFRA fusion gene detection.     ///    \"Recently, a new acquired mutation was described in approximately 50% of the HES/CEL patients: a cryptic deletion on chromosome band 4q12 generating a FIP1L1-PDGFRA fusion gene. \"    ///    \"As targeted therapy with tyrosine kinase inhibitors has dramatically changed the prognosis of FIP1L1-PDGFRA (+) CEL, false-negative results could hamper accurate diagnosis and treatment.. \"'), ('10164', 'PAX7_FKHR', 't(1;13)(p36;q14) / t(1;13)  / ', 'PAX7', 'FKHR', '11063797', '209', 'rhabdomyosarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', ' Alveolar rhabdomyosarcoma (ARMS) is associated with the specific chromosomal translocation (2;13)(q35;q14) or its rarer variant t(1;13)(p36;q14), which produces the fusion gene PAX7-FKHR.     ///    The availability of an ARMS cell line that harbors the t(1;13)(p36;q14) constitutes a useful tool for further understanding the role of the PAX7-FKHR fusion gene in RMS oncogenesis and may improve knowledge of the possible relation between PAX7-FKHR and MYCN amplification..     ///    \"Here we describe the human cell line RC2, derived from an ARMS, which harbors a cryptic t(1;13)(p36;q14) and concomitantly shows amplification of the PAX7-FKHR fusion gene and of the MYCN oncogene. \"    ///    \"Fluorescence in situ hybridization analysis revealed multiple copies of the PAX7-FKHR fusion gene localized exclusively on a subset of double minutes, whereas multiple copies of MYCN were identified on other double minute chromosomes. \"    ///    \"The reverse transcriptase polymerase chain reaction demonstrated the expression of PAX7-FKHR mRNA in RC2 cells, although karyotype analysis failed to demonstrate a t(1;13)(p36;q14) chromosomal translocation or a derivative 13 chromosome. \"    ///    \"So far no continuous RMS cell line carrying the t(1;13)(p36;q14) has been described, and PAX7-FKHR and MYCN amplifications have always been reported to occur separately in rhabdomyosarcoma (RMS). \"    ///    Concomitant amplification and expression of PAX7-FKHR and MYCN in a human rhabdomyosarcoma cell line carrying a cryptic t(1;13)(p36;q14).. '), ('10165', 'SYT_SSX', 'p11;q11 / ', 'SYT', 'SSX', '9846971', '209', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', ' The reciprocal translocation t(X;18)(p11;q11) is known to be highly characteristic of synovial sarcoma, and its consequence, an SYT-SSX fusion gene, is expected to be a diagnostic molecular marker.     ///    \"In this study, we conducted a reverse transcription-polymerase chain reaction-based assay to detect the SYT-SSX fusion gene transcripts using archival formalin-fixed, paraffin-embedded tumor specimens from a series of 32 synovial sarcoma cases including 6 tumors found in unusual anatomical sites. \"    ///    Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues..     ///    The SYT-SSX fusion transcripts could be detected in 30 of 32 paraffin-embedded specimens (94%). '), ('10166', 'PAX3_FOXO1', 't(2;13) / t(1;3) / ', 'PAX3', 'FOXO1', '25659124', '207', '', 'ISH', '', 'Oncogene', 'Tumor_suppressor', '', 'Transcription_Factor', 'KB', 'Seq', 'The reciprocal t(2;13)(q36.1;q14.1) in human alveolar rhabdomyosarcoma (A-RMS) creates a pathognomonic PAX3-FOXO1 fusion gene.     ///    \"Indeed, more fusion genes were generated in fore limb myoblasts via a reciprocal t(1;3), which expressed correctly spliced Pax3-Foxo1 mRNA encoding Pax3-Foxo1 fusion protein. \"    ///    \"Given that the Pax3-Foxo1 fusion gene will contain all the regulatory sequences necessary for precise regulation of its expression, we propose that CRISPR-Cas9 provides a novel means to faithfully model human diseases caused by chromosome translocation in mice. \"    ///    We tested if spatial proximity of the Pax3 and Foxo1 loci in myoblasts of mice homozygous for the inversion facilitated Pax3-Foxo1 fusion gene formation upon induction of targeted CRISPR-Cas9 nuclease-induced DNA double strand breaks in Pax3 and Foxo1.     ///    \"In vivo mimicking of this translocation in mice is complicated by the fact that Pax3 and Foxo1 are in opposite orientation on their respective chromosomes, precluding formation of a functional Pax3-Foxo1 fusion via a simple translocation.\"    ///    \"In vivo mimicking of this translocation in mice is complicated by the fact that Pax3 and Foxo1 are in opposite orientation on their respective chromosomes, precluding formation of a functional Pax3-Foxo1 fusion via a simple translocation. \"    ///    Modeling of the human alveolar rhabdomyosarcoma Pax3-Foxo1 chromosome translocation in mouse myoblasts using CRISPR-Cas9 nuclease..     ///    Fluorescent in situ hybridization indicated that fore limb myoblasts show a higher frequency of Pax3/Foxo1 co-localization than hind limb myoblasts.    ///    Fluorescent in situ hybridization indicated that fore limb myoblasts show a higher frequency of Pax3/Foxo1 co-localization than hind limb myoblasts. '), ('10167', 'BCR_ABL1', 't(9;22)  / t(9;22)(q34;q11) / ', 'BCR', 'ABL1', '2171702', '201', 'chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'The association of 5\' BCR and 3\' ABL at the 5\' junction of the chromosome 9 insert was typical of that found for the BCR-ABL fusion gene in other patients with the standard t(9;22) and CML. '), ('10168', 'ETO_AML1', 't(8;21)  / t(8;21) (q22;q22) / t(1;21;8)(q25;q22;q22) / t(8;11;21)(q22;q13;q22) / t(8;21) / ', 'ETO', 'AML1', '16393685', '199', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', '', '', ' Acute myeloid leukemia (AML) with the t(8;21) (q22;q22) creating the AML1-ETO fusion gene is a distinct type of AML generally associated with a favorable prognosis.     ///    Fluorescence in situ hybridization or reverse transcriptase-polymerase chain reaction assay confirmed the presence of AML1-ETO or its transcripts in 3 cases assessed. '), ('10169', 'ETO_AML1', 't(8;21)  / t(8;21) / ', 'ETO', 'AML1', '16203765', '199', 'mast cell disease;mastocytosis', '', '', '', '', '', '', '', '', 'As assessed by in situ fluorescence hybridization combined with tryptase staining, both the tryptase-negative blast cells and the tryptase-positive mast cells were found to contain the t(8;21)-specific AML1/ETO fusion gene.     ///    \"Myeloablative stem cell transplantation resulted in complete remission with consecutive disappearance of AML1/ETO transcripts, decrease of serum tryptase to normal range, and disappearance of neoplastic mast cells. \"'), ('10170', 'JJAZ1_JAZF1', 't(7;17) / t(7;17)  / ', 'JJAZ1', 'JAZF1', '15043312', '189', 'endometrial stromal sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Using a nonnested reverse transcriptase-polymerase chain reaction approach, we assayed for JAZF1-JJAZ1 gene fusion transcripts in 10 cases with available fresh-frozen tissue.     ///    \"JAZF1-JJAZ1 gene fusion transcripts were detected in five (33%) of 15 ESTs, including three of eight primary uterine, one of four metastatic, one of one extrauterine, and none of two recurrent cases. \"    ///    \"JAZF1-JJAZ1 gene fusion transcripts were detected in five (33%) of 15 ESTs, including three of eight primary uterine, one of four metastatic, one of one extrauterine, and none of two recurrent cases.\"    ///    \"The aim of this study was to evaluate the frequency of the JAZF1-JJAZ1 gene fusion among primary uterine, metastatic, and primary extrauterine ESTs of various histologic types and its role as a possible diagnostic adjunct. \"    ///    Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity..     ///    \"The aim of this study was to evaluate the frequency of the JAZF1-JJAZ1 gene fusion among primary uterine, metastatic, and primary extrauterine ESTs of various histologic types and its role as a possible diagnostic adjunct.\"    ///    \"Hence, the diagnostic utility of a JAZF1-JJAZ1 fusion transcript assay in ESTs may be limited to the classic histologic subset.. \"    ///    Positivity for JAZF1-JJAZ1 fusion transcripts was found in four of 10 fresh-frozen samples and in one of five paraffin-embedded ESTs.     ///    \"Most ESTs of classic histology showed evidence of JAZF1-JJAZ1 fusion (4 of 5 cases), whereas only one mixed smooth muscle ESN of 10 variant cases was positive. \"    ///    \"In conclusion, our data suggest that ESTs are genetically heterogeneous, with the prevalence of the JAZF1-JJAZ1 fusion being highest among ESTs of classic histology. \"'), ('10171', 'EWSR1_CREB3L1', 'p11.2;q12.2 / 11p11.2 / ', 'EWSR1', 'CREB3L1', '25123073', '188', 'fibrosarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', 'Sclerosing epithelioid fibrosarcoma presenting as intraabdominal sarcomatosis with a novel EWSR1-CREB3L1 gene fusion..     ///     We report a case of intraabdominal sclerosing epithelioid fibrosarcoma (SEF) with a t (11;22)(p11.2;q12.2) Ewing sarcoma breakpoint region 1-cAMP-responsive element-binding protein 3-like 1 translocation.     ///    \"This is the first report of \"\"pure\"\" or true SEF presenting as intraabdominal sarcomatosis with confirmation of the recently described unique Ewing sarcoma breakpoint region 1-cAMP-responsive element-binding protein 3-like 1 gene fusion in SEF without areas of low-grade fibromyxoid sarcoma. \"'), ('10172', 'HLF_E2A', 't(17;19)  / t(17;19)(q22;p13) / ', 'HLF', 'E2A', '16531271', '184', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', '', '', '', '', ' This is the first report to comprehensively characterize the E2A-HLF fusion generated from the t(17;19)(q22;p13) translocation in childhood B-lineage acute lymphoblastic leukemia.     ///    Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients\' cells..     ///    \"E2A gene rearrangement and E2A-HLF transcript and protein expression were determined using conventional cytogenetics, fluorescent in situ hybridization, reverse transcriptase polymerase chain reaction and Western blotting in leukemic cells from three patients.. \"'), ('10173', 'ETO_AML1', 't(8;21)  / ', 'ETO', 'AML1', '15634569', '179', '', 'ISH', '', '', '', '', '', '', '', 'Tumor cells xenografted could not be found in other tissues than in inoculation area, and still harbored the specific t(8;21) and AML1-ETO fusion gene. '), ('10174', 'NUP98_HOXD13', 't(2;11)(q31;p15) / ', 'NUP98', 'HOXD13', '9766650', '176', 'leukemia\r\r', 'ISH', '', 'Oncogene', '', '', '', 'KB', 'Seq', 'NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia..     ///    \"The NUP98-HOXD13 fusion is structurally similar to the NUP98-HOXA9 fusion previously identified in patients with AML, leading to the speculation that NUP98-homeobox gene fusions may be oncogenic. \"'), ('10175', 'HOX_NUP98', 't(2;11)(q31;p15) / ', 'HOX', 'NUP98', '9766650', '176', 'leukemia\r\r', 'ISH', '', '', '', '', '', '', '', 'The NUP98-HOXD13 fusion is structurally similar to the NUP98-HOXA9 fusion previously identified in patients with AML, leading to the speculation that NUP98-homeobox gene fusions may be oncogenic. '), ('10176', 'PAX3_FKHR', '', 'PAX3', 'FKHR', '18705836', '171', 'rhabdomyosarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Adult cutaneous alveolar rhabdomyosarcoma on the face diagnosed by the expression of PAX3-FKHR gene fusion transcripts..     ///    The diagnosis of alveolar rhabdomyosarcoma was confirmed by the detection of PAX3-FKHR fusion gene transcripts in the paraffin-embedded tumor tissue.     ///    \"This adult case of an alveolar rhabdomyosarcoma primarily occurring on the face is very rare, and the detection of PAX3-FKHR fusion gene transcripts was useful for diagnosis of the disease.. \"'), ('10177', 'FLI1_EWSR1', 't(11;22) / t(21;22) / t(2;22)  / ', 'FLI1', 'EWSR1', '21458383', '165', '', '', '', '', '', '', '', '', 'Seq', 'We found five distinct types of EWSR1-FLI1 fusion transcripts resulting from translocation t(11;22), three types of EWSR1-ERG transcripts resulting from t(21;22), and one type of t(2;22) resulting in EWSR1-FEV fusion. '), ('10178', 'TMPRSS2_ERG', '', 'TMPRSS2', 'ERG', '20562851', '164', 'prostate cancer\r\r', 'ISH', '', '', '', '', '', 'KB', 'Seq', 'TMPRSS2-ERG gene fusion is associated with low Gleason scores and not with high-grade morphological features..     ///    TMPRSS2-ERG gene fusion is associated with lower core-specific and overall Gleason scores and not with high-grade morphologies.     ///    \" TMPRSS2-ERG gene rearrangement is seen in about half of clinically localized prostate cancers, yet controversy exists with regard to its prognostic implications. \"    ///    \"Using maximum Gleason score, based on three core evaluation, and overall Gleason score, based on prostatectomy sections, Fisher\'s exact test was performed for tumors with TMPRSS2-ERG translocation/deletion, copy number increase (? 3) of the TMPRSS2-ERG region without translocation/deletion, and copy number increase and concomitant translocation/deletion. \"    ///    These findings indicate that translocation/deletion of TMPRSS2-ERG is not associated with histological features of aggressive prostate cancer..     ///    \"Conversely, TMPRSS2-ERG copy number increase, with or without rearrangement, is associated with higher Gleason score. \"    ///    \"No significant difference in TMPRSS2-ERG incidence was observed between patients with and without cribriform glands, glomerulations, signet-ring cells, or intraductal cancer (P=0.821, 0.095, 0.132, 0.375). \"    ///    Fluorescence in situ hybridization was performed to delineate TMPRSS2-ERG aberrations. '), ('10179', 'PDGFB_COL1A1', 't(17;22) / ', 'PDGFB', 'COL1A1', '16080955', '162', 'dermatofibrosarcoma protuberans;sarcoma\r\r', 'ISH', '', 'Oncogene', '', '', '', 'KB', '', 'Subsequent reverse-transcription polymerase chain reaction revealed that the cell line did not have the COL1A1-PDGFB gene fusion. '), ('10180', 'NTRK3_ETV6', '', 'NTRK3', 'ETV6', '23773480', '159', 'acinic cell carcinoma', 'ISH', 'Kinase', '', '', '', '', 'KB', 'Seq', ' Mammary analogue secretory carcinoma is a recently described salivary gland neoplasm defined by ETV6-NTRK3 gene fusion.     ///    Utility of mammaglobin immunohistochemistry as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma.. '), ('10181', 'SEPT5_MLL', 't(11;22)(q23;q11) / ', 'SEPT5', 'MLL', '23725386', '158', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', 'KB', '', 'MLL-SEPT5 fusion transcript in infant acute myeloid leukemia with t(11;22)(q23;q11)..     ///    \"Clinical, cytogenetic and molecular features of acute myeloid leukemia with a MLL-SEPT5 fusion gene are reviewed.. \"    ///    Long distance inverse-polymerase chain reaction was used to identify precisely the MLL partner gene and confirmed the MLL-SEPT5 fusion transcript. '), ('10182', 'FUS_ERG', 't(16;21) / p11.2;q22 / ', 'FUS', 'ERG', '26770812', '157', 'myeloid leukemia', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', 'FUS-ERG gene fusion in isolated myeloid sarcoma showing uncommon clinical features..     ///    \"To our knowledge, this is the first report of isolated MS carrying FUS-ERG gene fusion. \"    ///    \" FUS-ERG gene fusion has not been reported in cases of myeloid sarcoma (MS), a subtype of acute myeloid leukemia involving extramedullary anatomic sites. \"    ///    Reverse transcriptase polymerase chain reaction and direct sequencing demonstrated the presence of the FUS-ERG chimeric gene transcript. '), ('10183', 'NTRK3_ETV6', '', 'NTRK3', 'ETV6', '26367451', '156', 'thyroid nodule;thyroid carcinoma\r\r', '', 'Kinase', '', '', '', '', 'KB', 'Seq', 'These gene fusions included ETV6/NTRK3 (n=3) and TPR/NTRK1 (n=1).     ///    \"Some cases with chromosomal rearrangements, including ETV6/NTRK3, appear to be associated with an aggressive histopathologic phenotype, but had no documented history of radiation exposure. \"'), ('10184', 'EWSR1_ATF1', 't(12;22)(q13;q12) / ', 'EWSR1', 'ATF1', '18300804', '155', 'clear cell sarcoma;malignant meningioma;microphthalmia', '', '', '', '', '', 'Transcription_Factor', 'KB', 'Seq', ' Clear cell sarcoma (CCS) of soft tissue is a rare sarcoma with morphologic similarities to malignant melanoma but a distinct genetic background including a chromosomal translocation, t(12;22)(q13;q12), or a resultant EWSR1-ATF1 fusion gene.     ///    \"Reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues demonstrated transcripts of the EWSR1-ATF1 (31/33) or EWSR1-CREB1 fusion gene (2/33). \"    ///    \"Reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues demonstrated transcripts of the EWSR1-ATF1 (31/33) or EWSR1-CREB1 fusion gene (2/33).\"    ///    \"In cases with unusual histologic findings, molecular detection of the EWSR1-ATF1/CREB1 fusion genes provides critical information regarding the diagnosis of the tumor.. \"'), ('10185', 'EML4_ALK', '', 'EML4', 'ALK', '23408463', '154', 'lung cancer;adenocarcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'All informative pairs were concordant either for the norm (32 of 36 pairs) or for the presence of EML4-ALK gene fusion (4 of 36 pairs).     ///    RNA extraction followed by reverse transcriptase-polymerase chain reaction analysis for the EML4-ALK translocation was performed for 44 EGFR mutation-negative sample pairs.     ///    Detection of EGFR mutations and EML4-ALK rearrangements in lung adenocarcinomas using archived cytological slides.. '), ('10186', 'MECT1_MAML2', '', 'MECT1', 'MAML2', '17539914', '154', 'small cell carcinoma;pleomorphic adenoma;B cell lymphoma;adenocarcinoma;mucoepidermoid carcinoma;lymphoma\r\r', '', '', '', '', '', '', '', '', 'Specific chromosomal translocations are recognized in pleomorphic adenoma (with translocation involving PLGA1 or HMGA2 gene) and mucoepidermoid carcinoma (with MECT1-MAML2 gene fusion). '), ('10187', 'WNK1_B4GALNT3', '', 'WNK1', 'B4GALNT3', '25803323', '151', '', '', 'Kinase', '', '', '', '', '', 'Seq', 'New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma.. '), ('10188', 'PAX7_FKHR', '', 'PAX7', 'FKHR', '16645206', '149', 'rhabdomyosarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', ' Alveolar rhabdomyosarcoma (ARMS) is a soft tissue cancer in which chromosomal translocations generate PAX3-FKHR and PAX7-FKHR gene fusions.     ///    \"The distribution of fusion types was 35 (59%) PAX3-FKHR, 11 (19%) PAX7-FKHR, and 13 fusion-negative (22%). \"'), ('10189', 'PAX3_FKHR', '', 'PAX3', 'FKHR', '16645206', '149', 'rhabdomyosarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', ' Alveolar rhabdomyosarcoma (ARMS) is a soft tissue cancer in which chromosomal translocations generate PAX3-FKHR and PAX7-FKHR gene fusions.     ///    \"The distribution of fusion types was 35 (59%) PAX3-FKHR, 11 (19%) PAX7-FKHR, and 13 fusion-negative (22%). \"'), ('10190', 'TMPRSS2_ERG', '', 'TMPRSS2', 'ERG', '22240201', '149', 'prostate cancer\r\r', '', '', '', '', '', '', 'KB', 'Seq', 'These include the seminal discovery of chromosomal translocations such as TMPRSS2-ERG gene fusions as well as the identification of critical oncogenes exemplified by the polycomb group protein EZH2. '), ('10191', 'PAX3_FKHR', '', 'PAX3', 'FKHR', '9098647', '149', 'rhabdomyosarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'The PAX3-FKHR and PAX7-FKHR gene fusions that result from chromosomal translocations in this tumor provide potential molecular diagnostic markers.     ///    \"To apply these molecular markers to commonly available archival material, we used reverse transcriptase-polymerase chain reaction and oligonucleotide hybridization methodology to develop an assay capable of identifying PAX3-FKHR and PAX7-FKHR fusion transcripts in formalin-fixed, paraffin-embedded tissue. \"    ///    Comparison of assay results for the PAX3-FKHR and PAX7-FKHR fusions with standard molecular assays of paired frozen material revealed that all eight cases of known fusion-positive rhabdomyosarcoma were correctly identified and distinguished as PAX3-FKHR or PAX7-FKHR. '), ('10192', 'PAX7_FKHR', '', 'PAX7', 'FKHR', '9098647', '149', 'rhabdomyosarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'The PAX3-FKHR and PAX7-FKHR gene fusions that result from chromosomal translocations in this tumor provide potential molecular diagnostic markers.     ///    \"To apply these molecular markers to commonly available archival material, we used reverse transcriptase-polymerase chain reaction and oligonucleotide hybridization methodology to develop an assay capable of identifying PAX3-FKHR and PAX7-FKHR fusion transcripts in formalin-fixed, paraffin-embedded tissue. \"    ///    Comparison of assay results for the PAX3-FKHR and PAX7-FKHR fusions with standard molecular assays of paired frozen material revealed that all eight cases of known fusion-positive rhabdomyosarcoma were correctly identified and distinguished as PAX3-FKHR or PAX7-FKHR. '), ('10193', 'TTC23_IGF1R', '1p36.22 / ', 'TTC23', 'IGF1R', '26898937', '148', 'bladder cancer\r\r', '', 'Kinase', '', '', '', '', '', '', 'Chromosomal rearrangements of regions 17q25, 15q26.3 and 1p36.22 resulting in the fusion transcripts SEPT9/CYHR, IGF1R/TTC23 and CASZ1/DFFA, appeared to be rare or unique events because they were not detected in the 48 UC samples.     ///    \"Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer. \"'), ('10194', 'NUP98_HOXD13', 't(2;11;9)(q31;p15;q22) / t(6;11;15)(q21;q23;q22) / t(8;10)(q13;q22) / ', 'NUP98', 'HOXD13', '17656257', '147', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', '', '', 'KB', 'Seq', 'The NUP98-HOXD13 fusion transcript created by t(2;11;9)(q31;p15;q22) may play an important role in the leukemogenesis in this case..     ///    Fluorescence in situ hybridization and a reverse transcription-polymerase chain reaction assay detected the NUP98-HOXD13 fusion gene in bone marrow cells of the patient at diagnosis and at relapse.     ///    \"A complex karyotype, including a three-way translocation generating a NUP98-HOXD13 transcript, in an infant with acute myeloid leukemia.. \"'), ('10195', 'NTRK3_ETV6', '', 'NTRK3', 'ETV6', '23042752', '147', 'pleomorphic adenoma;acinic cell carcinoma;mucoepidermoid carcinoma;salivary gland cancer\r\r', 'ISH', 'Kinase', '', '', '', '', 'KB', 'Seq', ' Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland neoplasm that is defined by ETV6-NTRK3 gene fusion. '), ('10196', 'ZMIZ1_PRR12', 't(10;19) / t(10;19)  / ', 'ZMIZ1', 'PRR12', '26163108', '146', '', '', '', '', '', '', '', '', '', 'A de novo t(10;19)(q22.3;q13.33) leads to ZMIZ1/PRR12 reciprocal fusion transcripts in a girl with intellectual disability and neuropsychiatric alterations.. '), ('10197', 'PDGFB_COL1A1', '', 'PDGFB', 'COL1A1', '12131162', '144', 'dermatofibrosarcoma protuberans;sarcoma\r\r', '', '', 'Oncogene', '', '', '', 'KB', '', 'COL1A1-PDGFB gene fusion demonstrates a common histogenetic origin for dermatofibrosarcoma protuberans and its granular cell variant..     ///    We report a new case in which we demonstrated the presence of the dermatofibrosarcoma protuberans-specific COL1A1-PDGFB fusion from paraffin-embedded tissue. '), ('10198', 'NTRK3_ETV6', '', 'NTRK3', 'ETV6', '14691916', '144', 'ductal carcinoma', 'ISH', 'Kinase', '', '', '', '', 'KB', 'Seq', 'On this basis, we evaluated 13 SCAs (12 of them with ETV6-NTRK3 gene fusion) by molecular and immunohistochemical (IHC) methods. '), ('10199', 'RET_KIF5B', '', 'RET', 'KIF5B', '22327622', '144', 'non small cell lung cancer;colorectal cancer;lung cancer;adenocarcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Further screening of 561 lung adenocarcinomas identified 11 additional tumors with KIF5B-RET gene fusions (2.0%.     ///    \" Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma. \"    ///    Cells expressing oncogenic KIF5B-RET are sensitive to multi-kinase inhibitors that inhibit RET.. '), ('10200', 'KIAA1549_BRAF', '', 'KIAA1549', 'BRAF', '24422672', '144', 'sarcoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Genomic profiling identified the following alterations: a KIAA1549-BRAF gene fusion resulting from a tandem duplication event, a homozygous deletion of PTEN, and frameshift insertion/deletions in CDKN2A A68fs*51, SUFU E283fs*3, and MAP3K1 N325fs*3.     ///    \"The patient responded to combination targeted therapy that fortuitously targeted KIAA1549-BRAF and PTEN loss within a spindle cell neoplasm, as revealed by genomic profiling based on NGS. \"    ///    This is the first report of a tumor driven by a KIAA1549-BRAF fusion responding to sorafenib-based combination therapy..     ///    Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein.. '), ('10201', 'KIAA1549_BRAF', '', 'KIAA1549', 'BRAF', '22814862', '144', 'pilocytic astrocytoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'However, we found no cases showing KIAA1549-BRAF gene fusion or BRAF                         (V600E) mutation.     ///    Absence of KIAA1549-BRAF fusion in rosette-forming glioneuronal tumors of the fourth ventricle (RGNT).    ///    Absence of KIAA1549-BRAF fusion in rosette-forming glioneuronal tumors of the fourth ventricle (RGNT)..     ///    \"To evaluate potential similarities at the molecular level between these tumors, we analysed a series of 10 RGNT for the presence of KIAA1549-BRAF fusions using interphase fluorescence in situ hybridisation. \"'), ('10202', 'TRKA_LMNA', '', 'TRKA', 'LMNA', '26216294', '144', 'soft tissue neoplasm;soft tissue sarcoma', '', '', '', '', '', '', '', '', 'The tumor of a 41-year-old woman with soft-tissue sarcoma metastatic to the lung was found to harbor an LMNA-NTRK1 gene fusion encoding a functional LMNA-TRKA fusion oncoprotein as determined by an in situ proximity ligation assay.     ///    \"A patient with a metastatic soft-tissue sarcoma with an LMNA-NTRK1 fusion had rapid and substantial tumor regression with a novel, highly selective TRK inhibitor, LOXO-101, providing the first clinical evidence of benefit from inhibiting TRK fusions..\"    ///    \"A patient with a metastatic soft-tissue sarcoma with an LMNA-NTRK1 fusion had rapid and substantial tumor regression with a novel, highly selective TRK inhibitor, LOXO-101, providing the first clinical evidence of benefit from inhibiting TRK fusions.. \"'), ('10203', 'C2orf44_ALK', '', 'C2orf44', 'ALK', '22327622', '144', 'non small cell lung cancer;colorectal cancer;lung cancer;adenocarcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', '', ' Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma.     ///    \"Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma.\"'), ('10204', 'TMPRSS2_ERG', '', 'TMPRSS2', 'ERG', '25925381', '144', 'prostate cancer\r\r', '', '', '', '', '', '', 'KB', 'Seq', 'We validated OCP using molecular standards and more than 300 FFPE tumor samples, achieving >95% accuracy for KRAS, epidermal growth factor receptor, and BRAF mutation detection as well as for ALK and TMPRSS2:ERG gene fusions. '), ('10205', 'NTRK3_ETV6', '', 'NTRK3', 'ETV6', '11381370', '144', 'nephroma\r\r', 'ISH', 'Kinase', '', '', '', '', 'KB', 'Seq', 'RNA extraction was performed on formalin-fixed, paraffin-embedded tissue from 7 mixed epithelial and stromal tumors followed by reverse-transcription polymerase chain reaction to detect the ETV6-NTRK3 gene fusion. '), ('10206', 'JJAZ1_JAZF1', '', 'JJAZ1', 'JAZF1', '16049311', '143', 'endometrial stromal sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'In combination with other established methods, accurate reverse transcriptase-polymerase chain reaction analysis of JAZF1/JJAZ1 gene fusion may be useful in diagnosing difficult or unusual ESS/UES cases..     ///    JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue..     ///    \"In comparison to published data, our results identified the JAZF1/JJAZ1 gene fusion more frequently in endometrial stromal tumors than hitherto presumed. \"    ///    \"In our subset of samples, the JAZF1/JJAZ1 fusion transcript occurred in 80% of analyzed ESS cases and in none of two UES cases. \"    ///    \"Hitherto only 31 cases, described by three different research groups, have shown JAZF1/JJAZ1 fusion in approximately 50% of all analyzed low-grade ESSs whereas it is less frequent in UESs. \"'), ('10207', 'FUS_CREB3L2', '', 'FUS', 'CREB3L2', '25437654', '143', 'sarcoma\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', 'Reverse transcription polymerase chain reaction from a formalin-fixed, paraffin-embedded biopsy specimen revealed a FUS-CREB3L2 gene fusion (exon6/int/exon5), leading to the diagnosis of LGFMS.     ///    A case of low-grade fibromyxoid sarcoma with unusual central necrosis in a 77-year-old man confirmed by FUS-CREB3L2 gene fusion.. '), ('10208', 'DUX4_CIC', 't(4;19) / ', 'DUX4', 'CIC', '21813156', '142', 'sarcoma\r\r', '', '', '', '', '', '', '', '', 'Recent studies have identified a subgroup of undifferentiated soft tissue sarcomas with primitive round to plump spindle cell morphology and a t(4;19)(q35;q13.1) translocation resulting in the expression of a CIC-DUX4 fusion transcript, including 2 tumors previously reported by our laboratory (Cancer Genet Cytogenet 2009;195:1).     ///    The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomas..     ///    \"In the present study, reverse transcriptase polymerase chain reaction assays developed for both frozen and paraffin-based tissues were applied to a series of 19 pediatric undifferentiated soft tissue sarcomas using a combination of primer sets covering the CIC-DUX4 fusion transcript. \"    ///    Three of the 16 undifferentiated soft tissue sarcomas with primitive round cell morphology were found to harbor the CIC-DUX4 fusion transcript by reverse transcriptase polymerase chain reaction.     ///    \"Given the consistent involvement of the CIC-DUX4 fusion in a subset of primitive round cell undifferentiated soft tissue sarcomas, these findings suggest a central role for the fusion transcript in such tumors. \"'), ('10209', 'SYT_SSX', 'p11.2;q11.2 / ', 'SYT', 'SSX', '18720326', '142', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'They are often characterized by the chromosomal translocation t(X;18)(p11.2;q11.2), which results in the expression of SYT-SSX fusion transcripts.     ///    First case report of a fetal synovial sarcoma confirmed by molecular detection of SYT-SSX fusion gene transcripts.. '), ('10210', 'RUNX1T1_RUNX1', 't(8;21)(q22;q22) / ', 'RUNX1T1', 'RUNX1', '19896694', '142', 'acute myeloid leukemia;myeloid leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', ' t(8;21)(q22;q22) giving rise to RUNX1/RUNX1T1 fusion transcript is a recurrent non-random chromosomal translocation, accounting for approximately 5% of cases of acute myeloid leukemia and 10% of acute myeloid leukemia with maturation.     ///    \"Interphase and metaphase fluorescent in situ hybridization have revealed a RUNX1/RUNX1T1 fusion signal on derivative chromosome 8 but not on chromosome 21, confirming the unbalanced translocation between chromosomes 8q22 and 21q22 involving both the RUNX1 and RUNX1T1 genes. \"'), ('10211', 'TYK2_NPM1', '', 'TYK2', 'NPM1', '25349176', '142', 'anaplastic large cell lymphoma,;lymphoproliferative disorder', 'ISH', 'Kinase', '', '', '', 'Transcription_Factor', '', '', 'A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders..     ///    \"Functionally, NPM1-TYK2 induced constitutive TYK2, signal transducer and activator of transcription 1 (STAT1), STAT3, and STAT5 activation. \"    ///    \"Conversely, a kinase-defective NPM1-TYK2 mutant abrogated STAT1/3/5 signaling. \"    ///    Fluorescence in situ hybridization revealed NPM1-TYK2 fusions in 2 of 47 (4%) primary cases of CD30-positive LPDs and was absent in other mature T-cell neoplasms (n = 151).     ///    \"Using whole-transcriptome sequencing, we identified a chimeric fusion involving NPM1 (5q35) and TYK2 (19p13) that encodes an NPM1-TYK2 protein containing the oligomerization domain of NPM1 and an intact catalytic domain in TYK2. \"'), ('10212', 'EWSR1_ERG', 't(11;22) / t(21;22) / t(2;22)  / ', 'EWSR1', 'ERG', '21458383', '140', '', '', '', '', '', '', '', 'KB', 'Seq', 'We found five distinct types of EWSR1-FLI1 fusion transcripts resulting from translocation t(11;22), three types of EWSR1-ERG transcripts resulting from t(21;22), and one type of t(2;22) resulting in EWSR1-FEV fusion.     ///    \"We found five distinct types of EWSR1-FLI1 fusion transcripts resulting from translocation t(11;22), three types of EWSR1-ERG transcripts resulting from t(21;22), and one type of t(2;22) resulting in EWSR1-FEV fusion.\"'), ('10213', 'FEV_EWSR1', 't(11;22) / t(21;22) / t(2;22)  / ', 'FEV', 'EWSR1', '21458383', '140', '', '', '', '', '', '', '', 'KB', '', 'We found five distinct types of EWSR1-FLI1 fusion transcripts resulting from translocation t(11;22), three types of EWSR1-ERG transcripts resulting from t(21;22), and one type of t(2;22) resulting in EWSR1-FEV fusion. '), ('10214', 'NAB2_STAT6', '', 'NAB2', 'STAT6', '26337721', '139', 'solitary fibrous tumor\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', 'We have reported a case of GRIA2 and PAX8-positive SFT occurring primarily in the kidney with such NAB2-STAT6 gene fusion for the first time.    ///    We have reported a case of GRIA2 and PAX8-positive SFT occurring primarily in the kidney with such NAB2-STAT6 gene fusion for the first time.     ///    A GRIA2 and PAX8-positive renal solitary fibrous tumor with NAB2-STAT6 gene fusion.. '), ('10215', 'MYC_C15orf21', '', 'MYC', 'C15orf21', '22294438', '139', 'prostate cancer;adenocarcinoma\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Remarkably, the repertoire of expressed but apparently private gene fusions, including C15orf21:MYC, recapitulated this biology. '), ('10216', 'TMPRSS2_ERG', '', 'TMPRSS2', 'ERG', '23664537', '138', 'adenocarcinoma\r\r', 'ISH', '', '', '', '', '', 'KB', 'Seq', 'Immunohistochemical evaluation of TMPRSS2-ERG gene fusion in adenosis of the prostate.. '), ('10217', 'ETO_AML1', 't(8;21) / t(15;17) / ', 'ETO', 'AML1', '26299742', '137', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', '', '', '', '', '', '', '', '', 'Moreover, we found a favorable clinical outcome in patients expressing fusion genes AML1-ETO or PMLRARA in contrast to an adverse clinical outcome with few remissions and death in AML patients with MLL, -5q/?-5 and -7q/?7-. '), ('10218', 'EWSR1_CREB1', 't(12;22)(q13;q12) / ', 'EWSR1', 'CREB1', '22406360', '136', 'clear cell sarcoma;melanoma;sarcoma\r\r', 'ISH', '', '', '', '', 'Transcription_Factor', 'KB', '', 'The presence of type 1, 2, and 3 EWSR1/ATF1 fusion gene transcripts was confirmed by reverse transcriptase polymerase chain reaction analysis, but type 4 and EWSR1/CREB1 fusion gene transcripts were not found. '), ('10219', 'EWSR1_ATF1', 't(12;22)(q13;q12) / ', 'EWSR1', 'ATF1', '22406360', '136', 'clear cell sarcoma;melanoma;sarcoma\r\r', 'ISH', '', '', '', '', 'Transcription_Factor', 'KB', 'Seq', 'The presence of type 1, 2, and 3 EWSR1/ATF1 fusion gene transcripts was confirmed by reverse transcriptase polymerase chain reaction analysis, but type 4 and EWSR1/CREB1 fusion gene transcripts were not found. '), ('10220', 'CBP_MYST3', 't(8;16)(p11;p13) / ', 'CBP', 'MYST3', '17296583', '135', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', '', '', '', '', '', '', '', '', 'New types of MYST3-CBP and CBP-MYST3 fusion transcripts in t(8;16)(p11;p13) acute myeloid leukemias.     ///    New types of MYST3-CBP and CBP-MYST3 fusion transcripts in t(8;16)(p11;p13) acute myeloid leukemias..     ///    Two types of MYST3-CBP and CBP-MYST3 fusion transcripts have been identified in patients.     ///    We describe two new types of MYST3-CBP transcripts and a new primer set.. '), ('10221', 'MLL_ELL', 't(11;19) / 19p13.1 / ', 'MLL', 'ELL', '18617060', '135', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', 'KB', 'Seq', 'A novel variant form of MLL-ELL fusion transcript with t(11;19)(q23;p13.1) in chronic myelomonocytic leukemia transforming to acute myeloid leukemia..     ///    \"Thus, a possibility is raised that the unique clinical presentation of the present case with t(11;19)(q23;p13.1) might be related to the variant form of MLL-ELL.. \"    ///    \"It is deduced that the variant form of MLL-ELL may be defective not only in inhibition of transcription initiation, but also in transcriptional elongation. \"    ///    Sequence analysis of reverse-transcriptional polymerase chain reaction product revealed a novel variant form of MLL-ELL transcript in which MLL exon 10 was fused to ELL exon 3.     ///    \"MLL has been fused to ELL exon 2 in all the previously reported MLL-ELL transcripts, which have always been associated with AML. \"'), ('10222', 'LPP_HMGA2', 't(3;12)(q27;q14-15) / ', 'LPP', 'HMGA2', '18551755', '134', 'liposarcoma;sarcoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', 'Reverse-transcriptase polymerase chain reaction followed by sequencing analysis confirmed the presence of the HMGA2-LPP fusion gene, a characteristic and the most common fusion product found in lipoma.     ///    \"Reverse-transcriptase polymerase chain reaction followed by sequencing analysis confirmed the presence of the HMGA2-LPP fusion gene, a characteristic and the most common fusion product found in lipoma.\"'), ('10223', 'TEL_AML1', 't(12;21)  / ', 'TEL', 'AML1', '12699887', '134', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', '', '', 'The TEL/AML1 fusion gene was located on the derivative chromosome 21 but a segment of the long arm of a chromosome 3 was inserted between the proximal part of the short arm of the derivative chromosome 12 and the reciprocal part of the AML1 gene.     ///    Fluorescence in situ hybridization with TEL/AML1 probes and chromosome paints revealed complex rearrangements. '), ('10224', 'NFATC1_EWSR1', 't(18;22)(q23;q12) / ', 'NFATC1', 'EWSR1', '23480895', '132', 'ewing sarcoma;sarcoma\r\r', 'ISH', '', '', '', '', 'Transcription_Factor', 'KB', '', 'A benign vascular tumor with a new fusion gene: EWSR1-NFATC1 in hemangioma of the bone..     ///    \"In this study, we report the finding of a new fusion gene, EWSR1-NFATC1, in a hemangioma of the bone. \"    ///    \"Fluorescence in situ hybridization mapping suggested the involvement of each of the 2 partner genes, and reverse transcriptase polymerase chain reaction revealed an in-frame EWSR1-NFATC1 transcript. \"'), ('10225', 'FLI_EWS', 't(11;22)(q24;q12) / ', 'FLI', 'EWS', '10030577', '131', 'ewing sarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', 'Molecular analysis showed chromosomal translocation t(11;22)(q24;q12) or EWS/FLI-1 rearrangement in the malignant cells of the eye. '), ('10226', 'IG_BCL2', 't(14;18)(q32;q21) / t(14;18)  / ', 'IG', 'BCL2', '2834197', '131', '', '', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.. '), ('10227', 'RARA_PLZF', 't(11;17)(q23;q21) / t(11;17) (q23;21) / t(15;17)  / t(11;17) / ', 'RARA', 'PLZF', '8387545', '128', 'acute promyelocytic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', '', '', 'The fusion PLZF-RAR alpha gene found in this case, was not found in DNA obtained from the bone marrow of normals, APL with t(15;17) and in one patient with AML-M2 with a t(11;17). '), ('10228', 'MLL_ELL', 't(11;19) / t(8;12)(q13;p13) / t(11;19) (q23;p13) / t(11;19)(q23;p13) / t(8;12)  / t(8;12) / 19p13.1 / t(8;12)(q12;p13) / ', 'MLL', 'ELL', '12377416', '128', 'acute myeloid leukemia', 'ISH', '', '', '', '', '', 'KB', 'Seq', 'Reverse transcription-polymerase chain reaction analysis detected the MLL/ELL fusion transcript, indicating that the breakpoint on chromosome 19 was 19p13.1. '), ('10229', 'PAX7_FKHR', 't(2;13)(q35;q14) / t(1;13)(p36;q14) / ', 'PAX7', 'FKHR', '24427371', '127', 'alveolar rhabdomyosarcoma;T cell lymphoma', 'ISH', '', '', '', '', '', '', '', 'Recent studies of ARMS have shown two specific recurrent translocations: PAX3-FKHR [t(2;13)(q35;q14)] or PAX7-FKHR [t(1;13)(p36;q14)]. '), ('10230', 'PAX3_FKHR', 't(2;13)(q35;q14) / t(1;13)(p36;q14) / ', 'PAX3', 'FKHR', '24427371', '127', 'alveolar rhabdomyosarcoma;T cell lymphoma', 'ISH', '', '', '', '', '', '', '', 'Recent studies of ARMS have shown two specific recurrent translocations: PAX3-FKHR [t(2;13)(q35;q14)] or PAX7-FKHR [t(1;13)(p36;q14)]. '), ('10231', 'NPM_ALK', 't(2;5)(p23;q35) / t(2;5)  / ', 'NPM', 'ALK', '8701987', '126', 'lymphomatoid papulosis;non Hodgkin Lymphoma', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', 'To identify cells carrying the t(2;5) translocation, we used immunohistochemistry to detect the ALK-encoded p80 protein and in situ hybridization for the specific detection of NPM-ALK transcripts.     ///     The t(2;5) generates a chimeric NPM-ALK transcript encoded by the nucleophosmin NPM gene fused to the anaplastic lymphoma kinase gene ALK.     ///    Both p80 protein and NPM-ALK transcripts were expressed by anaplastic or large CD30+ lymphoma cells with positive NPM-ALK amplification.     ///    Using a reverse transcriptase nested polymerase chain reaction assay we have detected NPM-ALK transcripts within CD30+ primary cutaneous lymphoma and lymphomatoid papulosis (LP). '), ('10232', 'MALT1_API2', '', 'MALT1', 'API2', '22880230', '126', 'macroglobulinemia;MALT lymphoma', 'ISH', '', '', '', '', '', '', '', 'Chromosome translocation was analyzed by the G-banded karyotype, and API2/MALT1 fusion gene underwent fluorescent in situ hybridization. '), ('10233', 'PDGFB_COL1A1', 't(17;22)(q22;q13) / ', 'PDGFB', 'COL1A1', '19016705', '125', 'dermatofibrosarcoma protuberans;sarcoma\r\r', 'ISH', '', 'Oncogene', '', '', '', 'KB', '', 'Fluorescence in situ hybridization analysis did not reveal the DFSP fusion gene COL1A1-PDGFB. '), ('10234', 'NPM_ALK', 't(2;5)(p23;q35) / ', 'NPM', 'ALK', '11215285', '124', 'anaplastic large cell lymphoma;lymphoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Despite multiple copies of the normal ALK gene, immunohistochemical, reverse transcriptase polymerase chain reaction, and western blot analysis demonstrated that only the fusion gene NPM/ALK was expressed and that normal ALK genes remained silent.     ///    Anaplastic large cell lymphoma with the t(2;5)(p23;q35) NPM/ALK chromosomal translocation and duplication of the short arm of the non-translocated chromosome 2 involving the full length of the ALK gene.. '), ('10235', 'IGH_CCND1', 't(11;14)(q13;q32) / t(11;14)  / ', 'IGH', 'CCND1', '19963117', '124', 'prolymphocytic leukemia', 'ISH', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Fluorescence in situ hybridization analyses demonstrated no rearrangement of the immunoglobulin heavy-chain (IGH) (14q32) locus as well as of the cyclin D1 (CCND1) gene, suggesting that this is not the typical t(11;14) resulting from the CCND1/IGH fusion.     ///    Detection of the t(11;14)(q13;q32) without CCND1/IGH fusion in a case of acute myeloid leukemia.. '), ('10236', 'TPR_MET', 't(1;7)(q23;q32) / ', 'TPR', 'MET', '3282234', '123', 'cystic fibrosis\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'One allele is the previously characterized TPR-MET oncogene and the other is found on a der(7)t(1;7)(q23;q32) marker chromosome.     ///    These results demonstrate that the TPR-MET oncogene rearrangement involving chromosomes 1 and 7 is either due to an insertion of TPR sequences into the MET locus or is more complex.     ///    \"Using somatic cell hybrids, we show that the chromosome containing the TPR-MET oncogene is grossly rearranged and contains both the upstream and downstream portions of the MET protooncogene locus. \"'), ('10237', 'DFFA_CASZ1', '1p36.22 / ', 'DFFA', 'CASZ1', '26898937', '123', 'bladder cancer\r\r', '', '', '', '', '', '', '', '', 'Chromosomal rearrangements of regions 17q25, 15q26.3 and 1p36.22 resulting in the fusion transcripts SEPT9/CYHR, IGF1R/TTC23 and CASZ1/DFFA, appeared to be rare or unique events because they were not detected in the 48 UC samples.     ///    \"Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer. \"'), ('10238', 'IGH_BCL3', 't(14;19)(q32;q13) / t(14;19)  / ', 'IGH', 'BCL3', '21502423', '122', 'chronic lymphocytic leukemia;leukemia;lymphoma\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Fluorescence in situ hybridization demonstrated IGH@/BCL3 fusion gene in all cases. '), ('10239', 'JAK2_BCR', 'p24;q11.2 / t(9;22) / ', 'JAK2', 'BCR', '22549126', '121', 'myeloproliferative disorder;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', 'A rare translocation, t(9;22)(p24;q11.2), resulting in a novel BCR-JAK2 fusion has been reported in a handful of cases of CML and acute myelogenous leukemia (AML).     ///    BCR-JAK2 fusion as a result of a translocation (9;22)(p24;q11.2) in a patient with CML-like myeloproliferative disease..     ///    We present clinical-pathological and cytogenetic evaluation of a patient with Philadelphia-chromosome negative CML/MPD harboring a t(9;22)(p24;q11.2) resulting in BCR-JAK2 fusion.     ///    \"Fluorescence in situ hybridization and molecular characterization of the translocation confirmed a BCR-JAK2 fusion and helped delineate the breakpoints upstream of exon 1 of minor cluster region of BCR gene and likely intron 18 of the JAK2 gene, resulting in an in-frame transcript This case provides convincing support, along with two previous case-reports, for a role for activation of the Janus kinase 2 in evolution of myeloproliferative disease. \"'), ('10240', 'IGH_BCL11A', 't(2;14)(p16;q32) / t(2;14) (p16;q32) / ', 'IGH', 'BCL11A', '19369625', '121', 'chronic lymphocytic leukemia;leukemia;lymphoma\r\r', 'ISH', '', '', '', '', '', '', '', 'We conclude that CLL/SLL with t(2;14) (p16;q32) and BCL11A/IgH rearrangement is characterized by atypical morphologic features and unmutated IgV(H) genes..     ///    Fluorescence in situ hybridization analysis revealed BCL11A/IgH rearrangement in all. '), ('10241', 'SYT_SSX2', 'p11;q11 / ', 'SYT', 'SSX2', '9846971', '120', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'A subsequent sequence analysis using the polymerase chain reaction products confirmed that the detected messages were derived from either the SYT-SSX1 (22 cases) or SYT-SSX2 (8 cases) fusion gene.     ///    \"Fusion transcripts were detectable in all the 7 biphasic tumors analysed, one of which had an SYT-SSX2 fusion transcript. \"'), ('10242', 'SYT_SSX', 'p11.2;q11.2 / ', 'SYT', 'SSX', '21234732', '120', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Our results suggest that the fusion gene SYT-SSX should be considered to play important role on SS cell growth via ERK pathway.     ///    \"Meanwhile, down-regulation of SYT-SSX fusion gene expression would inhibit the proliferation of SS cell and the survival rate decreased (34.1%), while apoptotic rate increased (10.92%). \"    ///    This study may be valuable for understanding the pathogenic role and molecular mechanism of the fusion gene SYT-SSX in synovial sarcoma through the proposed genome-wide approach.     ///    \"In TMA stain assessment, SYT-SSX positive group with high ki-67 LI expressed more cyclin D1and CDK4 than the SYT-SSX negative group. \"    ///    The mRNA level reduced over 90% caused by SYT-SSX specific siRNA.     ///    The effect of SYT-SSX and extracellular signal-regulated kinase (ERK) on cell proliferation in synovial sarcoma..     ///    \"Furthermore, the research would open up the possibility of using SYT-SSX and ERK as a therapeutic target.. \"    ///    \"The protein level of ERK1/2, p-ERK, and cyclin D1 altered in same trend with expression of SYT-SSX. \"    ///    We evaluated the whole genome expression in SYO-1 cells inhibited as a result of specific small interfering RNA for SYT-SSX. '), ('10243', 'IGK_CDK6', 't(2;7)(p11;q21) / t(7;14)(q21;q32) / t(7;22)(q21;q11) / ', 'IGK', 'CDK6', '24726269', '119', 'lymphoproliferative disorder\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', 'Translocation t(2;7)(p11;q21) associated with the CDK6/IGK rearrangement is a rare but recurrent abnormality in B-cell lymphoproliferative malignancies.. '), ('10244', 'RARA_PML', 't(3;17)(p25;q21) / ', 'RARA', 'PML', '20633765', '117', 'acute promyelocytic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', 'KB', 'Seq', 'Cryptic insertion of PML-RARA into the 3p25 locus in an acute promyelocytic leukemia with t(3;17)(p25;q21).. '), ('10245', 'RUNX1T1_RUNX1', 't(8;21)(q22;q22) / t(8;21) / t(8;21)  / ', 'RUNX1T1', 'RUNX1', '24342949', '116', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', ' The oncogenic fusion protein AML1-ETO, also known as RUNX1-RUNX1T1 is generated by the t(8;21)(q22;q22) translocation, one of the most frequent chromosomal rearrangements in acute myeloid leukemia (AML).     ///    All together our data suggest that the upregulation of PONTIN by AML1-ETO participate in the oncogenic growth of t(8;21) cells.     ///    \"Moreover, transcriptome analysis in Kasumi-1 cells revealed a strong correlation between PONTIN and AML1-ETO gene signatures and demonstrated that PONTIN chiefly regulated the expression of genes implicated in cell cycle progression. \"    ///    \"Interestingly, AML1-ETO promoted the transcription of PONTIN. \"    ///    Our previous studies showed that Drosophila provides a genuine model to study how AML1-ETO promotes leukemia. '), ('10246', 'P15_P12', 'inv(4) / ', 'P15', 'P12', '16556609', '116', '', '', '', '', '', '', '', '', '', 'An inversion inv(4)(p12-p15.3) in autistic siblings implicates the 4p GABA receptor gene cluster..     ///    \" We describe the case of two brothers diagnosed with autism who both carry a paracentic inversion of the short arm of chromosome 4 (46,XY, inv(4)(p12-p15.3)). \"'), ('10247', 'FLI_EWS', 't(11;22) / t(11;22)(q24;q12) / ', 'FLI', 'EWS', '11890993', '115', 'ewing sarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', 'EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22).. '), ('10248', 'MALT1_API2', 't(11;18)(q21;q21) / t(11;18)  / t(11;18) / ', 'MALT1', 'API2', '16512826', '115', 'MALT lymphoma', '', '', '', '', '', '', '', '', ' t(11;18)(q21;q21) occurs specifically in mucosa-associated lymphoid tissue (MALT) lymphoma and the translocation generates a functional API2-MALT1 fusion product that activates nuclear factor (NF)kappaB. '), ('10249', 'FUS_CREB3L2', 't(7;16)(q33;p11) / ', 'FUS', 'CREB3L2', '21658743', '115', 'synovial sarcoma;osteosarcoma;sarcoma\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', 'Subsequently, it was discovered to carry the recurrent chromosomal translocation t(7;16)(q33;p11) encoding a FUS-CREB3L2 fusion oncoprotein. '), ('10250', 'BCR_ABL1', 't(9;22)  / ', 'BCR', 'ABL1', '23171293', '115', 'leukemia;sarcoma;lymphoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Fluorescence in situ hybridization performed on paraffin sections confirmed that both T-lymphoblast and myeloblast populations were positive for the t(9;22) BCR/ABL1 translocation. '), ('10251', 'IGH_FGFR3', 't(4;14)  / ', 'IGH', 'FGFR3', '21442194', '115', 'plasma cell tumor\r\r', 'ISH', 'Kinase', '', '', '', '', '', '', 'An extensive fluorescent in situ hybridization analysis showed the tumor to be negative for the t(4;14) FGFR3/IGH translocation as well as translocations involving the IGH,                         IGL, IGK, CCND1, BCL2, BCL6 and C-MYC genes. '), ('10252', 'DUX4_CIC', '', 'DUX4', 'CIC', '26800124', '115', 'ewing sarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', 'Round cell sarcoma with CIC-DUX4 gene fusion: Discussion of the distinctive cytomorphologic, immunohistochemical, and molecular features in the differential diagnosis of round cell tumors..     ///    \"Although a subset defined by recurrent CIC-DUX4 gene fusion has been recently characterized, data regarding the cytomorphologic features are currently limited. \"    ///    CIC-DUX4 round cell sarcoma differs from Ewing sarcoma in that it has more atypical cytologic features and lacks the diffuse membranous CD99 staining pattern characteristic of Ewing sarcoma.     ///    \"Focal-to-multifocal CD99 immunoreactivity and diffuse nuclear WT1 positivity is characteristic of CIC-DUX4 sarcoma, and should prompt molecular testing. \"    ///    Fluorescence in situ hybridization demonstrated CIC-DUX4 fusion in both cases. '), ('10253', 'KMT2A_FLNA', '', 'KMT2A', 'FLNA', '25892123', '114', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Subsequent molecular analysis showed a novel variant form of the previously described KMT2A-FLNA fusion gene, in which the KMT2A intron 9 is fused to the FLNA exon?16.     ///    A new variant of KMT2A(MLL)-FLNA fusion transcript in acute myeloid leukemia with ins(X;11)(q28;q23q23).. '), ('10254', 'SEC31A_ALK', '', 'SEC31A', 'ALK', '25715771', '111', 'non small cell lung cancer;non small cell lung cancer\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', '', 'SEC31A-ALK Fusion Gene in Lung Adenocarcinoma..     ///    \"In this study, we found a new ALK fusion gene, SEC31A-ALK, in lung carcinoma from a 53-year-old Korean man. \"    ///    \"This is the first report of SEC31A-ALK fusion transcript in clinical NSCLC, which could be a novel diagnostic and therapeutic target for patients with NSCLC.. \"    ///    Fluorescence in situ hybridization studies suggested that SEC31A-ALK was generated by an unbalanced genomic rearrangement associated with loss of the 3\'-end of SEC31A.     ///    \"SEC31A-ALK encodes a predicted fusion protein of 1,438 amino acids comprising the WD40 domain of SEC31A at the N-terminus and ALK kinase domain at the C-terminus.\"    ///    \"SEC31A-ALK encodes a predicted fusion protein of 1,438 amino acids comprising the WD40 domain of SEC31A at the N-terminus and ALK kinase domain at the C-terminus. \"'), ('10255', 'EML4_ALK', '', 'EML4', 'ALK', '19386350', '111', 'non small cell lung cancer;squamous cell carcinoma;adenocarcinoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', ' Recently, the fusion gene EML4-ALK was identified in non-small cell lung carcinoma, which could be a potential therapeutic target.     ///    Anaplastic lymphoma kinase immunohistochemistry may have utility as a screening tool or as a surrogate marker for the molecular techniques to detect the EML4-ALK fusion gene in these tumors..     ///    \"In conclusion, anaplastic lymphoma kinase immunoreactivity in non-small cell lung carcinomas was associated with transcriptional up-regulation, ALK locus rearrangement, and the presence of EML4-ALK fusion transcript. \"    ///    The presence of EML4-ALK fusion transcript was confirmed in 2 cases by reverse transcriptase-polymerase chain reaction.     ///    Florescence in situ hybridization for the ALK locus and reverse transcriptase-polymerase chain reaction for EML4-ALK were performed on tumors positive for anaplastic lymphoma kinase by immunohistochemistry. '), ('10256', 'HIP1_ALK', '', 'HIP1', 'ALK', '24496003', '111', 'non small cell lung cancer;squamous cell carcinoma;non small cell lung cancer;small cell lung cancer\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', '', 'Two ALK-rearranged NSCLC PDX models were identified: one carried a well-known EML4-ALK variant 3a/b and the other harbored a novel huntingtin interacting protein 1 (HIP1)-ALK fusion gene. '), ('10257', 'STRN_PDGFRA', 't(2;4)(p24;q12) / t(4;12) / t(2;4)  / ', 'STRN', 'PDGFRA', '17555450', '111', '', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Molecular analysis revealed a novel STRN-PDGFRA fusion for the t(2;4) and ETV6-PDGFRA for the t(4;12). '), ('10258', 'PDGFRA_FIP1L1', 't(2;4)(p24;q12) / t(4;12) / t(2;4)  / ', 'PDGFRA', 'FIP1L1', '17555450', '111', '', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', ' We identified two patients with a t(2;4)(p24;q12) and a t(4;12)(q2?3;p1?2), respectively, in association with BCR-ABL and FIP1L1-PDGFRA negative chronic eosinophilic leukaemia. ');
INSERT INTO `ChimerPub_dump` VALUES ('10259', 'PDGFRA_ETV6', 't(2;4)(p24;q12) / t(4;12) / t(2;4)  / ', 'PDGFRA', 'ETV6', '17555450', '111', '', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Molecular analysis revealed a novel STRN-PDGFRA fusion for the t(2;4) and ETV6-PDGFRA for the t(4;12). '), ('10260', 'FUS_CREB3L1', 't(7,16) (q32-34;p11) / t(11,16) (p11;p11) /  / ', 'FUS', 'CREB3L1', '17721195', '110', 'sarcoma', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', ' Low-grade fibromyxoid sarcomas (LGFMS) bear either the t(7,16) (q32-34;p11) or t(11,16) (p11;p11) translocations, resulting in FUS-CREB3L2 or FUS-CREB3L1 fusions, respectively.     ///    \"In conclusion, FUS-CREB3L1/L2 fusion transcripts can be detected in paraffin-embedded LGFMS in a sensitive manner, using reverse transcription-polymerase chain reaction. \"    ///    \"In conclusion, FUS-CREB3L1/L2 fusion transcripts can be detected in paraffin-embedded LGFMS in a sensitive manner, using reverse transcription-polymerase chain reaction.\"    ///    \"Of all, 48/59 (sensitivity, 81%) LGFMS contained detectable transcripts (45 FUS-CREB3L2, 3 FUS-CREB3L1). \"'), ('10261', 'FUS_CREB3L2', 't(7,16) (q32-34;p11) / t(11,16) (p11;p11) /  / ', 'FUS', 'CREB3L2', '17721195', '110', 'sarcoma', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', ' Low-grade fibromyxoid sarcomas (LGFMS) bear either the t(7,16) (q32-34;p11) or t(11,16) (p11;p11) translocations, resulting in FUS-CREB3L2 or FUS-CREB3L1 fusions, respectively.     ///    \"Low-grade fibromyxoid sarcomas (LGFMS) bear either the t(7,16) (q32-34;p11) or t(11,16) (p11;p11) translocations, resulting in FUS-CREB3L2 or FUS-CREB3L1 fusions, respectively.\"    ///    \"Of all, 7/52 non-LGMFS neoplasms contained FUS-CREB3L2 transcripts, of which 4 had been diagnosed as sclerosing epithelioid fibrosarcoma. \"    ///    \"Of all, 48/59 (sensitivity, 81%) LGFMS contained detectable transcripts (45 FUS-CREB3L2, 3 FUS-CREB3L1). \"    ///    \"Of all, 7/52 non-LGMFS neoplasms contained FUS-CREB3L2 transcripts, of which 4 had been diagnosed as sclerosing epithelioid fibrosarcoma.\"'), ('10262', 'NUT_BRD4', 't(15;19) / ', 'NUT', 'BRD4', '25512383', '110', '', '', 'Kinase', '', '', '', '', 'KB', '', ' NUT midline carcinoma (NMC) is a rare but highly aggressive cancer typically caused by the translocation t(15;19), which results in the formation of the BRD4-NUT fusion oncoprotein.     ///    Mechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation..     ///    \"However, the mechanistic details of this BRD4-NUT function remain poorly understood. \"    ///    \"We also discovered that, in BRD4-NUT expressed in NMC cells, the NUT moiety of the fusion protein anchored to chromatin by the double bromodomains also stimulates histone hyperacetylation, which causes BRD4 to bind tighter to chromatin. \"'), ('10263', 'BCR_ABL1', '', 'BCR', 'ABL1', '24740226', '110', 'chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', ' The BCR-ABL1 fusion gene, the causative lesion of chronic myeloid leukemia (CML) in >95 % of newly presenting patients, offers both a therapeutic and diagnostic target.     ///    Real-time quantification assay to monitor BCR-ABL1 transcripts in chronic myeloid leukemia.. '), ('10264', 'GOT1_ETV6', 't(10;12)(q24;p13) / t(10;12) (q24;p13) / t(10;12) / ', 'GOT1', 'ETV6', '18310541', '108', 'myelodysplastic syndrome\r\r', 'ISH', '', '', '', '', '', '', '', 'ETV6/GOT1 fusion in a case of t(10;12)(q24;p13)-positive myelodysplastic syndrome..     ///    \" The ETV6/GOT1 fusion, resulting from t(10;12) (q24;p13), has been recently described in a myelodysplastic syndrome. \"    ///    We reported a second case of t(10;12)-positive myelodysplastic syndrome in whom fluorescent in situ hybridization confirmed the non-random translocation but molecular biology analyses revealed a ETV6/GOT1 chimera varying from the first case described.. '), ('10265', 'BCR_ABL1', 't(9;22)  / ', 'BCR', 'ABL1', '19479611', '108', 'chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'patients with submicroscopic deletion in the fusion region ABL/BCR of the sole t(9;22) vs. '), ('10266', 'BCR_ABL1', '', 'BCR', 'ABL1', '9352747', '107', 'leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Philadelphia (Ph) chromosome formation results in the relocation of the ABL oncogene from the chromosome 9q34 to BCR region on 22q11, forming the BCR/ABL fusion gene. '), ('10267', 'STRN_ALK', '', 'STRN', 'ALK', '26848800', '107', 'renal cell carcinoma;sickle cell trait', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Two Cases of Renal Cell Carcinoma Harboring a Novel STRN-ALK Fusion Gene..     ///    \"ALK translocation was confirmed by fluorescent in situ hybridization, and further gene analysis revealed a STRN-ALK fusion. \"    ///    \"Here, we describe 2 cases of RCC harboring a novel striatin (STRN)-ALK fusion. \"'), ('10268', 'NPM_MLF1', 't(3;5)  / ', 'NPM', 'MLF1', '10393836', '106', 'acute myeloid leukemia;anaplastic large cell lymphoma;acute promyelocytic leukemia;myeloid leukemia \r\r', 'ISH', '', '', '', '', '', '', '', ' The NPM-MLF1 fusion protein is expressed in blasts from patients with myelodysplasia/acute myeloid leukemia (MDS/AML) containing the t(3;5) chromosomal rearrangement.     ///    \"Mlf1 transcripts were undetectable in the lympho-hematopoietic organs of both the embryonic and adult mouse, suggesting that NPM-MLF1 contributes to the genesis of MDS/AML in part by enforcing the ectopic overexpression of MLF1 within hematopoietic tissues.. \"'), ('10269', 'MYC_IGH', 't(8;14)  / ', 'MYC', 'IGH', '21239197', '106', 'non Hodgkin lymphoma;B cell lymphoma;lymphoma\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Fluorescent in situ hybridization analysis for MYC/IGH (immunoglobulin heavy chain) rearrangement t(8;14) identified fusion signals, confirming the presence of MYC rearrangement.     ///    We were able to demonstrate the MYC/IGH rearrangement in our case of PBL. '), ('10270', 'MYCN_MYCC', '17p13.3 / ', 'MYCN', 'MYCC', '15328187', '105', 'medulloblastoma', 'ISH', '', 'Oncogene', '', '', '', '', '', 'Loss of 17p13.3 (38% of medulloblastomas) was found across all of the histopathological variants, whereas MYCC/MYCN amplification (6%/8% of medulloblastomas) was significantly associated with the large cell/anaplastic phenotype. '), ('10271', 'PS1_SHMT', '1p32.3 / 17p11.2 / ', 'PS1', 'SHMT', '8786078', '105', '', '', '', '', '', '', '', '', '', 'Two phage clones containing SHMT-ps1 have been mapped by fluorescence in situ hybridisation to 1p32.3-33.     ///    The complete SHMT-ps1 sequence of 2538 nt is bounded by two 16 nt direct repeats that are characteristic of retroelement insertion sites.     ///    We have isolated phage clones containing human genomic sequences homologous to cytosolic SHMT and have found these to contain a processed pseudogene (SHMT-ps1) with a 90% identity to cloned SHMT cDNAs.     ///    SHMT-ps1 contains 2335 nt that are homologous to SHMT but it has an additional leader sequence of 203 nt of unknown origin. '), ('10272', 'PDGFB_COL1A1', 't(17;22) (q22;q13) / t(17;22)  / ', 'PDGFB', 'COL1A1', '20569296', '105', 'dermatofibrosarcoma protuberans;sarcoma\r\r', 'ISH', '', 'Oncogene', '', '', '', 'KB', '', ' Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma of the skin characterized by the presence of specific COL1A1-PDGFB fusion protein, which appears as a consequence of the t(17;22) (q22;q13) translocation. '), ('10273', 'MALT1_API2', 't(11;18)(q21;q21) / ', 'MALT1', 'API2', '24868477', '105', 'colonic diverticulitis;MALT lymphoma', 'ISH', '', '', '', '', '', '', '', 'Fluorescence in situ hybridization studies revealed API2-MALT1 fusion signals consistent with t(11;18)(q21;q21), which confirmed the diagnosis of extranodal marginal zone lymphoma, also known as mucosa associated lymphoid tissue lymphoma. '), ('10274', 'TSC2_PKD1', '3p25.5 / 16p13.3 / ', 'TSC2', 'PKD1', '10619258', '105', 'breast cancer;ductal carcinoma\r\r', '', '', '', 'Tumor_suppressor', '', '', '', '', 'Among informative in situ and invasive apocrine carcinomas, LOH was present in 33% of 15 cases for 17p13 (TP53), as well as 36% of 14 cases for 3p25 (VHL), 30% of 10 cases for 1p35-36 (NB), and 27% of 11 cases for 16p13.3 (TSC2/PKD1).     ///    \"LOH was performed at a number of chromosomal loci, including loci commonly altered in breast cancer: 1p35-36 (NB), 3p25.5 (VHL), 8p12 (D8S136), 9p21 (p16), 11p13 (D11S904), 11q13 (INT-2 and PYGM), 16p13.3 (TSC2/PKD1 gene region), 17p13 (TP53), 17q13 (NM23), and 22q12 (D22S683). \"    ///    \"Loss of heterozygosity is detected at chromosomes 1p35-36 (NB), 3p25 (VHL), 16p13 (TSC2/PKD1), and 17p13 (TP53) in microdissected apocrine carcinomas of the breast.. \"    ///    \"An intermediate frequency of allelic loss was detected at multiple tumor suppressor gene loci, including 17p13 (TP53), as well as 1p35-336 (NB), 3p25 (VHL), and 16p13 (PKD1/ TSC2), in apocrine carcinomas of the breast, with a higher overall frequency of LOH noted among invasive tumors compared with in situ tumors. \"'), ('10275', 'NEU_ERBB2', '17p13.3 / ', 'NEU', 'ERBB2', '9259397', '105', 'breast cancer\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'In this study, node-negative (N-) tumors were examined for TP53 allelic loss in relation to different genetic instability events, including allelic loss at chromosome 17p13.3 and c-H-ras-1 loci, as well as alteration of the c-myc and c-erbB-2/neu oncogenes.     ///    \"13%, 8%, 9% and 3% for LOH at D17S30 and c-H-ras-1 loci, and amplification of c-myc and c-erbB-2/neu respectively). \"'), ('10276', 'BCR_ABL1', '', 'BCR', 'ABL1', '17215855', '104', 'myeloproliferative disorder;chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'In CML the BCR-ABL1 fusion gene was detected in CD34+/CD133+ cells, granulo-monocytes, eosinophils, erythrocytes, megakaryocytes and B-lymphocytes.     ///    FIP1L1-PDGFRA in chronic eosinophilic leukemia and BCR-ABL1 in chronic myeloid leukemia affect different leukemic cells..     ///    \"Fluorescence in situ hybridization specific for BCR-ABL1 and for FIP1L1-PDGFRA was combined with cytomorphology or with lineage-restricted monoclonal antibodies and applied in CML and CEL, respectively. \"    ///    \"This study provided evidence for marked differences in the leukemic masses which are targeted by imatinib in CEL or CML, as harboring FIP1L1-PDGFRA or BCR-ABL1.. \"'), ('10277', 'NUP214_ABL1', '', 'NUP214', 'ABL1', '18923437', '104', 'T ALL\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia..     ///     Episomes with the NUP214-ABL1 fusion gene have been observed in 6% of T-ALL.     ///    One case showed insertion of apparently non-amplified NUP214-ABL1 sequences at 14q12.     ///    The amplified sequences were analyzed using array-based CGH.These findings confirm that the NUP214-ABL1 gene requires amplification for oncogenicity.     ///    Fluorescent in situ hybridization revealed a heterogeneous pattern of NUP214-ABL1 amplification. '), ('10278', 'RUNX1T1_RUNX1', '', 'RUNX1T1', 'RUNX1', '23358744', '104', 'acute myeloid leukemia;acute promyelocytic leukemia;myeloid leukemia;leukemia\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', 'A prerequisite for individualized treatment strategies is a fast pretherapeutic molecular screening including the fusion genes PML-RARA, RUNX1-RUNX1T1 and CBFB-MYH11 as well as mutations in the genes NPM1, FLT3 and CEBPA. '), ('10279', 'PARP15_AHSG', '', 'PARP15', 'AHSG', '24135866', '104', 'hepatocellular carcinoma\r\r', '', '', '', '', '', '', '', '', 'Within these variants, new isoforms of NIR and fusion genes PARP15-AHSG caught our attention for their potential roles in cancer development. '), ('10280', 'FUS_CREB3L1', '', 'FUS', 'CREB3L1', '16287497', '104', 'sarcoma\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', 'It was not possible to detect the FUS/CREB3L2 and FUS/CREB3L1 fusion genes from the formalin-fixed and paraffin-embedded tissue, although the histological features of the present case were typical of LGFMS. '), ('10281', 'FUS_CREB3L2', '', 'FUS', 'CREB3L2', '16287497', '104', 'sarcoma\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', 'It was not possible to detect the FUS/CREB3L2 and FUS/CREB3L1 fusion genes from the formalin-fixed and paraffin-embedded tissue, although the histological features of the present case were typical of LGFMS. '), ('10282', 'MUM1_IRF4', 't(1;6) / t(1;6)  / del(11) / 1p35.3 / 6p25.2 / ', 'MUM1', 'IRF4', '15510210', '104', 'B cell chronic lymphocytic leukemia', 'ISH', '', 'Oncogene', 'Tumor_suppressor', '', 'Transcription_Factor', '', '', 'The latter breakpoint was located in the genomic region coding for MUM1/IRF4, one of the key regulators of lymphocyte development and proliferation, suggesting involvement of this gene in the t(1;6). '), ('10283', 'RUNX1_ETO', '', 'RUNX1', 'ETO', '23054644', '104', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'The mutations of TP53 and the fusion genes RUNX1/ETO, CBF?/MYH11, and PML/RAR? were all negative. '), ('10284', 'SYT_SSX', '', 'SYT', 'SSX', '10737705', '104', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Specificity was demonstrated on COS-7 cells transfected with two subtypes of SYT-SSX fusion genes, SYT-SSX1 and SYT-SSX2.     ///    \" To identify and characterize the SYT-SSX fusion proteins in synovial sarcomas, we developed two polyclonal antibodies against the N-terminal part and for the C-terminal part of the SYT-SSX2 protein. \"    ///    These antibodies provide a useful method for studying the expression of the SYT-SSX fusion proteins..     ///    \"An immunohistochemical study, using human synovial sarcoma tissues, demonstrated that the SYT-SSX fusion proteins localized in the nucleus of the tumor cells. \"    ///    SYT-SSX fusion proteins in synovial sarcomas: detection and characterization with new antibodies.. '), ('10285', 'SLMAP_NTRK2', '', 'SLMAP', 'NTRK2', '26810070', '104', 'pilocytic astrocytoma\r\r', '', 'Kinase', '', '', '', '', '', '', 'Despite a detailed analysis, novel genetic alterations were limited to two fusion genes, EWSR1-PATZ1 and SLMAP-NTRK2, both in gangliogliomas. '), ('10286', 'SYT_SSX2', '', 'SYT', 'SSX2', '10737705', '104', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Specificity was demonstrated on COS-7 cells transfected with two subtypes of SYT-SSX fusion genes, SYT-SSX1 and SYT-SSX2.     ///    \" To identify and characterize the SYT-SSX fusion proteins in synovial sarcomas, we developed two polyclonal antibodies against the N-terminal part and for the C-terminal part of the SYT-SSX2 protein. \"'), ('10287', 'PATZ1_EWSR1', '', 'PATZ1', 'EWSR1', '26810070', '104', 'pilocytic astrocytoma\r\r', '', '', '', '', '', '', 'KB', '', 'Despite a detailed analysis, novel genetic alterations were limited to two fusion genes, EWSR1-PATZ1 and SLMAP-NTRK2, both in gangliogliomas. '), ('10288', 'RARA_PML', '', 'RARA', 'PML', '23358744', '104', 'acute myeloid leukemia;acute promyelocytic leukemia;myeloid leukemia;leukemia\r\r', '', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', 'KB', 'Seq', 'A prerequisite for individualized treatment strategies is a fast pretherapeutic molecular screening including the fusion genes PML-RARA, RUNX1-RUNX1T1 and CBFB-MYH11 as well as mutations in the genes NPM1, FLT3 and CEBPA. '), ('10289', 'RANBP2_ALK', '', 'RANBP2', 'ALK', '23345154', '104', 'sarcoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', '', 'Fluorescence in situ hybridization revealed that the Ran-binding protein 2-ALK fusion gene was present. '), ('10290', 'CREB_ATF', '17p13.3 / ', 'CREB', 'ATF', '12296377', '104', '', '', '', '', '', '', '', '', '', 'The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene..     ///    We have shown that the interaction of an ATF/CREB element (-38 to -31) and its cognate transcription factors play a predominant role in the promoter activity of the RNMTL1 gene.     ///    \"Finally, we reported a novel mechanism underlying the YY1 mediated transcription repression, namely, the ATF/CREB dependent transcription-repression by YY1 is executed in absence of its own sequence-specific binding.. \"    ///    The secondary DNA structures of the ATF/CREB element play a more vital role in the protein-DNA interaction. '), ('10291', 'PDGFRA_FIP1L1', '', 'PDGFRA', 'FIP1L1', '16387954', '104', 'bronchitis;gastrointestinal diseases', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'The presence of the FIP1L1-PDGFRA fusion gene in myeloid cells was confirmed by fluorescence in situ hybridisation analysis using CHIC2 deletion as a surrogate marker.     ///    Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity..     ///    This is the first case of persistent cough caused by hypereosinophilic syndrome characterised by FIP1L1-PDGFRA fusion gene and aberrant tyrosine kinase activity.. '), ('10292', 'RUNX1_ETV6', '', 'RUNX1', 'ETV6', '21224468', '104', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', ' Approximately 25% of childhood acute lymphoblastic leukemias carry the ETV6/RUNX1 fusion gene.     ///    ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling..     ///    Fluorescence in situ hybridization screening of additional 24 relapsed and 72 nonrelapsed ETV6/RUNX1-positive cases demonstrated that BMF deletions were significantly more common in relapse cases (16.6% vs 2.8%.     ///    These findings implicate glucocorticoid-associated drug resistance in ETV6/RUNX1-positive relapse pathogenesis and therefore might help to guide future therapies.. '), ('10293', 'PENK_BGAL11', '', 'PENK', 'BGAL11', '7996174', '104', '', 'ISH', '', '', '', '', '', '', '', 'A human proenkephalin-beta-galactosidase fusion gene has previously been shown to give correct phenotypic expression and appropriate stress regulation within the hypothalamus of transgenic mice. '), ('10294', 'SYT_SSX1', '', 'SYT', 'SSX1', '10737705', '104', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Specificity was demonstrated on COS-7 cells transfected with two subtypes of SYT-SSX fusion genes, SYT-SSX1 and SYT-SSX2. '), ('10295', 'STAT6_NAB2', '', 'STAT6', 'NAB2', '25582503', '103', 'solitary fibrous tumor\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', 'We examined variations of the NAB2-STAT6 fusion gene in 40 cases of SFT using formalin-fixed, paraffin-embedded tissues and secondary genetic alterations of tumor protein p53 (TP53),, platelet-derived growth factor receptor, ? polypeptide (PDGFRB), and telomerase reverse transcriptase (TERT) promoters.     ///    Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential..     ///    NAB2-STAT6 fusions were detected in all of the cases. '), ('10296', 'ERK2_ERK1', 't(9;11)(p22;q23) / t(9;11)  / ', 'ERK2', 'ERK1', '18931459', '103', 'acute myeloid leukemia;myeloid leukemia;leukemia;hematologic malignancy\r\r', '', '', '', '', '', '', '', '', 'Therefore, since MM6 cell line has a similar expression profile to primary human t(9;11) AML in general and expresses uniquely a strong Erk1/Erk2 MAPK pathway including HRAS, it can be used as a model for HRAS-positive t(9;11) AML..     ///    \"The majority of alternatively expressed genes in MM6 were involved in biosynthetic and metabolic processes, but HRAS, a protein that is known to be associated with leukemogenesis, was expressed only in MM6 cells and several other genes involved in Erk1/Erk2 MAPK pathway were also over-expressed in MM6. \"'), ('10297', 'NFIB_MYB', '', 'NFIB', 'MYB', '25951887', '103', 'cylindroma', 'ISH', '', '', '', '', '', 'KB', '', 'Fluorescence in situ hybridization, reverse transcription-polymerase chain reaction, immunohistochemistry and whole-exome sequencing revealed absence of the MYB-NFIB fusion gene, low levels of MYB protein expression and a clonal somatic CYLD splice site mutation associated with loss of heterozygosity of the wild-type allele.     ///    \" The aims of this study were to perform a whole-exome sequencing analysis of a breast cylindroma and to investigate the role of molecular analyses in the differentiation between breast cylindroma, a benign tumour that displays MYB expression, and CYLD gene mutations, and its main differential diagnosis, the breast solid-basaloid adenoid cystic carcinoma, a malignant tumour that is characterized by the presence of the MYB-NFIB fusion gene and MYB overexpression. \"'), ('10298', 'EWSR1_ATF1', 't(12;22)(q13;q12) / ', 'EWSR1', 'ATF1', '21185830', '102', 'clear cell sarcoma;sarcoma\r\r', 'ISH', '', '', '', '', 'Transcription_Factor', 'KB', 'Seq', ' The most common recurrent translocation in clear cell sarcoma t(12;22)(q13;q12) results in an EWSR1/ATF1 chimeric gene.     ///    Discovery of two novel EWSR1/ATF1 transcripts in four chimerical transcripts-expressing clear cell sarcoma and their quantitative evaluation.    ///    Reverse transcription-polymerase chain reaction analysis revealed the presence of four different EWSR1/ATF1 chimerical transcripts in the tumor sample as well as in both metastatic lymph nodes.    ///    Discovery of two novel EWSR1/ATF1 transcripts in four chimerical transcripts-expressing clear cell sarcoma and their quantitative evaluation.. '), ('10299', 'TMPRSS2_ERG', '', 'TMPRSS2', 'ERG', '19584163', '101', 'prostate cancer\r\r', 'ISH', '', '', '', '', '', 'KB', 'Seq', 'We sought to determine the prevalence of TMPRSS2-ERG gene fusion among prostate-specific antigen-screened men undergoing prostate biopsy in the United States.     ///    \"These findings indicate a need for prospective studies to evaluate the relationship of TMPRSS2-ERG rearrangement with clinical course of screening-detected prostate cancer in North American men, and a need for the development of noninvasive screening tests to detect TMPRSS2-ERG rearrangement.. \"    ///    This is the first prospective North American multicenter study to characterize TMPRSS2-ERG prostate cancer prevalence in a cohort of patients undergoing needle biopsy irrespective of whether or not they subsequently undergo prostatectomy. '), ('10300', 'Immunoglobulin _BCL2', 't(14;18)(q32;q21) / t(14;18)  / ', 'Immunoglobulin ', 'BCL2', '2834197', '101', '', '', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', ' The most common translocation in human lymphoma, the t(14;18)(q32;q21), generates heterogeneous 4.2-7.2 kb Bcl-2-immunoglobulin (Ig) chimeric mRNAs resulting from alternative Bcl-2 5\' exons and varied Ig 3\' untranslated regions (UT). '), ('10301', 'IGF2_H19', '11p15.5 / ', 'IGF2', 'H19', '10196374', '100', '', 'ISH', '', '', '', '', '', '', '', 'The close juxtaposition of reciprocally imprinted genes has also been seen in other imprinted regions, such as human 11p15.5/Mmu7 ( H19 / Igf2 ) and suggests that the two genes may be co-regulated. '), ('10302', 'PDGFRA_FIP1L1', '', 'PDGFRA', 'FIP1L1', '17988989', '99', 'leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', ' Imatinib is highly effective for the treatment of chronic eosinophilic leukemia (CEL) caused by the FIP1L1-PDGFRA fusion gene.     ///    \"Reverse transcriptase-polymerase chain reaction and sequencing analyses revealed a FIP1L1-PDGFRA fusion transcript with FIP1L1 intron 10 fused to PDGFRA exon 12, and fluorescent in situ hybridization analysis confirmed the interstitial deletion in chromosome 4q12. \"    ///    \"Fortunately, the FIP1L1-PDGFRA fusion transcript had become undetectable, and imatinib treatment was stopped. \"'), ('10303', 'SYT_SSX', '', 'SYT', 'SSX', '19385976', '99', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', ' The present study aimed to describe the distribution and features of the SYT-SSX fusion gene in Chinese patients with synovial sarcoma (SS), and to analyze the prognostic value of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in SS.     ///    The prognostic implication of SYT-SSX fusion type and clinicopathological parameters were analyzed by univariate and multivariate survival analyses.     ///    \"However, SYT-SSX fusion type was not associated with local recurrence-free survival (P = 0.216). \"    ///    \"Prognostic implication of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in synovial sarcoma.. \"'), ('10304', 'EML4_ALK', '', 'EML4', 'ALK', '26767032', '98', '', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Our data was apparently inconsistent with the traditional view that the EML4-ALK fusion gene in patients is resistant to EGFR-TKIs..     ///    Two patients harboring both EGFR mutation and EML4-ALK rearrangement were detected in this study.     ///    \"The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) rearrangement is almost in mutual exclusion to epidermal growth factor receptor (EGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations, with rare exceptions.\"    ///    \" The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) rearrangement is almost in mutual exclusion to epidermal growth factor receptor (EGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations, with rare exceptions. \"'), ('10305', 'NUT_NSD3', '', 'NUT', 'NSD3', '25466466', '97', '', 'ISH', '', '', '', '', '', '', '', 'Fluorescence in situ hybridization confirmed the NSD3-NUT gene rearrangement, whereas a BRD3/4-NUT fusion gene was not detected. '), ('10306', 'NUP98_HOXA9', 't(2;11)(q31;p15) / ', 'NUP98', 'HOXA9', '9766650', '95', 'leukemia\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', 'The NUP98-HOXD13 fusion is structurally similar to the NUP98-HOXA9 fusion previously identified in patients with AML, leading to the speculation that NUP98-homeobox gene fusions may be oncogenic. '), ('10307', 'EBP_C/EBP', 't(12;16)  / ', 'EBP', 'C/EBP', '9624148', '92', 'liposarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', ' Human translocation liposarcoma (TLS)-CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) is a fusion oncoprotein found specifically in a malignant tumor of adipose tissue and results from a t(12;16) translocation that fuses the amino-terminal part of TLS to the entire coding region of CHOP.     ///    Human translocation liposarcoma-CCAAT/enhancer binding protein (C/EBP) homologous protein (TLS-CHOP) oncoprotein prevents adipocyte differentiation by directly interfering with C/EBPbeta function.. '), ('10308', 'HLF_E2A', 't(17;19) / ', 'HLF', 'E2A', '10023025', '90', 'leukemia\r\r', 'ISH', '', 'Oncogene', '', '', '', '', '', 'Ectopic expression of HLF as an E2A-HLF fusion protein in t(17;19)-positive human pro-B cell acute lymphoblastic leukemias is believed to promote malignancy by interfering with apoptosis. '), ('10309', 'SYT_SSX2', '', 'SYT', 'SSX2', '10718206', '88', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', '18), resulting in either the SYT-SSX1 or SYT-SSX2 gene fusion.     ///    Approximately two thirds of the tumors had an SYT-SSX1 and one third had an SYT-SSX2 fusion transcript.     ///    \"Tumors with SYT-SSX2 had a significantly higher mean and median Ki-67 labeling index than those with SYT-SSX1, but a comparison of Ki-67 according to fusion type, histologic type, and sample source suggested that the main determinants of proliferation rate were the latter two factors. \"    ///    \"All biphasic synovial sarcomas had the SYT-SSX1 fusion, whereas all tumors with SYT-SSX2 were of monophasic morphology. \"'), ('10310', 'SYT_SSX1', '', 'SYT', 'SSX1', '10718206', '88', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', '18), resulting in either the SYT-SSX1 or SYT-SSX2 gene fusion.     ///    Approximately two thirds of the tumors had an SYT-SSX1 and one third had an SYT-SSX2 fusion transcript.     ///    \"Tumors with SYT-SSX2 had a significantly higher mean and median Ki-67 labeling index than those with SYT-SSX1, but a comparison of Ki-67 according to fusion type, histologic type, and sample source suggested that the main determinants of proliferation rate were the latter two factors. \"    ///    \"All biphasic synovial sarcomas had the SYT-SSX1 fusion, whereas all tumors with SYT-SSX2 were of monophasic morphology. \"'), ('10311', 'PBX1_E2A', 't(1;19)  / ', 'PBX1', 'E2A', '9366523', '86', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', '', '', '', '', '', 'Transcription_Factor', '', '', 'The leukemogenic transcription factor gene E2A-PBX1 is created through fusion of the genes E2A and PBX1 as a result of t(1;19) in acute lymphoblastic leukemia.     ///    \"Co-transfection of Hoxb7, a homeodomain protein capable of enhancing DNA binding by PBX1, impaired COD formation, suggesting that CODs contain E2A-PBX1 protein not associated with DNA. \"    ///    \"We conclude that, as a \'gain of function\' phenomenon requiring protein elements from both E2A and PBX1, COD formation may be relevant to the biology of E2A-PBX1 in leukemogenesis.. \"'), ('10312', 'C11orf95_RELA', '', 'C11orf95', 'RELA', '25989737', '86', 'ependymoma\r\r', '', '', '', '', '', 'Transcription_Factor', '', '', 'Oncogenic c11orf95/RELA fusion gene formation is characteristic for a subgroup of patients with supratentorial ependymoma. '), ('10313', 'MALT1_API2', 't(11;18)(q21;q21) / ', 'MALT1', 'API2', '15337797', '84', 'MALT lymphoma;lymphoma\r\r', '', '', '', '', '', '', '', '', 'The presence of t(11;18)(q21;q21) was identified by a multiplex reverse transcriptase polymerase chain reaction of the API2-MALT1 chimeric transcript.     ///    The API2-MALT1 fusion transcript was detected in only one (12.5%) of eight H. '), ('10314', 'FLI_EWS', '', 'FLI', 'EWS', '9463579', '83', 'neuroectodermal tumor', '', '', '', '', '', '', '', '', 'A chimeric transcript of the EWS/FLI-1 fusion gene detected by a nested reverse transcriptase-polymerase chain reaction using formalin-fixed paraffin-embedded tissue justified the diagnosis of pPNET. '), ('10315', 'NPM_ALK', 't(2;5)(p23;q35) / t(2;5)  / ', 'NPM', 'ALK', '11607814', '83', 'non Hodgkin lymphoma;anaplastic large cell lymphoma;lymphoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Much confusion about the exact classification and clinicopathological features of this subgroup of NHL was clarified with the identification of NPM-ALK (nucleophosmin-anaplastic lymphoma kinase) as the oncogene created by the t(2;5) (Morris et al., 1994).     ///    \"With the discovery of NPM-ALK as the specific lymphoma gene mutation, this NHL subtype could be redefined on the molecular level. \"'), ('10316', 'RABGAP1L_NTRK1', '', 'RABGAP1L', 'NTRK1', '24563076', '75', 'cholangiocarcinoma\r\r', '', 'Kinase', '', '', '', '', '', '', 'Four (14%) of the ICC cases featured novel gene fusions involving the tyrosine kinases FGFR2 and NTRK1 (FGFR2-KIAA1598, FGFR2-BICC1, FGFR2-TACC3, and RABGAP1L-NTRK1). '), ('10317', 'KIAA1598_FGFR2', '', 'KIAA1598', 'FGFR2', '24563076', '75', 'cholangiocarcinoma\r\r', '', 'Kinase', '', '', '', '', '', '', 'Four (14%) of the ICC cases featured novel gene fusions involving the tyrosine kinases FGFR2 and NTRK1 (FGFR2-KIAA1598, FGFR2-BICC1, FGFR2-TACC3, and RABGAP1L-NTRK1). '), ('10318', 'TPR_NTRK1', '', 'TPR', 'NTRK1', '26367451', '75', 'thyroid nodule;thyroid carcinoma\r\r', '', 'Kinase', '', '', '', '', 'KB', '', 'These gene fusions included ETV6/NTRK3 (n=3) and TPR/NTRK1 (n=1). '), ('10319', 'TACC3_FGFR2', '', 'TACC3', 'FGFR2', '24563076', '75', 'cholangiocarcinoma\r\r', '', 'Kinase', '', '', '', '', '', '', 'Four (14%) of the ICC cases featured novel gene fusions involving the tyrosine kinases FGFR2 and NTRK1 (FGFR2-KIAA1598, FGFR2-BICC1, FGFR2-TACC3, and RABGAP1L-NTRK1). '), ('10320', 'MLLT1_MLL', 't(11;19) / ', 'MLLT1', 'MLL', '26164398', '74', 'leukemia;hematologic malignancy\r\r', 'ISH', '', 'Oncogene', '', '', '', 'KB', 'Seq', 'The KMT2A (MLL)-MLLT1 gene rearrangement was confirmed by multiplex reverse transcriptase polymerase chain reaction.     ///    \"KMT2A (MLL) rearrangements are observed in various types of pediatric and adult leukemia, but only one adult case report has so far showed KMT2A (MLL)-MLLT1 gene rearrangements in BPDCN. \"    ///    We suggest that the pathogenesis of BPDCN could be associated with KMT2A (MLL) rearrangement (especially with KMT2A (MLL)-MLLT1) and further study on a larger number of cases is needed.     ///    We present the first pediatric case of BPDCN with a KMT2A (MLL)-MLLT1 rearrangement confirmed by molecular study.     ///    KMT2A (MLL)-MLLT1 rearrangement in blastic plasmacytoid dendritic cell neoplasm.. '), ('10321', 'EWSR1_CREB1', 't(12;22)(q13;q12) / ', 'EWSR1', 'CREB1', '18300804', '70', 'clear cell sarcoma;malignant meningioma;microphthalmia', '', '', '', '', '', 'Transcription_Factor', 'KB', '', 'Reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues demonstrated transcripts of the EWSR1-ATF1 (31/33) or EWSR1-CREB1 fusion gene (2/33).     ///    \"In addition, the tumors occurring in the gastrointestinal tract may have a variant fusion gene EWSR1-CREB1. \"'), ('10322', 'TNNI2_SYT8', '1p36.22 / ', 'TNNI2', 'SYT8', '26898937', '67', 'bladder cancer\r\r', '', '', '', '', '', '', '', '', 'Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.     ///    \"In contrast, the SYT8/TNNI2 fusion transcript resulting from transcription-induced chimerism by read-through mechanisms was a rather common and tumor-specific event occurring in 37.5% (18/48) of the UC specimens. \"'), ('10323', 'HES_CEL', 'del(4)(q12q12) / ', 'HES', 'CEL', '17591942', '66', 'leukemia;hypereosinophilic syndrome\r\r', 'ISH', '', '', '', '', '', '', '', 'Recently, a new acquired mutation was described in approximately 50% of the HES/CEL patients: a cryptic deletion on chromosome band 4q12 generating a FIP1L1-PDGFRA fusion gene. '), ('10324', 'CREB1_ATF1', 't(12;22)(q13;q12) / ', 'CREB1', 'ATF1', '18300804', '66', 'clear cell sarcoma;malignant meningioma;microphthalmia', '', '', '', '', '', 'Transcription_Factor', '', '', 'In cases with unusual histologic findings, molecular detection of the EWSR1-ATF1/CREB1 fusion genes provides critical information regarding the diagnosis of the tumor.. '), ('10325', 'HMGA2_C9orf92', 't(9;12)(p22;q14) / ', 'HMGA2', 'C9orf92', '26857357', '65', '', 'ISH', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'The HMGA2-C9orf92 fusion transcript would code for a putative protein containing amino acid residues 1-94 of HMGA2 and 6 amino acid residues from the out-of-frame fusion with exon 4 of C9orf92. '), ('10326', 'ETV6_ABL1', 't(9;12)  / t(9;12) / del(9) / ', 'ETV6', 'ABL1', '18656692', '65', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'The cell line expressed ETV6/ABL1 fusion transcripts and displayed sensitivity to imatinib with an IC(50) of 0.1 microM.     ///    Establishment and cytogenetic characterization of a human acute lymphoblastic leukemia cell line (ALL-VG) with ETV6/ABL1 rearrangement..     ///    ETV6/ABL1 and BCR/ABL1 FK display similar activity but they may not be identical in function.     ///    The ALL-VG cell line may serve as a tool for the study of ETV6/ABL1..     ///    \"Here we present the generation of an ETV6/ABL1 positive human acute lymphoblastic leukemia (ALL) cell line, ALL-VG. \"    ///    \"ETV6/ABL1 fusion was demonstrated to result from insertion of a duplicated 300 to 1300 kb region of 9q34 that contained the distal portion of the ABL1 gene, into the ETV6 locus on 12p13. \"'), ('10327', 'FUS_CHOP', 't(12;16) / ', 'FUS', 'CHOP', '7485386', '64', 'liposarcoma;ewing sarcoma;fibrous histiocytoma;sarcoma;histiocytoma\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'However, the TLS/FUS-CHOP fusion transcripts were not detected in two pleomorphic liposarcomas or in three myxoid variants of malignant fibrous histiocytomas.     ///    \"Our findings indicate that in liposarcomas TLS/FUS-CHOP fusion transcripts have variations at the junction of chimeric messages, which was the case for Ewing\'s sarcoma. \"    ///    Chimeric TLS/FUS-CHOP gene expression and the heterogeneity of its junction in human myxoid and round cell liposarcoma..     ///    This translocation causes fusion of these genes resulting in the expression of a novel chimeric TLS/FUS-CHOP message. '), ('10328', 'NPM_ALK', 't(2;5)  / t(2;5)(p23;q35) / t(2;5) / ', 'NPM', 'ALK', '9598798', '64', 'anaplastic large cell lymphoma;lymphoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', 'Two extranodal lesions had NPM/ALK fusion transcripts detected by nested reverse transcriptase-polymerase chain reaction. '), ('10329', 'SYT_SSX1', 'p11.2;q11.2 / ', 'SYT', 'SSX1', '10862210', '64', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'The hazard ratio for metastasis associated with the SYT-SSX1 fusion transcripts was 7 (95% CI 1.5-36, log-rank p = 0.004).     ///    Type of fusion transcripts (SYT-SSX1 or SYT-SSX2) and Ki-67 were assessed in fresh frozen tissue from 33 patients.     ///    \"Large tumor size, local recurrence, histologic Grade IV, MIB1 index > or = 10 and possibly SYT-SSX1 fusion transcript were associated with impaired clinical outcome.. \"    ///    The 5-year metastasis-free survival for patients with SYT-SSX1 was 42% versus 89% for those with SYT-SSX2.     ///    There was a significant association between SYT-SSX1 and high tumor proliferation rate. '), ('10330', 'SYT_SSX2', 'p11.2;q11.2 / ', 'SYT', 'SSX2', '10862210', '64', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Type of fusion transcripts (SYT-SSX1 or SYT-SSX2) and Ki-67 were assessed in fresh frozen tissue from 33 patients.     ///    The 5-year metastasis-free survival for patients with SYT-SSX1 was 42% versus 89% for those with SYT-SSX2. '), ('10331', 'EWSR1_PBX1', 't(1;22)(q21;q12) / / ', 'EWSR1', 'PBX1', '23681076', '63', 'myoepithelioma\r\r', 'ISH', '', '', '', '', 'Transcription_Factor', 'KB', '', 'Cytogenetic studies conducted on 1 tumor showed 46,XY,t(1;22)(q21;q12) associated with EWSR1-PBX1 fusion.    ///    \"Cytogenetic studies conducted on 1 tumor showed 46,XY,t(1;22)(q21;q12) associated with EWSR1-PBX1 fusion. \"'), ('10332', 'Immunoglobulin _CCND1', '', 'Immunoglobulin ', 'CCND1', '15272540', '63', 'mantle cell lymphoma', 'ISH', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Fluorescence in situ hybridization studies demonstrated cyclin D1-immunoglobulin heavy chain gene fusion in both components. '), ('10333', 'TMPRSS2_ERG', '', 'TMPRSS2', 'ERG', '24931216', '61', 'prostate cancer\r\r', '', '', '', '', '', '', 'KB', 'Seq', 'Further, we demonstrate concurrent in situ detection of gene expression, point mutations, and gene fusions of the prostate cancer relevant targets AMACR, AR, TP53, and TMPRSS2-ERG. '), ('10334', 'SYT_SSX1', 'p11;q11 / ', 'SYT', 'SSX1', '9846971', '58', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'A subsequent sequence analysis using the polymerase chain reaction products confirmed that the detected messages were derived from either the SYT-SSX1 (22 cases) or SYT-SSX2 (8 cases) fusion gene.     ///    \"Of 23 SYT-SSX-positive monophasic tumors, 16 tumors had an SYT-SSX1 fusion transcript. \"'), ('10335', 'BCR_ABL1', '', 'BCR', 'ABL1', '25183062', '58', 'glioblastoma multiforme', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', ' The extraordinary success of imatinib in the treatment of BCR-ABL1 associated cancers underscores the need to identify novel functional gene fusions in cancer. '), ('10336', 'RET_PTC1', '', 'RET', 'PTC1', '24417340', '57', 'thyroid carcinoma;thyloid cancer\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Eighty percent of tumors undergoing mutational analysis had the BRAF(V600E) mutation, and the remaining 20% harbored a RET/PTC1 gene rearrangement.     ///    \"Strikingly, all tumors in our series harbored a PTC-associated genetic abnormality, either a BRAF(V600E) mutation (80%) or a RET/PTC1 rearrangement (20%). \"'), ('10337', 'RET_PTC', '', 'RET', 'PTC', '20012784', '57', 'papillary carcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas..     ///    \"Screening for BRAF, RET, KRAS, NRAS, and HRAS mutations, as well as RET-PTC1 and RET-PTC3 rearrangements, was performed on paraffin-embedded material from 17 of these dominant nodules. \"    ///    \"No BRAF or RAS mutations or RET-PTC rearrangements were identified in a dominant nodule, including those with atypical, worrisome histopathologic features. \"'), ('10338', 'RARA_PML', 't(5;17)  / t(15;17)(q23;q12) / t(11;17)(q23;q12) / t(5;17)(q32;q12) / del(5q) / del(8q)  / t(11;17) / ', 'RARA', 'PML', '8605120', '53', 'acute promyelocytic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', 'KB', 'Seq', 'Whereas RARA rearrangement appears sufficient for an APL-like phenotype, it seems that the presence of a classical PML/RARA is required for typical APL with response to ATRA..     ///    Molecular studies evidenced RARA rearrangement but showed neither PML rearrangement nor PML/RARA fusion. '), ('10339', 'SYT_SSX1', 'p11.2;q11.2 / ', 'SYT', 'SSX1', '18720326', '53', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'The positive detection of the SYT-SSX1 fusion transcripts with reverse-transcription polymerase chain reaction in formalin-fixed and paraffin-embedded tissue confirmed the synovial sarcoma diagnosis.. '), ('10340', 'FLI_EWS', 't(11;22)(q24;q12) / t(11;22) / ', 'FLI', 'EWS', '8644855', '53', 'ewing sarcoma;rhabdomyosarcoma;neuroectodermal tumor;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', 'Is the EWS/FLI-1 fusion transcript specific for Ewing sarcoma and peripheral primitive neuroectodermal tumor? A report of four cases showing this transcript in a wider range of tumor types.. '), ('10341', 'NPM_MLF1', 't(3;5)  / t(3;5)(q21;q34) / ', 'NPM', 'MLF1', '9595039', '52', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', '', '', 'Molecular analysis of this case, however, failed to show rearrangement of the NPM gene and an MLF1/NPM transcript. '), ('10342', 'ETO_CDR', 't(16;21)  / t(16;21)(q24;q22) / t(8;21)  / t(8;21) / ', 'ETO', 'CDR', '9596646', '51', 'leukemia\r\r', '', '', '', '', '', '', '', '', 'The structural analysis of the cDNAs showed that AML1 was fused to a novel gene named MTG16 (Myeloid Translocation Gene on chromosome 16) which shows high homology to MTG8 (ETO/CDR) and MTGR1. '), ('10343', 'SYT_SSX2', '', 'SYT', 'SSX2', '10935650', '49', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX2 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma. '), ('10344', 'EML4_ALK', '', 'EML4', 'ALK', '24496003', '49', 'non small cell lung cancer;squamous cell carcinoma;non small cell lung cancer;small cell lung canc\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Two ALK-rearranged NSCLC PDX models were identified: one carried a well-known EML4-ALK variant 3a/b and the other harbored a novel huntingtin interacting protein 1 (HIP1)-ALK fusion gene.     ///    \"Screening of 99 lung cancer PDX models by the NanoString ALK fusion assay identified two ALK-rearranged non-small-cell lung cancer (NSCLC) tumors, including one harboring a previously known echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion and another containing an unknown ALK fusion variant. \"'), ('10345', 'SYT_SSX1', '', 'SYT', 'SSX1', '19805961', '49', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Primary endobronchial synovial sarcoma confirmed by SYT-SSX1 fusion gene transcript by reverse transcriptase polymerase chain reaction..     ///    \"A subsequent molecular analysis performed using reverse transcriptase-polymerase chain reaction with RNA extracted from paraffin-embedded tissue, revealed SYT/SSX1 fusion gene which confirmed the diagnosis of synovial sarcoma. \"'), ('10346', 'SYT_SSX', '', 'SYT', 'SSX', '10217560', '49', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Primary synovial sarcoma of the lung: report of two cases confirmed by molecular detection of SYT-SSX fusion gene transcripts..     ///    \"In both cases, a reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX fusion gene transcripts, which are characteristic of synovial sarcoma. \"    ///    Our molecular assay detecting the SYT-SSX fusion transcripts is useful for the final diagnosis of synovial sarcoma arising at such an unusual anatomical site.. '), ('10347', 'SYT_SSX', '', 'SYT', 'SSX', '18333330', '49', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX 1 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.. '), ('10348', 'NTRK1_NFASC', '', 'NTRK1', 'NFASC', '24647444', '46', 'glioblastoma multiforme\r\r', '', 'Kinase', '', '', '', '', '', '', 'Lentiviral transduction of the NFASC-NTRK1 fusion gene in NIH 3T3 cells increased proliferation in vitro, colony formation in soft agar, and tumor formation in mice, suggesting the possibility that the fusion contributed to the initiation or maintenance of the fusion-positive GBMs, and therefore may be a rational drug target. '), ('10349', 'SEPT6_MLL', '', 'SEPT6', 'MLL', '16843108', '44', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', 'KB', '', 'MLL-SEPT6 fusion transcript with a novel sequence in an infant with acute myeloid leukemia..     ///    \"Fluorescence in situ hybridization analysis suggested a possible break in the MLL gene, and molecular analysis using reverse transcriptase-polymerase chain reaction followed by sequencing confirmed the expression of an MLL-SEPT6 fusion transcript with a novel sequence. \"'), ('10350', 'NUP98_DDX10', 't(2;11)(q31;p15) / ', 'NUP98', 'DDX10', '9766650', '44', 'leukemia\r\r', 'ISH', '', '', '', '', '', 'KB', 'Seq', 'Moreover, this report, along with a recent study that demonstrated NUP98-DDX10 fusions in patients with t-AML, raises the possibility that NUP98 may be a previously unsuspected target for chromosomal translocations in patients with t-AML.. '), ('10351', 'MECT1_MAML2', '', 'MECT1', 'MAML2', '21526958', '42', 'adenoid cystic carcinoma;squamous cell carcinoma;mucoepidermoid carcinoma\r\r', 'ISH', '', '', '', '', '', '', '', 'Most mucoepidermoid carcinomas harbor MECT1-MAML2 gene rearrangement.    ///    Most mucoepidermoid carcinomas harbor MECT1-MAML2 gene rearrangement. '), ('10352', 'MYH11_CBFB', '', 'MYH11', 'CBFB', '23358744', '42', 'acute myeloid leukemia;acute promyelocytic leukemia;myeloid leukemia;leukemia\r\r', '', '', '', '', '', '', '', '', 'A prerequisite for individualized treatment strategies is a fast pretherapeutic molecular screening including the fusion genes PML-RARA, RUNX1-RUNX1T1 and CBFB-MYH11 as well as mutations in the genes NPM1, FLT3 and CEBPA. '), ('10353', 'MYB_QKI', '', 'MYB', 'QKI', '26810070', '42', 'pilocytic astrocytoma\r\r', '', '', '', '', '', '', '', '', 'In contrast, a MYB-QKI fusion characterized almost all angiocentric gliomas (87?%), and MYB fusion genes were the most common genetic alteration in DAs (41?%). '), ('10354', 'TCR_IGH', 't(14;18)  / ', 'TCR', 'IGH', '12653743', '42', 'extranodal NK/T-cell lymphoma', 'ISH', '', '', '', '', '', '', '', 'Our molecular data indicate that blastic NK-cell lymphoma cases lack clonal TCR/IgH gene rearrangements consistent with an NK-cell origin. '), ('10355', 'QKI_MYB', '', 'QKI', 'MYB', '26810070', '42', 'pilocytic astrocytoma\r\r', '', '', '', '', '', '', '', '', 'In contrast, a MYB-QKI fusion characterized almost all angiocentric gliomas (87?%), and MYB fusion genes were the most common genetic alteration in DAs (41?%). '), ('10356', 'YWHAE_FAM22A', 't(10;17)  / t(10;17) / ', 'YWHAE', 'FAM22A', '22223660', '39', 'endometrial stromal sarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', 'KB', '', 'Fluorescence in situ hybridization analysis demonstrated absolute specificity of YWHAE-FAM22A/B genetic rearrangement for high-grade ESS, with no fusions detected in other uterine and nonuterine mesenchymal tumors (55 tumor types, n = 827).     ///    \"Fluorescence in situ hybridization analysis demonstrated absolute specificity of YWHAE-FAM22A/B genetic rearrangement for high-grade ESS, with no fusions detected in other uterine and nonuterine mesenchymal tumors (55 tumor types, n = 827).\"'), ('10357', 'BCR_ABL1', 'p24;q11.2 / t(9;22) / ', 'BCR', 'ABL1', '22549126', '39', 'myeloproliferative disorder;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', '  Translocation (9;22)(q34;q11.2) resulting in BCR/ABL1 fusion at the molecular level is the hallmark of chronic myelogenous leukemia (CML). '), ('10358', 'BCR_ABL1', 't(9;22)  / ', 'BCR', 'ABL1', '22989955', '38', 'chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Fluorescence in situ hybridization revealed an unusual signal pattern  revealing the BCR-ABL1 fusion signal on chromosome 12, while no reciprocal ABL1-BCR fusion was detected on der(9) chromosome.     ///    Unusual location of BCR-ABL1 fusion sequences in a chronic myeloid leukemia patient..     ///    \"The relocation of BCR-ABL1 fusion sequences to 12p11 site in our patient represents a rare type of variant translocation, as in almost all patients  the chimeric BCR-ABL1 gene is located on der(22) chromosome. \"    ///     We describe a case of a chronic myeloid leukemia patient displaying the chimeric BCR-ABL1 gene on 12p11. '), ('10359', 'MTC_IGH', 't(11;14)  / ', 'MTC', 'IGH', '8729972', '38', 'lymphocytic lymphoma;non Hodgkin Lymphoma', '', '', '', '', '', '', '', '', 'The amplification products were also evaluated by Sst-I, Alu-I, Dde-I, and Ita-I restriction enzymes and showed different patterns of digestion reflecting individual differences between the MTC/ IgH junctions. '), ('10360', 'TMC1_C9orf3', '', 'TMC1', 'C9orf3', '26271415', '37', 'hepatocellular carcinoma', '', '', '', '', '', '', '', '', 'We also identified five common fusion genes between HCC and its corresponding PVTT samples, including ARID1A-GPATCH3, MDM1-NUP107, PTGES3-RARG, PRLR-TERT, and C9orf3-TMC1. '), ('10361', 'TERT_PRLR', '', 'TERT', 'PRLR', '26271415', '37', 'hepatocellular carcinoma', '', '', '', '', '', 'Transcription_Factor', '', '', 'We also identified five common fusion genes between HCC and its corresponding PVTT samples, including ARID1A-GPATCH3, MDM1-NUP107, PTGES3-RARG, PRLR-TERT, and C9orf3-TMC1. '), ('10362', 'helicase_DEAD', 't(11;14)(q23;q32) / ', 'helicase', 'DEAD', '8995487', '37', 'B cell lymphoma;lymphoma\r\r', 'ISH', '', '', '', '', '', '', '', 'DDX6 encodes a DEAD box protein/RNA helicase. '), ('10363', 'GPATCH3_ARID1A', '', 'GPATCH3', 'ARID1A', '26271415', '37', 'hepatocellular carcinoma', '', '', '', 'Tumor_suppressor', '', '', '', '', 'We also identified five common fusion genes between HCC and its corresponding PVTT samples, including ARID1A-GPATCH3, MDM1-NUP107, PTGES3-RARG, PRLR-TERT, and C9orf3-TMC1. '), ('10364', 'NUP107_MDM1', '', 'NUP107', 'MDM1', '26271415', '37', 'hepatocellular carcinoma', '', '', '', '', '', '', '', '', 'We also identified five common fusion genes between HCC and its corresponding PVTT samples, including ARID1A-GPATCH3, MDM1-NUP107, PTGES3-RARG, PRLR-TERT, and C9orf3-TMC1. '), ('10365', 'RARG_PTGES3', '', 'RARG', 'PTGES3', '26271415', '37', 'hepatocellular carcinoma', '', '', '', '', 'Receptor', 'Transcription_Factor', '', '', 'We also identified five common fusion genes between HCC and its corresponding PVTT samples, including ARID1A-GPATCH3, MDM1-NUP107, PTGES3-RARG, PRLR-TERT, and C9orf3-TMC1. '), ('10366', 'SEC31A_ALK', 't(2;3)(p23;q27) / / ', 'SEC31A', 'ALK', '20207848', '35', 'B cell lymphoma;lymphoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', '', 'ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions.    ///    \"Further studies of SEC31A-ALK showed that this variant fusion transforms IL3-dependent Ba/F3 cells to growth factor independence, and that the ALK inhibitor TAE-684 reduces cell proliferation and kinase activity of SEC31A-ALK and its downstream effectors ERK1/2, AKT, STAT3 and STAT5..\"'), ('10367', 'NPM1_ALK', 't(2;3)(p23;q27) / / ', 'NPM1', 'ALK', '20207848', '35', 'B cell lymphoma;lymphoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', 'ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions.'), ('10368', 'TPRG1_LPP', 't(3;6)(q27;p21) / ', 'TPRG1', 'LPP', '19963137', '35', '', '', '', '', '', '', '', '', '', 'Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues.. '), ('10369', 'BCR_ABL1', 't(9;22;20)(q34;q11;p13) / t(9;22;20)  / ', 'BCR', 'ABL1', '1958592', '35', 'chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'The close association of 5\'-BCR and 3\'-ABL was demonstrated by field inversion gel electrophoresis, and in situ hybridization showed that BCR-ABL was located on the short arm of chromosome 20. '), ('10370', 'LPP_HMGA2', 't(3;6)(q27;p21) / ', 'LPP', 'HMGA2', '19963137', '35', '', '', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', 'The biological function of this novel fusion could be similar to the role of HMGA2-LPP in tumorigenesis.. '), ('10371', 'TFE3_ASPSCR1', '', 'TFE3', 'ASPSCR1', '26516944', '35', 'alveolar soft part sarcoma', '', '', 'Oncogene', '', '', '', 'KB', '', 'Real-time polymerase chain reaction to detect the ASPSCR1-TFE3 fusion transcript on paraffin-embedded tissue blocks has been shown to be more sensitive and specific than detection of TFE3 by immunohistochemical stain.     ///    The recent discovery of the role of the ASPSCR1-TFE3 fusion protein in the MET proto-oncogene signaling pathway promoting angiogenesis and cell proliferation offers a promising targeted molecular therapy. '), ('10372', 'BCR_ABL1', 't(9;22) / ', 'BCR', 'ABL1', '25901138', '34', 'chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', ' Neutrophilic-chronic myelogenous leukemia (CML-N) is a rare chronic myelogenous leukemia (CML) variant characterized by BCR-ABL1 positive chronic neutrophilia. '), ('10373', 'ZNF_KOX', '10p11.2 / ', 'ZNF', 'KOX', '1639412', '34', 'multiple endocrine neoplasia\r\r', '', '', '', '', '', '', '', '', 'This cluster of ZNF/KOX genes is of particular interest since the loci for multiple endocrine neoplasia type 2A and 2B (MEN2A and MEN2B) syndromes have been assigned to this region by linkage analysis.. '), ('10374', 'BCR_ABL1', 't(9;12)  / t(9;12) / del(9) / ', 'BCR', 'ABL1', '18656692', '33', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'ETV6/ABL1 and BCR/ABL1 FK display similar activity but they may not be identical in function.     ///     Fusion kinases (FK) like BCR/ABL1 mediate leukemic transformation and represent therapeutic targets. '), ('10375', 'MYC_IGH', 't(8;14) / t(8;14)  / ', 'MYC', 'IGH', '20193852', '33', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Fluorescence in situ hybridization studies confirmed MYC/IGH fusion in 35% of nuclei, but the translocation was atypical due to lack of immunoglobulin heavy chain (IGH) gene disruption. '), ('10376', 'IGH_IL3', 't(5;14)(q31;q32) / ', 'IGH', 'IL3', '25382309', '33', 'lymphoma\r\r', '', '', '', '', '', '', '', '', 'Cutaneous B-lymphoblastic lymphoma with IL3/IgH translocation presenting with hypereosinophilia and acute endocarditis..     ///    \"Using fluorescent in situ hybridisation, we demonstrate IL3/IgH@ fusion in cutaneous lymphoma cells. \"'), ('10377', 'IGH_CCND1', 't(11;14)  / ', 'IGH', 'CCND1', '20062012', '33', 'mantle cell lymphoma', 'ISH', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Fluorescence in situ hybridization studies confirmed the presence of the CCND1/IGH translocation in the majority of mantle-cell lymphoma, but not in diffuse large B-cell lymphoma that expressed cyclin-D1 protein. '), ('10378', 'PDGFB_COL1A1', '', 'PDGFB', 'COL1A1', '19940748', '32', 'dermatofibrosarcoma protuberans;fibrous histiocytoma;sarcoma;histiocytoma\r\r', '', '', 'Oncogene', '', '', '', 'KB', '', 'None of the tumors harbored COL1A1-PDGFB fusion transcripts identified by reverse transcriptase-polymerase chain reaction.     ///    \"Although indeterminate fibrohistiocytic lesions share some features with DFSP, the lack of COL1A1-PDGFB chimeric transcripts suggests that they are distinct entities..\"    ///    COL1A1:PDGFB chimeric transcripts are not present in indeterminate fibrohistiocytic lesions of the skin..     ///    \"Because indeterminate fibrohistiocytic lesions share some features with DFSP, they were evaluated for the possible presence of COL1A1-PDGFB chimeric transcripts. \"    ///    Twelve formalin-fixed paraffin-embedded cases were examined for COL1A1-PDGFB chimeric transcripts using a previously validated sensitive multiplex reverse transcriptase-polymerase chain reaction assay.     ///    \"Although indeterminate fibrohistiocytic lesions share some features with DFSP, the lack of COL1A1-PDGFB chimeric transcripts suggests that they are distinct entities.. \"'), ('10379', 'KIAA1549_BRAF', '', 'KIAA1549', 'BRAF', '21696415', '32', 'pilocytic astrocytoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'The frequency of BRAF-KIAA1549 fusion transcripts is significantly lower in adult patients with pilocytic astrocytoma, weakening the sensitivity of this specific diagnostic marker in that age group..     ///    BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults..     ///     Duplication of 7q34 resulting in generation of BRAF-KIAA1549 fusion transcripts is a characteristic event in pilocytic astrocytoma that may also aid distinction from diffuse astrocytic tumours.     ///    \"As data on BRAF-KIAA1549 fusion transcript status remain mainly limited to children, we aimed to examine the diagnostic value of BRAF-KIAA1549 fusion transcripts across all age groups. \"    ///    BRAF-KIAA1549 fusion transcript status was examined using reverse transcription polymerase chain reaction on formalin-fixed paraffin-embedded samples of 105 primary pilocytic astrocytomas [median patient age: 17 years (1-74 years)]. '), ('10380', 'FUS_CHOP', '', 'FUS', 'CHOP', '12930346', '32', 'liposarcoma;sarcoma\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Myxoid liposarcoma confirmed by TLS/FUS-CHOP fusion transcripts..     ///    \" Described here is the use of detecting TLS/FUS-CHOP fusion transcripts to confirm the diagnosis of a myxoid liposarcoma by nested reverse transcription-polymerase chain reaction assay using archival formalin-fixed, paraffin-embedded tissues of a young man with a benign-looking myxoid tumor on his upper extremity, which is often misdiagnosed clinically or histopathologically as a benign tumor.. \"'), ('10381', 'ASPSCR1_TFE3', '', 'ASPSCR1', 'TFE3', '21835426', '32', 'granular cell tumors', '', '', 'Oncogene', '', '', '', 'KB', 'Seq', 'Technique for differentiating alveolar soft part sarcoma from other tumors in paraffin-embedded tissue: comparison of immunohistochemistry for TFE3 and CD147 and of reverse transcription polymerase chain reaction for ASPSCR1-TFE3 fusion transcript.    ///    \"In non-alveolar soft part sarcoma tumors, the ASPSCR1-TFE3 fusion transcript was not detected; however, the TFE3 immunoreactivity was observed in 2 of 5 granular cell tumors.\"    ///    \"Three important characteristics of alveolar soft part sarcoma, the presence of ASPSCR1-TFE3 fusion transcript, nuclear immunoreactivity for TFE3, and immunoreactivity for monocarboxylate transporter 1 and CD147, have recently been reported.\"    ///    \"Thus, detection of the ASPSCR1-TFE3 fusion transcript was considered applicable for formalin-fixed, paraffin-embedded tissues with superior sensitivity as compared with TFE3 immunohistochemical staining. \"    ///    \"To identify the best marker for alveolar soft part sarcoma in formalin-fixed, paraffin-embedded tissues, we evaluated the sensitivity and specificity of the detection of the ASPSCR1-TFE3 fusion transcript along with the immunoreactivity for TFE3 and CD147 in 24 alveolar soft part sarcomas and 23 non-alveolar soft part sarcoma tumors, including 5 granular cell tumors, 5 paragangliomas, 3 clear cell sarcomas, and 10 clear cell renal cell carcinomas. \"    ///    \"The ASPSCR1-TFE3 fusion transcript was detected in 24 of 24 alveolar soft part sarcomas (7 type 1, 17 type 2), and TFE3 immunoreactivity was observed in 22 of 24 alveolar soft part sarcomas. \"    ///    Our results demonstrate that the most sensitive marker of alveolar soft part sarcoma was the presence of the ASPSCR1-TFE3 fusion transcript.     ///    \"Three important characteristics of alveolar soft part sarcoma, the presence of ASPSCR1-TFE3 fusion transcript, nuclear immunoreactivity for TFE3, and immunoreactivity for monocarboxylate transporter 1 and CD147, have recently been reported. \"    ///    Technique for differentiating alveolar soft part sarcoma from other tumors in paraffin-embedded tissue: comparison of immunohistochemistry for TFE3 and CD147 and of reverse transcription polymerase chain reaction for ASPSCR1-TFE3 fusion transcript..     ///    \"In alveolar soft part sarcomas with unusual locations or histology, we consider that the detection of the ASPSCR1-TFE3 fusion transcript would be the highly effective diagnostic technique.. \"    ///    \"In non-alveolar soft part sarcoma tumors, the ASPSCR1-TFE3 fusion transcript was not detected. \"'), ('10382', 'PDGFB_COL1A1', '', 'PDGFB', 'COL1A1', '11272901', '32', 'dermatofibrosarcoma,', '', '', 'Oncogene', '', '', '', 'KB', '', 'Our results verify that the COL1A1-PDGFB fusion transcripts are preserved in the FS areas of most DFSP-FSs.     ///    COL1A1-PDGFB fusion transcripts in fibrosarcomatous areas of six dermatofibrosarcomas protuberans..     ///    \"The COL1A1-PDGFB fusion transcripts could be detected in FS areas in five of the six cases, whereas conventional DFSP areas of all cases expressed the chimeric mRNA. \"    ///    \"As the chimeric gene, COL1A1-PDGFB, has been proposed to play an important role in the histogenesis of DFSP, we conducted a reverse transcription-polymerase chain reaction assay to ascertain whether the COL1A1-PDGFB fusion transcripts can be detected in both conventional DFSP and fibrosarcomatous components of DFSP with fibrosarcomatous areas (DFSP-FS), using a simple method of microdissection on sections of archival formalin-fixed, paraffin-embedded tumor specimens from six DFSP-FS cases. \"'), ('10383', 'FUS_CHOP', '', 'FUS', 'CHOP', '10584701', '32', 'liposarcoma;fibrous histiocytoma;sarcoma;histiocytoma\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'In a nested reverse transcription-polymerase chain reaction analysis using archival paraffin-embedded tissue, it was seen that none of the eight tumors with myxoid MFH-like features had TLS/FUS-CHOP fusion transcripts characteristic of myxoid and round cell liposarcomas. '), ('10384', 'SYT_SSX1', '', 'SYT', 'SSX1', '19385976', '32', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'SYT-SSX1 and SYT-SSX2 fusion transcripts were tested by reverse transcription-polymerase chain reaction in 141 formalin-fixed, paraffin-embedded SS.     ///    \"Moreover, SYT-SSX1 was an adverse predictor for disease-specific survival and metastasis-free survival, but had no relation to local recurrence-free survival. \"    ///    \"SYT-SSX1 (risk ratio [RR] = 2.032, P = 0.004), larger tumor size (RR = 1.859, P = 0.008), and aggressive F?d?ration Nationale des Centers de Lutte Contre le Cancer grade (RR = 2.094, P = 0.001) were adverse predictors for disease-specific survival. \"    ///    \"SYT-SSX1 and SYT-SSX2 were detected in 50 (34.5%) and 91 (64.5%) tumors, respectively. \"    ///    \"In conclusion, compared to SYT-SSX1, SYT-SSX2 was more frequent in Chinese patients with SS. \"    ///    \"Besides, SYT-SSX1 (RR = 1.859, P = 0.037), older age (RR = 1.799, P = 0.040), and aggressive International Union Against Cancer stage (RR = 3.690, P < 0.001) proved to be adverse prognostic factors for metastasis-free survival. \"');
INSERT INTO `ChimerPub_dump` VALUES ('10385', 'SYT_SSX', '', 'SYT', 'SSX', '15105652', '32', 'rhabdoid tumor', '', '', '', '', '', '', '', '', 'A subset of adult rhabdoid tumors may be a rhabdoid variant of synovial sarcoma, and molecular studies to detect SYT-SSX fusion transcripts are recommended for an accurate diagnosis.. '), ('10386', 'TMPRSS2_ERG', '', 'TMPRSS2', 'ERG', '23695551', '32', 'prostate cancer\r\r', '', '', '', '', '', '', 'KB', 'Seq', 'TMPRSS2-ERG was the most recurrent rearrangement present in eight cases, in both GP3 and GP4. '), ('10387', 'SYT_SSX', '', 'SYT', 'SSX', '11937885', '32', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Intraarticular synovial sarcoma confirmed by SYT-SSX fusion transcript..     ///     A case of intraarticular synovial sarcoma arising in the knee verified by detection of the tumor-specific SYT-SSX fusion transcript is described. '), ('10388', 'SYT_SSX', '', 'SYT', 'SSX', '10191774', '32', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', ' Identification of the SYT-SSX fusion transcript can be a useful diagnostic aid for synovial sarcoma.     ///    Detection of SYT-SSX fusion transcript in synovial sarcoma using archival cytologic specimens..     ///    The SYT-SSX transcript was identified in 10 (91%) of 11 of cytologic and 9 (75%) of 12 histologic cases. '), ('10389', 'SYT_SSX2', '', 'SYT', 'SSX2', '19385976', '32', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'SYT-SSX1 and SYT-SSX2 fusion transcripts were tested by reverse transcription-polymerase chain reaction in 141 formalin-fixed, paraffin-embedded SS.     ///    \"SYT-SSX1 and SYT-SSX2 were detected in 50 (34.5%) and 91 (64.5%) tumors, respectively. \"    ///    \"In conclusion, compared to SYT-SSX1, SYT-SSX2 was more frequent in Chinese patients with SS. \"'), ('10390', 'DUS4L_BCAP29', '', 'DUS4L', 'BCAP29', '24240688', '32', 'gastric cancer\r\r', '', '', '', '', '', '', '', '', 'A novel DUS4L-BCAP29 fusion transcript was found in 2 out of 12 cell lines and 10 out of 13 gastric cancer tissues.     ///    Knockdown of DUS4L-BCAP29 transcript using siRNA inhibited cell proliferation. '), ('10391', 'PDGFB_COL1A1', '', 'PDGFB', 'COL1A1', '21570152', '32', 'dermatofibrosarcoma protuberans;sarcoma\r\r', '', '', 'Oncogene', '', '', '', 'KB', '', 'No association was found between the different COL1A1-PDGFB fusion transcripts and the different histologic subtypes.     ///    The COL1A1-PDGFB fusion transcript was found in 100% DFSP-FS and 72% DFSP.     ///    \"Dermatofibrosarcoma protuberans: a clinicopathological, immunohistochemical, genetic (COL1A1-PDGFB), and therapeutic study of low-grade versus high-grade (fibrosarcomatous) tumors.. \"    ///    COL1A1-PDGFB is a useful tool for diagnosis of DFSP and particularly for DFSP-FS.. '), ('10392', 'ETV6_ABL1', '', 'ETV6', 'ABL1', '15789067', '32', 'myeloproliferative disorder\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Broad molecular screening of an unclassifiable myeloproliferative disorder reveals an unexpected ETV6/ABL1 fusion transcript.. '), ('10393', 'TIP39_PTH2R', '', 'TIP39', 'PTH2R', '15297442', '31', '', 'ISH', '', '', '', 'Receptor', '', '', '', 'Because the mammalian PTH2R was also most abundantly expressed in these tissues, the TIP39-PTH2R system may serve conserved physiological roles in mammals and fishes.. '), ('10394', 'NKG2_CD94', '', 'NKG2', 'CD94', '17505822', '31', '', 'ISH', '', '', '', '', '', '', '', 'Like CD94/NKG2 gene found in teleostean fishes, chicken CD94/NKG2 has the features of both human CD94 and NKG2A.     ///    Chicken CD69 and CD94/NKG2-like genes in a chromosomal region syntenic to mammalian natural killer gene complex.. '), ('10395', 'RARA_MPO', '', 'RARA', 'MPO', '1701231', '31', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', '', '', 'We report: (i) that the respective position of the five genes is centromere - c-erbA-1 - G-CSF - c-erbB-2 - RAR alpha - MPO - telomere.     ///    (iii) that the breakpoints are consistently located between c-erbB-2 and RAR alpha/MPO in M3. '), ('10396', 'HIF1_ALDC', '', 'HIF1', 'ALDC', '22923632', '31', 'endometrial cancer', '', '', '', '', '', '', '', '', 'To test the association between ALDC /HIF1? protein using immunohistochemistry (IHC) (positive and negative) and the clinical parameters, Fisher\'s exact test was performed for categorical parameters and the logistic regression model was used for continuous ones. '), ('10397', 'MYC_TGFA', '', 'MYC', 'TGFA', '10233843', '31', 'hepatocellular carcinoma\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Here we analyze chromosomal alterations in 11 hepatocellular carcinomas from the c-myc/TGF-alpha double-transgenic mice by fluorescent in situ hybridization with whole chromosome probes, single-copy genes, and 4\'-6-diamidino-2-phenylindole (DAPI-) and G-banded chromosomes and report nonrandom cytogenetic alterations associated with the tumor development. '), ('10398', 'ERBB2_RARA', '', 'ERBB2', 'RARA', '1701231', '31', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', 'Receptor', 'Transcription_Factor', '', '', 'We report: (i) that the respective position of the five genes is centromere - c-erbA-1 - G-CSF - c-erbB-2 - RAR alpha - MPO - telomere. '), ('10399', 'BCR_ABL1', '', 'BCR', 'ABL1', '12419580', '31', 'chronic myeloid leukemia', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Fluorescence in situ hybridization studies showed that the 18p rearrangement resulted from translocation of the main part of chromosome 22 long arm to 18p, including BCR-ABL1 fusion.     ///    \"The 18p abnormality resulted, thus, in loss of 18p and duplication of BCR-ABL1 in both patients. \"    ///    \"Identical abnormality of the short arm of chromosome 18 in two Philadelphia-positive chronic myelocytic leukemia patients with erythroblastic transformation, resulting in duplication of BCR-ABL1 fusion.. \"'), ('10400', 'ETO_AML1', 't(8;21)  / t(8;21) / ', 'ETO', 'AML1', '12427969', '30', 'leukemia\r\r', '', '', '', '', '', '', '', '', 'Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins.. '), ('10401', 'ETO_AML1', 't(21;8;1)(q22;q22;q32) / t(8;21)  / t(8;21)(q22;q22) / t(21;8;1)  / ', 'ETO', 'AML1', '22484534', '29', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', '', '', 'Fluorescence in situ hybridization study revealed the presence of the AML1-ETO chimeric gene on the derivative chromosome 8. '), ('10402', 'SYT_SSX1', 'p11.2;q11.2 / ', 'SYT', 'SSX1', '11850075', '28', 'synovial sarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', 'Real-time polymerase chain reaction using primer sets specific for SYT-SSX1 and SYT-SSX2 confirmed the presence of an SYT-SSX1 fusion transcript. '), ('10403', 'SYT_SSX2', 'p11.2;q11.2 / ', 'SYT', 'SSX2', '11850075', '28', 'synovial sarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', 'Real-time polymerase chain reaction using primer sets specific for SYT-SSX1 and SYT-SSX2 confirmed the presence of an SYT-SSX1 fusion transcript. '), ('10404', 'RARA_PLZF', 't(11;17)  / ', 'RARA', 'PLZF', '10381496', '28', 'acute promyelocytic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', '', '', 'Bone marrow and blood became negative in fluorescense in situ hybridization analysis and semi-quantitative polymerase chain reaction showed a profound reduction of promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion transcripts. '), ('10405', 'RARA_PML', 't(15;17)(q22;q21) / ', 'RARA', 'PML', '15717685', '28', 'acute promyelocytic leukemia;leukemia;disseminated intravascular coagulation\r\r', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', 'KB', 'Seq', 'Fluorescence in situ hybridization assay revealed 2 promyelocytic leukemia and retinoic acid receptor alpha (PML/RARA) fusion signals, and reverse transcription-polymerase chain reaction assay revealed short-form PML/RARA fusion transcript. '), ('10406', 'VTI1A_TCF7L2', '', 'VTI1A', 'TCF7L2', '24943349', '27', 'colorectal cancer;colorectal carcinoma\r\r', '', '', '', '', '', 'Transcription_Factor', 'KB', '', 'Although we did not identify a TCF7L2-VTI1A translocation, we did detect a TCF7L2 mutation in one tumor. '), ('10407', 'MET_HGF', '', 'MET', 'HGF', '24722154', '27', 'non small cell lung cancer;lung cancer\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', 'However, the deregulation of MET/HGF pathway in NSCLC harboring ALK gene rearrangement (ALK[+]), which is sensitive to dual ALK and MET inhibitor Crizotinib, has not been reported.     ///    \"We performed systematic analysis of MET/HGF expression by immunohistochemistry (IHC) and MET gene amplification by dual color, dual hapten bright field in situ hybridization in 19 ALK(+) and 73 ALK(-) NSCLC tumor tissues from those who had clinical ALK rearrangement test done at the Cleveland Clinic from August 2010 to January 2013. \"'), ('10408', 'PBX1_EWSR1', '', 'PBX1', 'EWSR1', '24487475', '26', 'myoepithelioma', 'ISH', '', '', '', '', 'Transcription_Factor', '', '', 'Fluorescence in situ hybridization for EWS gene rearrangement and reverse transcriptase polymerase chain reaction for EWSR1-POU5F1 and EWSR1-PBX1, molecular abnormalities which are found in some extrasalivary myoepitheliomas, were negative. '), ('10409', 'CD19_CD10', 't(8;13)(p11;q12) / t(8;13)  / ', 'CD19', 'CD10', '11919390', '26', 'myeloproliferative disorder\r\r', '', '', '', '', '', '', '', '', 'The lymphoblasts were CD19/CD10 dual positive. '), ('10410', 'MUM1_IRF4', 't(8;14)(q24;q32) / t(12;14)(q24;q32) / t(1;3)(q12;p12) / t(4;17)(q21;p11) / t(8;14) / t(12;14)  / t(8;12;14) / ', 'MUM1', 'IRF4', '22041376', '26', '', 'ISH', '', 'Oncogene', 'Tumor_suppressor', '', 'Transcription_Factor', '', '', 'Lymphoma cells obtained from the ascitic fluid were CD10(+), CD20(+), CD38(+), HLA-DR(+), BCL6(-), MUM1/IRF4(+), BCL2(+), and immunoglobulin ?/?(+). '), ('10411', 'POU5F1_EWSR1', '', 'POU5F1', 'EWSR1', '24487475', '26', 'myoepithelioma', 'ISH', '', '', '', '', 'Transcription_Factor', '', '', 'Fluorescence in situ hybridization for EWS gene rearrangement and reverse transcriptase polymerase chain reaction for EWSR1-POU5F1 and EWSR1-PBX1, molecular abnormalities which are found in some extrasalivary myoepitheliomas, were negative. '), ('10412', 'IGL_CCND2', 't(11;14)(q13;q32) / ', 'IGL', 'CCND2', '21504716', '26', 'B cell lymphoma;mantle cell lymphoma;lymphoma\r\r', 'ISH', '', '', '', '', '', '', '', 'Fluorescence in situ hybridization was negative for CCND1 abnormalities, but demonstrated a CCND2/IGL fusion. '), ('10413', 'BCR_ABL1', '', 'BCR', 'ABL1', '18425374', '26', '', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Together with previous findings, these data suggest that these variant translocations occur more often as a 3-break single-step process with no reciprocal ABL-BCR fusion. '), ('10414', 'IGH_CCND1', 't(11;14)(q13;q32) / t(1;12)(p21;q23) / ', 'IGH', 'CCND1', '14514791', '26', 'mantle cell lymphoma;lymphoma\r\r', '', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Fluorescence in situ hybridisation analysis using a dual colour immunoglobulin heavy chain (IgH)/CCND1 probe showed a fusion hybridisation signal on one normal chromosome 14, indicating that an insertion of the CCND1 gene into the 14q32/IgH locus had taken place. '), ('10415', 'PHF23_NUP98', 't(11;17)(p15;p13) / ', 'PHF23', 'NUP98', '27060678', '25', 'acute myeloid leukemia;myeloid leukemia;leukemia;hematologic malignancy\r\r', '', '', '', '', '', '', '', '', 'To our knowledge this is the first transcriptome analysis of human samples with NUP98-PHF23 positive AML.     ///    \"Using RNA sequencing, we determined in-frame fusion points and also analyzed the gene expression profile of NUP98-PHF23 positive AML. \"    ///    Our findings are in support of the gene expression study of NUP98-PHF23 mouse model and validate the usefulness of the mouse model in developing therapeutic strategies for the treatment of subsets of AML.     ///    \"Gene set enrichment analysis (GSEA) demonstrates that NUP98-PHF23 fusion shares gene expression signature of NUP98-HOXA9 fusion, the prototype of the NUP98-associated fusions, as well as the signature of leukemic stem cells. \"    ///    NUP98-PHF23 fusion is recurrent in acute myeloid leukemia and shares gene expression signature of leukemic stem cells.. '), ('10416', 'CALM_AF10', 't(10;11)(p13;q14-21) / ', 'CALM', 'AF10', '11417476', '25', '', '', '', '', '', '', '', '', '', 'Fluorescence in situ hybridisation and reverse transcriptase polymerase chain reaction were used to confirm the presence of a CALM-AF10 fusion.     ///    \"Here we describe for the first time, the occurrence of a CALM-AF10 fusion in a case of acute megakaryoblastic leukaemia. \"    ///    Identification and molecular characterisation of a CALM-AF10 fusion in acute megakaryoblastic leukaemia.. '), ('10417', 'P300_NUT', 't(15;19) / ', 'P300', 'NUT', '25512383', '25', '', '', '', '', '', '', '', '', '', 'This gene transcription function was repressed by either expression of a dominant negative inhibitor of the p300-NUT interaction or treatment with (+)-JQ1, which dissociates BRD4 from the LacO chromatin locus. '), ('10418', 'MMSET_FGFR3', '', 'MMSET', 'FGFR3', '16461302', '24', 'multiple myeloma\r\r', 'ISH', 'Kinase', '', '', '', '', '', '', 'Supervised analysis identified 166 genes with significantly different expression among the cell lines harboring MMSET/FGFR3 (4p16), MAF (16q) and CCND1 (11q13) rearrangements. '), ('10419', 'NR4A3_EWSR1', '', 'NR4A3', 'EWSR1', '23588370', '24', 'chondrosarcoma;sarcoma\r\r', 'ISH', '', '', '', 'Receptor', 'Transcription_Factor', 'KB', '', 'We propose to classify tumors with the appropriate phenotype and molecularly confirmed NR4A3/EWSR1 rearrangements as myxochondroid sarcoma, either osseous or extraskeletal variants.. '), ('10420', 'BCR_ABL1', 't(9;22) / t(9;22)  / ', 'BCR', 'ABL1', '18156729', '23', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Fluorescence in situ hybridization analysis showed two ABL-BCR fusion signals on the derivative chromosome 9 and one BCR-ABL fusion signal on the derivative chromosome 22. '), ('10421', 'TEL_AML1', 'del(14)(q21) / ', 'TEL', 'AML1', '16080963', '23', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', '', '', 'Fluorescence in situ hybridization performed using the probes TEL/AML1 and immunoglobulin heavy chain (IGH) showed no fusion involving the TEL and AML1 genes and only a single IGH signal in 20% of the interphase cells analyzed.. '), ('10422', 'FPS_FES', 'del(5q) / ', 'FPS', 'FES', '2209086', '23', 'familial polyposis coli', 'ISH', 'Kinase', '', '', '', '', '', '', 'This FES/FPS-related gene, named FER, lacks the transmembrane and extracellular domains which characterize tyrosine kinases with receptor function. '), ('10423', 'BCR_ABL1', 't(3;5)  / ', 'BCR', 'ABL1', '20085582', '23', '', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', ' We identified four patients who presented with BCR-ABL1 negative myeloproliferative neoplasms and cytogenetically visible abnormalities of chromosome band 5q31-35. '), ('10424', 'NF2_ERM', '18p11.3 / ', 'NF2', 'ERM', '12115567', '23', 'breast cancer;lung cancer;ductal carcinoma\r\r', '', '', '', '', '', '', '', '', ' The differentially expressed in adenocarcinoma of the lung (DAL-1) gene, which shares significant homology with members of the 4.1/ezrin/radixin/moesin/neurofibromatosis 2 (ERM/NF2) protein family, has previously been shown to suppress growth in lung cancer cell lines. '), ('10425', 'MUM1_IRF4', 't(14;18)(q32;q21) / ', 'MUM1', 'IRF4', '18925696', '23', 'follicular lymphoma;B cell lymphoma;lymphoma\r\r', 'ISH', '', 'Oncogene', 'Tumor_suppressor', '', 'Transcription_Factor', '', '', 'In 53 patients with diffuse large B-cell lymphoma and 20 patients with follicular lymphoma grade 3 with >75% follicular growth pattern the following was performed: 1) determination of protein expression of BCL6, CD10, MUM1/IRF4, CD138, and BCL2 by immunohistochemistry. '), ('10426', 'AE3_AE1', '', 'AE3', 'AE1', '25543160', '23', '', 'ISH', '', '', '', '', '', '', '', 'The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majority of tumor cells marked also with p63 and p40. '), ('10427', 'COL5A2_COL3A1', 'del(2q32)  / ', 'COL5A2', 'COL3A1', '20034071', '23', 'ectodermal dysplasia', '', '', '', '', '', '', '', '', 'The deletion leads to hemizygosity for the HOXD cluster and its regulatory elements, COL3A1/COL5A2, GTF3C3, CASP8, CASP10, and SABT2 could perhaps interfere with long range control of DLX1 and DLX2 expression. '), ('10428', 'LAT_CD61', 't(8;21)  / t(8;21) / ', 'LAT', 'CD61', '17170724', '23', 'leukemia;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', 'CD68/KP1 was the most commonly expressed marker (100%), followed by myeloperoxidase (83.6%), CD117 (80.4%), CD99 (54.3%), CD68/PG-M1 (51%), CD34 (43.4%), terminal-deoxy-nucleotidyl-transferase (31.5%), CD56 (13%), CD61/linker for activation of T cells (2.2%), CD30 (2.2%) and CD4 (1.1%). '), ('10429', 'SETBP1_NUP98', 't(11;18)(p15;q12) / ', 'SETBP1', 'NUP98', '17233820', '22', 'T ALL\r\r', '', '', '', '', '', '', 'KB', '', 'Nested polymerase chain reaction did not amplify the reciprocal SETBP1/NUP98, suggesting that NUP98/SETBP1 transcript is pathogenetically important. '), ('10430', 'RARA_PML', 'p15;q21 / t(10;17)(p15;q21) / ', 'RARA', 'PML', '17175384', '22', 'leukemia\r\r', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', 'KB', 'Seq', 'Fluorescence in situ hybridization with the LSI PML/RARA dual-color probe showed the breakpoint to be distal to the RARA locus. '), ('10431', 'MALT1_API2', '', 'MALT1', 'API2', '15363040', '22', 'MALT lymphoma;B cell lymphoma;lymphoma\r\r', '', '', '', '', '', '', '', '', 'Therefore, detection of API2-MALT1 fusion transcripts is useful for evaluating the prognosis and clinical behavior of the disease..     ///    \"Expression of API2-MALT1 fusion transcripts was detected by reverse transcription-polymerase chain reaction analysis using formalin-fixed, paraffin-embedded tissue. \"    ///    Intestinal MALT lymphomas with API2-MALT1 expression have distinctive forms of infiltration compared with those without translocation. '), ('10432', 'RARA_PML', 't(15;17)  / ', 'RARA', 'PML', '17934255', '21', 'acute promyelocytic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', 'KB', 'Seq', 'Molecular analysis by reverse transcription polymerase chain reaction using primers for different PML-RARA junctions showed bands with different sizes compared with those generated from the three classical breakpoints, namely bcr1, bcr2 and bcr3.     ///    Identification of atypical PML-RARA breakpoint in a patient with acute promyelocytic leukemia.. '), ('10433', 'TFE3_ASPL', 'p11;q25 / ', 'TFE3', 'ASPL', '18176180', '21', 'alveolar soft part sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'The specificity of the affinity purified antibodies for the synthetic peptides and recombinant expressed ASPL-TFE3 type 1 and ASPL-TFE3 type 2 proteins was evaluated by enzyme-linked immunosorbent assay and was highly fusion type specific.     ///    \"In this study, polyclonal antibodies were generated to 25 mer peptides encompassing the junctional regions of ASPL-TFE3 type 1 and ASPL-TFE3 type 2. \"    ///    Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma.. '), ('10434', 'MSH2_MLH1', '', 'MSH2', 'MLH1', '16003840', '21', 'hereditary nonpolyposis colorectal cancer', '', '', '', '', '', '', '', '', 'These results showed that MSH2/MLH1 rearrangements in Spanish patients at risk for HNPCC seem to be a less frequent mutational event than in other populations.. '), ('10435', 'FLI1_EWSR1', 't(11;22)  / t(21;22)  / ', 'FLI1', 'EWSR1', '22703924', '21', 'ewing sarcoma;neuroectodermal tumor;neuroblastoma;sarcoma\r\r', 'ISH', '', '', '', '', '', '', 'Seq', 'Fluorescence in situ hybridization analysis revealed the presence of EWSR1/FLI1 translocation in both histologic distinct components.     ///    Extraosseous Ewing sarcoma with foci of neuroblastoma-like differentiation associated with EWSR1(Ewing sarcoma breakpoint region 1)/FLI1 translocation without prior chemotherapy.. '), ('10436', 'EML4_ALK', '', 'EML4', 'ALK', '22964709', '21', 'non small cell lung cancer;lung cancer\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Moreover, 2 patients with concurrent EML4-ALK and EGFR mutations had superior PFS after EGFR-TKI compared to patients with single EML4-ALK rearrangement.     ///    Patients with stage IV NSCLC were screened for EML4-ALK rearrangement and EGFR mutations at the Peking University Cancer Hospital.     ///    EML4-ALK rearrangement and its clinical significance in Chinese patients with advanced non-small cell lung cancer..     ///    Response to EGFR-tyrosine kinase inhibitor (TKI) was similar between patients with EML4-ALK rearrangement and EGFR mutation (33.3 vs.     ///    EML4-ALK was identified using fluorescent in situ hybridization and confirmed by immunohistochemistry.     ///    Patients with EML4-ALK were more likely to present the EGFR wild type (WT.     ///    Patients with EML4-ALK conferred similar objective response rates after EGFR-TKI although inferior PFS compared to those with EGFR mutation.     ///    Coexistence of EML4-ALK and EGFR mutation might represent a separate NSCLC genotype..     ///    The incidence of EML4-ALK was 9.7% (11/113).     ///    Patients with EML4-ALK were more likely to present the EGFR wild type (WT; p = 0.033).'), ('10437', 'EML4_ALK', '', 'EML4', 'ALK', '19667264', '21', 'non small cell lung cancer;lung cancer;adenocarcinoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'EML4-ALK was identified by using fluorescent in situ hybridization for ALK rearrangements and was confirmed by immunohistochemistry for ALK expression.     ///    EML4-ALK defines a molecular subset of NSCLC with distinct clinical characteristics.     ///    \"Of 141 tumors screened, 19 (13%) were EML4-ALK mutant, 31 (22%) were EGFR mutant, and 91 (65%) were wild type (WT/WT) for both ALK and EGFR. \"    ///    \"To aid in identification and treatment of these patients, we examined the clinical characteristics and treatment outcomes of patients who had NSCLC with and without EML4-ALK. \"    ///    \"Among patients with metastatic disease, EML4-ALK positivity was associated with resistance to EGFR tyrosine kinase inhibitors (TKIs). \"    ///    \"Compared with the EGFR mutant and WT/WT cohorts, patients with EML4-ALK mutant tumors were significantly younger (P < .001 and P = .005) and were more likely to be men (P = .036 and P = .039). \"    ///    Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK..     ///    Patients in the EML4-ALK cohort and the WT/WT cohort showed similar response rates to platinum-based combination chemotherapy and no difference in overall survival.     ///    \"Eighteen of the 19 EML4-ALK tumors were adenocarcinomas, predominantly the signet ring cell subtype. \"    ///     The EML4-ALK fusion oncogene represents a novel molecular target in a small subset of non-small-cell lung cancers (NSCLC). '), ('10438', 'TACC3_FGFR3', '', 'TACC3', 'FGFR3', '25294908', '21', 'non small cell lung cancer;lung cancer;adenocarcinoma\r\r', '', 'Kinase', '', '', '', '', '', '', 'FGFR3-TACC3 rearrangements occur in a subset of patients with lung adenocarcinoma.     ///    Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma.    ///    \"Two additional patients harboring FGFR3-TACC3 were identified by screening our entire cohort (overall prevalence, 0.5%). \"    ///    Expression of FGFR3-TACC3 led to IL3 independent growth in Ba/F3 cells.     ///    We identified a FGFR3-TACC3 fusion event in one of 24 patients from this subset using targeted NGS.     ///    Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma.. '), ('10439', 'RUNX1_ETV6', '', 'RUNX1', 'ETV6', '16552772', '21', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', 'Fluorescence in situ hybridization revealed that eight of the nine B-cell precursor (BCP) cases and none of the three T-cell ALL cases had an ETV6/RUNX1 rearrangement.     ///    Near-tetraploidy in childhood B-cell precursor acute lymphoblastic leukemia is a highly specific feature of ETV6/RUNX1-positive leukemic cases.. '), ('10440', 'SYT_SSX', 'p11.2;q11.2 / ', 'SYT', 'SSX', '12414507', '21', 'synovial sarcoma;fibrous histiocytoma;sarcoma;histiocytoma\r\r', 'ISH', '', '', '', '', '', '', '', 'A tissue microarray containing 37 synovial sarcoma samples verified to bear the SYT-SSX fusion was constructed for complementary analyses.     ///    \"The chimeric SYT-SSX products are thought to function as transcriptional proteins that deregulate gene expression, thereby providing a putative oncogenic stimulus. \"'), ('10441', 'PDGFRA_FIP1L1', '', 'PDGFRA', 'FIP1L1', '26457233', '21', 'myeloid leukemia;sarcoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Refractory myeloid sarcoma with a FIP1L1-PDGFRA rearrangement detected by clinical high throughput somatic sequencing..     ///    Our clinical NGS assay detected an unanticipated FIP1L1-PDGFRA rearrangement in his tumor. '), ('10442', 'RET_PTC3', '', 'RET', 'PTC3', '20012784', '21', 'papillary carcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Screening for BRAF, RET, KRAS, NRAS, and HRAS mutations, as well as RET-PTC1 and RET-PTC3 rearrangements, was performed on paraffin-embedded material from 17 of these dominant nodules. '), ('10443', 'PHF1_JAZF1', '', 'PHF1', 'JAZF1', '23629446', '21', 'sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', 'JAZF1 rearrangement in a mesenchymal tumor of nonendometrial stromal origin: report of an unusual ossifying sarcoma of the heart demonstrating JAZF1/PHF1 fusion..     ///    \"The unique morphology and the presence of a JAZF1/PHF1 rearrangement suggest that this distinctive ossifying sarcoma is not part of a currently established diagnostic entity, representing instead a novel primary cardiac sarcoma. \"    ///    We report a distinct primary cardiac ossifying sarcoma that harbored a JAZF1/PHF1 fusion.     ///    \"Fluorescence in situ hybridization using a dual-color, single-fusion probe set identified the JAZF1/PHF1 fusion. \"'), ('10444', 'CLTC_ALK', '', 'CLTC', 'ALK', '18458503', '21', 'B cell lymphoma;lymphoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', '', '[Cytomorphology and molecular characterization of CLTC-ALK rearrangement in 2 cases of ALK-positive diffuse large B-cell lymphoma with extensive bone marrow involvement]..     ///    Fluorescence in situ hybridization and molecular studies on the bone marrow aspirate specimens led to the detection of a clathrin (CLTC)/ALK rearrangement. '), ('10445', 'PPARG_PAX8', '', 'PPARG', 'PAX8', '25047205', '21', 'thyroid nodule\r\r', '', '', '', '', 'Receptor', 'Transcription_Factor', 'KB', 'Seq', 'The rule out (gene expression classifier) approach requires confirmation by independent studies, whereas the rule in approach (detection of BRAF, NRAS, HRAS, and KRAS and PAX8/PPARG- and RET/PTC rearrangements) has been investigated by several groups with overall reproducible results. '), ('10446', 'RARA_PML', '', 'RARA', 'PML', '24189654', '21', 'acute myeloid leukemia;myeloid leukemia;leukemia;melanoma\r\r', '', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', 'KB', 'Seq', 'In clinical samples with ? 10% tumor cells, UW-OncoPlex correctly identified 129 of 130 known mutations [sensitivity 99.2%, (95% CI, 95.8%-99.9%)], including single nucleotide variants, small insertions and deletions, internal tandem duplications, gene copy number gains and amplifications, gene copy losses, chromosomal gains and losses, and actionable genomic rearrangements, including ALK-EML4, ROS1, PML-RARA, and BCR-ABL. '), ('10447', 'EML4_ALK', '', 'EML4', 'ALK', '26327925', '21', 'non small cell lung cancer;lung cancer\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Fluorescence in situ hybridization is used as the diagnostic test for detecting an EML4-ALK rearrangement. '), ('10448', 'MET_ALK', '', 'MET', 'ALK', '24192513', '21', 'non small cell lung cancer', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', 'Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement.. '), ('10449', 'P300_CREBBP', 't(15;19) / ', 'P300', 'CREBBP', '25512383', '21', '', '', '', '', '', '', 'Transcription_Factor', '', '', 'Using this system, we demonstrated that the NUT protein tethered to the LacO locus recruits p300/CREB-binding protein (CBP), induces histone hyperacetylation, and enriches BRD4 to the transgene array chromatin foci. '), ('10450', 'NUP98_HOXA9', 't(11;17)(p15;p13) / ', 'NUP98', 'HOXA9', '27060678', '21', 'acute myeloid leukemia;myeloid leukemia;leukemia;hematologic malignancy\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', 'Seq', 'Gene set enrichment analysis (GSEA) demonstrates that NUP98-PHF23 fusion shares gene expression signature of NUP98-HOXA9 fusion, the prototype of the NUP98-associated fusions, as well as the signature of leukemic stem cells. '), ('10451', 'EML4_ALK', '', 'EML4', 'ALK', '24189654', '21', 'acute myeloid leukemia;myeloid leukemia;leukemia;melanoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'In clinical samples with ? 10% tumor cells, UW-OncoPlex correctly identified 129 of 130 known mutations [sensitivity 99.2%, (95% CI, 95.8%-99.9%)], including single nucleotide variants, small insertions and deletions, internal tandem duplications, gene copy number gains and amplifications, gene copy losses, chromosomal gains and losses, and actionable genomic rearrangements, including ALK-EML4, ROS1, PML-RARA, and BCR-ABL. '), ('10452', 'PLAG1_HMGA2', '', 'PLAG1', 'HMGA2', '25439740', '21', 'pleomorphic adenoma;adenocarcinoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Interestingly, rearrangements of PLAG1/HMGA2 were identified in most hypocellular PAs but only in a small subset of cellular PAs. '), ('10453', 'TCL_CGD', '', 'TCL', 'CGD', '25197420', '21', 'T cell lymphoma;lymphoma\r\r', 'ISH', '', '', '', '', '', '', '', 'CGD-TCL was diagnosed by histopathology, immunophenotype, in situ hybridization and analysis of TCR? genes rearrangement.     ///    \" Primary cutaneous ??-T-cell lymphoma (CGD-TCL) is a distinct disease entity which is an extremely rare neoplasm with poor prognosis, characterized by the ?/? T-cell receptor expression on atypical lymphocytes. \"    ///    Primary cutaneous ??-T-cell lymphoma (CGD-TCL) with unilateral lower extremity swelling as first-onset symptom: a rare case report..     ///    \"To our knowledge, this case is the first report of CGD-TCL with unilateral lower extremity swelling as the first-onset symptom. \"    ///    \"If patient is presented the first symptoms such as swelling of extremities, especially when ulceration appears, it is of great significance to be considerate about the possibility of CGD-TCL. \"'), ('10454', 'BCR_ABL1', '', 'BCR', 'ABL1', '11810275', '21', 'chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', ' Leukemic cells of a patient diagnosed with chronic myeloid leukemia (CML) showed a complex BCR-ABL1 rearrangement hidden within a normal appearing karyotype. '), ('10455', 'RET_PTC', '', 'RET', 'PTC', '15472223', '21', 'follicular adenoma;goitre', '', 'Kinase', 'Oncogene', '', '', '', '', '', '60 of these samples were also examined for RET/PTC rearrangements.     ///    Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma..     ///    These results indicate that BRAF mutation and RET/PTC rearrangements are molecular markers of PTC that can be applied to FNA in adjunct to traditional cytology..     ///    The identification of BRAF mutation and RET/PTC refined the diagnosis of PTC in five of 15 samples that were considered either indeterminate or insufficient at cytology.     ///    RET/PTC was found in 18% of the PTC cases. '), ('10456', 'INT2_HST', '', 'INT2', 'HST', '2078507', '21', 'breast carcinoma\r\r', '', '', '', '', '', '', '', '', 'These units do not show any important rearrangement over rather large distances around the HST/INT2 and BCL1 loci.. '), ('10457', 'MLL_ENL', 't(11;19)  / ', 'MLL', 'ENL', '11313972', '21', 'leukemia\r\r', '', '', '', '', '', '', '', '', 'ENL contributes a crucial protein-protein interaction domain to the resulting oncoprotein MLL-ENL.     ///    The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3..     ///    The recruitment of a repressive function by ENL opens up a new insight into a possible mechanism of leukemogenesis by the fusion protein MLL-ENL.. '), ('10458', 'BCL2_IGH', '', 'BCL2', 'IGH', '15101720', '21', 'follicular lymphoma;lymphoma\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Correlation between histological subtype and type of bcl-2/IgH rearrangement in follicular lymphomas..     ///    \"In 30 cases, we also obtained consecutive peripheral blood samples to search for the presence of bcl-2/IgH rearrangement. \"'), ('10459', 'RARA_PML', '', 'RARA', 'PML', '20513534', '21', 'myeloid leukemia', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', 'KB', 'Seq', 'This represents a rare case of APL with a cryptic PML-RARA rearrangement presenting as myeloid sarcoma at multiple relapses and involving multiple anatomical sites, including cardiac atrium..     ///    Unusual presentation of myeloid sarcoma in a case of acute promyelocytic leukemia with a cryptic PML-RARA rearrangement involving multiple sites including the atrium.. '), ('10460', 'RET_PTC', '', 'RET', 'PTC', '25047205', '21', 'thyroid nodule\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'The rule out (gene expression classifier) approach requires confirmation by independent studies, whereas the rule in approach (detection of BRAF, NRAS, HRAS, and KRAS and PAX8/PPARG- and RET/PTC rearrangements) has been investigated by several groups with overall reproducible results. '), ('10461', 'PDGFRA_FIP1L1', '', 'PDGFRA', 'FIP1L1', '23232855', '21', 'lymphoblastic leukemia;leukemia;sarcoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'A case of nonleukemic myeloid sarcoma with FIP1L1-PDGFRA rearrangement: an unusual presentation of a rare disease..     ///    \"To our knowledge, this is the first case of a nonleukemic myeloid sarcoma with the FIP1L1-PDGFRA rearrangement. \"    ///    Fluorescent in situ hybridization studies demonstrated that both bone marrow hematopoietic precursors and blasts of the myeloid sarcoma were positive for FIP1L1-PDGFRA rearrangement. '), ('10462', 'HPC3_ENL', 't(11;19)  / ', 'HPC3', 'ENL', '11313972', '21', 'leukemia\r\r', '', '', '', '', '', '', '', '', 'The ENL-hPc3 interaction was verified by mutual co-precipitation of the proteins from cell extracts. '), ('10463', 'RET_PTC1', '', 'RET', 'PTC1', '17199737', '20', '', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Activating mutations of the BRAF gene and all three RAS genes were detected by polymerase chain reaction-direct sequencing, and RET/PTC1 rearrangements were screened by nested reverse transcription-polymerase chain reaction.     ///    \"Twenty-eight cases (66.7%) of BRAF V600E mutation, three cases (7.1%) of RET/PTC1 rearrangement but no cases of RAS genes mutation were identified. \"'), ('10464', 'EML4_ALK', '', 'EML4', 'ALK', '24885608', '20', 'non small cell lung cancer;lung cancer\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'The discovery of the fusion gene echinodermmicro tubule associated proteinlike 4-anaplastic lymphoma kinase, EML4-ALK, in patients with non-small-cell lung cancer has led to the remarkable development of anaplastic lymphoma kinase inhibitors, such as crizotinib.    ///    \" The discovery of the fusion gene echinodermmicro tubule associated proteinlike 4-anaplastic lymphoma kinase, EML4-ALK, in patients with non-small-cell lung cancer has led to the remarkable development of anaplastic lymphoma kinase inhibitors, such as crizotinib. \"'), ('10465', 'PIK3CA_AKT1', '', 'PIK3CA', 'AKT1', '24352642', '20', 'prostate cancer\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'However, the PIK3CA/AKT pathway was mutated in 10% of our samples. '), ('10466', 'TAL1_SCL', '', 'TAL1', 'SCL', '17112790', '20', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', '', '', '', 'Transcription_Factor', '', '', ' The TAL-1/SCL and LYL-1 genes encode two closely related basic helix-loop-helix transcription factors involved in child T-acute lymphoblastic leukemia through chromosomal rearrangements and transcriptional deregulation.     ///    \"Similar to Tal-1/SCL, Lyl-1 mRNA expression occurs in the developing cardiovascular and hematopoietic systems. \"    ///    \"During ontogeny, Tal-1/SCL is required for hematopoietic cell generation, both in the yolk sac, where erythro-myeloid cells are first produced, then in the intra-embryonic compartment, where hematopoietic stem cells independently arise. \"    ///    \"In contrast, whereas Lyl-1 mRNA is expressed in yolk sac-derived endothelial and hematopoietic cells, Lyl-1Delta/beta-Gal is either absent or poorly expressed in these cell types, thus differing from Tal-1/SCL, which is highly expressed there at both mRNA and protein levels.. \"'), ('10467', 'AE3_AE1', '', 'AE3', 'AE1', '25466466', '20', '', 'ISH', '', '', '', '', '', '', '', 'Immunohistochemical staining demonstrated focal EMA, cytokeratin AE1/AE3, cytokeratin CAM 5.2, p63, CD138, and vimentin positivity. '), ('10468', 'EWSR1_ATF1', '', 'EWSR1', 'ATF1', '25543160', '19', '', 'ISH', '', '', '', '', 'Transcription_Factor', 'KB', 'Seq', 'Fluorescence in situ hybridization revealed Ewing Sarcoma Breakpoint Region 1 (EWSR1) rearrangement, and reverse-transcription polymerase chain reaction confirmed the presence of the EWSR1-Activating Transcription Factor 1 (ATF1) fusion transcript, which was subsequently sequenced.    ///    \"Fluorescence in situ hybridization revealed Ewing Sarcoma Breakpoint Region 1 (EWSR1) rearrangement, and reverse-transcription polymerase chain reaction confirmed the presence of the EWSR1-Activating Transcription Factor 1 (ATF1) fusion transcript, which was subsequently sequenced. \"'), ('10469', 'PTD_MLL', '', 'PTD', 'MLL', '17408461', '19', '', '', '', '', '', '', '', '', '', 'MLL-PTD of exon 2 to exon 6 and exon 2 to exon 8 was revealed using Southern blotting, fluorescence in situ hybridisation, and reverse transcription polymerase chain reaction/DNA sequencing.     ///    This is the first report of an in vivo animal model exhibiting the systemic involvement of childhood AML containing MLL-PTD.     ///    \"The prognostic impact and contribution to leukaemogenesis of MLL-PTD, especially in childhood cases, remain unknown. \"    ///    We have established a novel cell line containing MLL-PTD derived from an 11-year-old patient with AML and designated as KOPM-88. '), ('10470', 'EML4_ALK', '', 'EML4', 'ALK', '20009909', '18', 'non small cell lung cancer;lung cancer;adenocarcinoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'At least seven ALK gene rearrangement variants have been described involving different EML4-ALK breakpoints or rarely other non-EML4 fusion partners.    ///    At least seven ALK gene rearrangement variants have been described involving different EML4-ALK breakpoints or rarely other non-EML4 fusion partners. '), ('10471', 'CCDC28A_NUP98', 't(11;18)(p15;q12) / ', 'CCDC28A', 'NUP98', '17233820', '18', 'T ALL\r\r', '', '', '', '', '', '', '', '', ' Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. '), ('10472', 'RPL29_HIP', '3p21.1 / ', 'RPL29', 'HIP', '10516434', '18', '', 'ISH', '', '', '', '', '', '', '', 'Because many growth factors and cytokines interact with cells via heparin/heparan sulfate-proteoglycan, RPL29/HIP may play an important role on the cell surface by modulating interactions between cells and extracellular molecules.. '), ('10473', 'CD8_CD4', '', 'CD8', 'CD4', '7862157', '18', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', '', '', 'The transcripts were detected in all the CD4- CD8-, CD4+ CD8+, CD4+ CD8-, and CD4- CD8+ cell populations. '), ('10474', 'NUP98_ADD3', 't(11;18)(p15;q12) / ', 'NUP98', 'ADD3', '17233820', '18', 'T ALL\r\r', '', '', '', '', '', '', 'KB', '', ' Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. '), ('10475', 'APOC3_APOA4', 'chr11:116691770-116691711 / chr11:116703530-116703589 / chr11:59603362-59603303 / ', 'APOC3', 'APOA4', '26485402', '18', '', '', '', '', '', '', '', '', '', 'Transcriptome Reveals 1400-Fold Upregulation of APOA4-APOC3 and 1100-Fold Downregulation of GIF in the Patients with Polycythemia-Induced Gastric Injury.. '), ('10476', 'P65_P50', '1p11.2 / 5p15.3 / ', 'P65', 'P50', '11423533', '18', '', 'ISH', '', '', '', '', '', '', '', 'Finally, both transient transfection analysis and gel mobility shift assay revealed that the AhRR gene is up-regulated by a p65/p50 heterodimer that binds to the NF-kappaB site when the cells has been exposed to 12-O-tetradecanoylphorbol-13-acetate, and this inducible expression was further enhanced by cotreatment of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene.. '), ('10477', 'RAP1GDS1_NUP98', 't(11;18)(p15;q12) / ', 'RAP1GDS1', 'NUP98', '17233820', '18', 'T ALL\r\r', '', '', '', '', '', '', 'KB', '', ' Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. '), ('10478', 'HMGA2_LPP', '', 'HMGA2', 'LPP', '19654500', '17', 'liposarcoma;sarcoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', 'HMGA2-LPP fusion was seen in only 1 case.    ///    HMGA2-LPP fusion was seen in only 1 case. '), ('10479', 'P13_P12', '', 'P13', 'P12', '1733849', '17', '', 'ISH', '', '', '', '', '', '', '', 'A related sequence, GNAI2L, is mapped by in situ hybridization to the short arm of chromosome 12 at p12-p13. '), ('10480', 'RUNX1_ETV6', '', 'RUNX1', 'ETV6', '18565891', '17', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', 'We screened 1,625 patients who were enrolled onto the Austrian and German ALL-Berlin-Frankfurt-M?nster (ALL-BFM) trials 86, 90, 95, and 2000 with ETV6/RUNX1-specific fluorescent in situ hybridization probes, and we identified 29 patient cases (2%) who had an iAMP21. '), ('10481', 'SOCS5_ALK', '', 'SOCS5', 'ALK', '25567908', '17', 'adenocarcinoma', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Actionable genomic alterations with a targeted agent based on NCCN guidelines were identified in 26% [8 of 31: EGFR G719A, BRAF V600E, SOCS5-ALK, HIP1-ALK, CD74-ROS1, KIF5B-RET (n = 2), CCDC6-RET]. '), ('10482', 'BCR_ABL1', '', 'BCR', 'ABL1', '22875628', '17', 'hematologic malignancy;hematologic malignancy\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Ruxolitinib-treated Ba/F3 cells transformed to IL3 independence by ETV6-JAK2 showed reduced proliferation and survival (IC(50) = 370 nM) compared with KG1A or Ba/F3 cells transformed by BCR-ABL1, SPBN1-FLT3 and ZMYM2-FGFR1 (IC(50) > 10 ?M for all). '), ('10483', 'ROS1_CD74', '', 'ROS1', 'CD74', '25567908', '17', 'adenocarcinoma', '', 'Kinase', 'Oncogene', '', '', '', '', 'Seq', 'Actionable genomic alterations with a targeted agent based on NCCN guidelines were identified in 26% [8 of 31: EGFR G719A, BRAF V600E, SOCS5-ALK, HIP1-ALK, CD74-ROS1, KIF5B-RET (n = 2), CCDC6-RET]. '), ('10484', 'MDM2_CDK4', '', 'MDM2', 'CDK4', '24608573', '17', 'breast cancer\r\r', '', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'There was an increased frequency of CDK4/MDM2 amplifications in recurrences, as well as gains and losses of other actionable alterations. '), ('10485', 'JAK2_ETV6', '', 'JAK2', 'ETV6', '22875628', '17', 'hematologic malignancy;hematologic malignancy\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', '', 'Ruxolitinib-treated Ba/F3 cells transformed to IL3 independence by ETV6-JAK2 showed reduced proliferation and survival (IC(50) = 370 nM) compared with KG1A or Ba/F3 cells transformed by BCR-ABL1, SPBN1-FLT3 and ZMYM2-FGFR1 (IC(50) > 10 ?M for all).     ///    \"Inhibition was associated with reduced phosphorylation of ETV6-JAK2, ERK, STAT5 and AKT. \"'), ('10486', 'ZMYM2_FGFR1', '', 'ZMYM2', 'FGFR1', '22875628', '17', 'hematologic malignancy;hematologic malignancy\r\r', 'ISH', 'Kinase', '', '', '', '', 'KB', '', 'Ruxolitinib-treated Ba/F3 cells transformed to IL3 independence by ETV6-JAK2 showed reduced proliferation and survival (IC(50) = 370 nM) compared with KG1A or Ba/F3 cells transformed by BCR-ABL1, SPBN1-FLT3 and ZMYM2-FGFR1 (IC(50) > 10 ?M for all). '), ('10487', 'KRAS_EGFR', '', 'KRAS', 'EGFR', '24300132', '17', 'non small cell lung cancer;lung cancer;adenocarcinoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', 'Of the tumors with available data on the EGFR/KRAS mutation status, EGFR and KRAS mutation rates were 64% (69/108) and 5% (5/102), respectively. '), ('10488', 'HGF_MET', '', 'HGF', 'MET', '22198430', '17', 'non small cell lung cancer;squamous cell carcinoma;adenocarcinoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', ' The hepatocyte growth factor/MET pathway has been shown to cause tumor progression in several types of carcinomas. '), ('10489', 'RET_KIF5B', '', 'RET', 'KIF5B', '25567908', '17', 'adenocarcinoma', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'Actionable genomic alterations with a targeted agent based on NCCN guidelines were identified in 26% [8 of 31: EGFR G719A, BRAF V600E, SOCS5-ALK, HIP1-ALK, CD74-ROS1, KIF5B-RET (n = 2), CCDC6-RET]. '), ('10490', 'EGFR_ALK', '', 'EGFR', 'ALK', '25577516', '17', 'adenocarcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', '? EGFR/ALK testing is recommended for lung adenocarcinoma patients for EGFR/ALK-targeted TKI therapy.     ///    ? EGFR /ALK testing is restricted by limited tissue samples and cost pressures.     ///    ? pGGO and TDR are predictive factors for selecting patients for ALK/EGFR testing.. '), ('10491', 'WWTR1_CAMTA1', '', 'WWTR1', 'CAMTA1', '25353289', '17', 'angiosarcoma', 'ISH', '', '', '', '', 'Transcription_Factor', '', '', 'Thoracic epithelioid malignant vascular tumors: a clinicopathologic study of 52 cases with emphasis on pathologic grading and molecular studies of WWTR1-CAMTA1 fusions..     ///    Fluorescence in situ hybridization analysis showed CAMTA1-WWTR1 fusions in 4/7 low-grade and 23/23 intermediate-grade EHE (P<0.001). '), ('10492', 'AE3_AE1', '', 'AE3', 'AE1', '26644362', '17', 'lobular carcinoma;myoepithelioma', 'ISH', '', '', '', '', '', '', '', 'The tumor cells demonstrated immunoreactivity for cytokeratin (AE1/AE3) and glial fibrillary acidic protein, but were negative for estrogen receptor. '), ('10493', 'AIS_AAH', '', 'AIS', 'AAH', '25361983', '17', 'adenocarcinoma', '', '', '', '', '', '', '', '', 'The remaining 26 quadruple-negative tumors were significantly associated with AAH/AIS (P < 0.01) and no-growth (P < 0.01) compared with driver mutation-positive tumors, whereas EGFR mutation-positive tumors were correlated with MIA/IA (P < 0.01) and growth (P < 0.01) compared with EGFR-negative tumors. '), ('10494', 'RET_PTC1', '', 'RET', 'PTC1', '26367451', '17', 'thyroid nodule;thyroid carcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'We previously tested 15 cases by our standard 7-gene (BRAF, NRAS, HRAS, KRAS, RET/PTC1, RET/PTC3, PAX8/PPARg) mutation panel. '), ('10495', 'TGFA_EGF', '', 'TGFA', 'EGF', '1515265', '17', '', '', '', '', '', '', '', '', '', 'Because it is believed that an activation of the epidermal growth factor/transforming growth factor alpha (EGF/TGF alpha) signal pathway could be involved, we analysed the expression of epidermal growth factor receptor (EGFR) and TGF alpha with molecular-chemical, biochemical and immunohistochemical methods in 42 ovarian carcinomas, 4 ovarian metastasis, 2 other malignant ovarian tumours, and in 25 nonmalignant tissues (ovary, myometrium). '), ('10496', 'WAF1_CIP1', '', 'WAF1', 'CIP1', '20000476', '17', '', 'ISH', '', '', '', '', '', '', '', 'The role of DNA damage response proteins p53 and p21(CIP1/WAF1) in aneugenesis and clastogenesis was investigated in telomerase immortalized diploid human fibroblasts using siRNA suppression of p53 and p21(CIP1/WAF1).     ///    Micronuclei were predominantly of clastogenic origin in control cells regardless of p53 or p21(CIP1/WAF1) expression.     ///    \"Furthermore, our current results support this role for p21(CIP1/WAF1) since suppression of p21(CIP1/WAF1) caused a decrease in aneuploidy induced by arsenite, suggesting that p21(CIP1/WAF1) plays a role in mitotic exit.. \"    ///    Suppression of p21(CIP1/WAF1) like p53 suppression decreased the fraction of MN with centromeric DNA. '), ('10497', 'RET_PTC3', '', 'RET', 'PTC3', '26367451', '17', 'thyroid nodule;thyroid carcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'We previously tested 15 cases by our standard 7-gene (BRAF, NRAS, HRAS, KRAS, RET/PTC1, RET/PTC3, PAX8/PPARg) mutation panel. '), ('10498', 'HIP1_ALK', '', 'HIP1', 'ALK', '25567908', '17', 'adenocarcinoma', '', 'Kinase', 'Oncogene', '', '', '', 'KB', '', 'Actionable genomic alterations with a targeted agent based on NCCN guidelines were identified in 26% [8 of 31: EGFR G719A, BRAF V600E, SOCS5-ALK, HIP1-ALK, CD74-ROS1, KIF5B-RET (n = 2), CCDC6-RET]. '), ('10499', 'RET_CCDC6', '', 'RET', 'CCDC6', '25567908', '17', 'adenocarcinoma', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Actionable genomic alterations with a targeted agent based on NCCN guidelines were identified in 26% [8 of 31: EGFR G719A, BRAF V600E, SOCS5-ALK, HIP1-ALK, CD74-ROS1, KIF5B-RET (n = 2), CCDC6-RET]. '), ('10500', 'CD43_CD20', '', 'CD43', 'CD20', '1928555', '17', 'hairy cell leukemia;lymphoma', '', '', '', '', '', '', '', '', 'CD43 was reactive with 12 of 74 B-cell lymphomas, and CD20/CD43 coexpression was seen in 11 of these cases. '), ('10501', 'ETO_AML1', '', 'ETO', 'AML1', '19194200', '16', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', '', '', 'Within 14 acute myeloblastic leukemia patients, we confirmed 2 cases with FLT3-internal tandem duplication+, 1 patient with AML1-ETO, and only 1 case carrying a PML-RARalpha rearrangement. '), ('10502', 'EML4_ALK', '', 'EML4', 'ALK', '18320074', '16', 'non small cell lung cancer;lung cancer;adenocarcinoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Because the EML4-ALK fusion was only shown by a reverse transcription-polymerase chain reaction approach, we developed fluorescent in situ hybridization assays to interrogate more than 600 NSCLCs using break-apart probes for EML4 and ALK.     ///    \"We also observed that, in most cases in which an EML4/ALK alteration is detected, not all of the tumor cells harbor the lesion. \"    ///    We found that EML4-ALK fusions occur in less than 3% of NSCLC samples and that EML4 and/or ALK amplifications also occur.     ///    EML4-ALK fusion lung cancer: a rare acquired event.. '), ('10503', 'NTRK3_ETV6', '', 'NTRK3', 'ETV6', '24327398', '16', 'thyloid cancer\r\r', '', 'Kinase', '', '', '', '', 'KB', 'Seq', 'ETV6-NTRK3 is a common chromosomal rearrangement in radiation-associated thyroid cancer..     ///    \"Moreover, ETV6-NTRK3 rearrangement can be directly induced in thyroid cells by ionizing radiation in vitro and, thus, may represent a novel mechanism of radiation-induced carcinogenesis.. \"    ///    \"The prevalence of ETV6-NTRK3 rearrangement in post-Chernobyl PTCs was associated with increasing (131) I dose, albeit at borderline significance (P?=?.126). \"    ///    The authors report the occurrence of ETV6-NTRK3 rearrangements in thyroid cancer and demonstrate that this rearrangement is significantly more common in tumors associated with exposure to (131) I and has a borderline significant dose response.     ///    \"In vitro exposure of human thyroid cells to 1 gray of (131) I and ?-radiation resulted in the formation of ETV6-NTRK3 rearrangement at a rate of 7.9????10(-6) cells and 3.0????10(-6) cells, respectively. \"    ///    \"The group of rearrangement-positive PTCs (ETV6-NTRK3, RET/PTC, PAX8-PPAR?) was associated with significantly higher dose response compared with the group of PTCs with point mutations (BRAF, RAS. \"'), ('10504', 'ROS1_CD74', '', 'ROS1', 'CD74', '23788756', '16', 'adenocarcinoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', 'Seq', 'CD74-ROS1 fusions were identified in two patients using reverse transcriptase-polymerase chain reaction. '), ('10505', 'RET_PTC', '', 'RET', 'PTC', '24327398', '16', 'thyloid cancer\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'The group of rearrangement-positive PTCs (ETV6-NTRK3, RET/PTC, PAX8-PPAR?) was associated with significantly higher dose response compared with the group of PTCs with point mutations (BRAF, RAS. '), ('10506', 'BCR_ABL1', '', 'BCR', 'ABL1', '25928096', '16', 'chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'Next generation sequencing (NGS) of amplicons larger than 1000?bp simplified and accelerated a process of characterization of patient-specific BCR-ABL1 genomic fusions.     ///    \" In chronic myeloid leukemia, the identification of individual BCR-ABL1 fusions is required for the development of personalized medicine approach for minimal residual disease monitoring at the DNA level. \"    ///    Characterization of 46 patient-specific BCR-ABL1 fusions and detection of SNPs upstream and downstream the breakpoints in chronic myeloid leukemia using next generation sequencing.. '), ('10507', 'SSX1_SS18', '', 'SSX1', 'SS18', '22055401', '16', 'synovial sarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', 'KB', '', 'Reverse transcriptase polymerase chain reaction analysis revealed SS18-SSX1 transcripts in both cases. '), ('10508', 'EWS_ERG', '', 'EWS', 'ERG', '20308673', '16', 'neuroectodermal tumor;ewing sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Results After exclusion of noninformative patients, 565 patients were entered into the prognostic factor analysis comparing type 1 (n = 296), type 2 (n = 133), nontype 1/nontype 2 EWS-FLI1 (n = 91) and EWS-ERG fusions (n = 45). '), ('10509', 'TNNT2_RXRG', '', 'TNNT2', 'RXRG', '11685458', '16', '', 'ISH', '', '', '', 'Receptor', '', '', '', 'Furthermore, comparative mapping analysis of the RXRG-TNNT2 chromosomal segment that is conserved on human and mouse Chr 1 indicates that it is divided into four segments in the chicken, each of which maps to a different chromosome.. '), ('10510', 'P80_ALK', '', 'P80', 'ALK', '26603857', '16', 'non small cell lung cancer;squamous cell carcinoma;lung cancer;adenocarcinoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', 'ALK rearrangement was searched because of the never-smoker status of the patient and resulted in strong positive fluorescent in situ hybridization test and ALK/p80 immunohistochemistry. '), ('10511', 'ROS1_ALK', '', 'ROS1', 'ALK', '23788756', '16', 'adenocarcinoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', 'The PFS to EGFR-tyrosine kinase inhibitors in patients harboring ROS1 rearrangement was shorter than those without ROS1/ALK rearrangement (2.5 versus 7.8 months.     ///    P = 0.008) to pemetrexed than those without ROS1/ALK rearrangement. '), ('10512', 'PPP2R2A_CHEK2', 't(8;22)(p21;q12) / t(8;22)  / ', 'PPP2R2A', 'CHEK2', '16790090', '15', 'germ cell tumor', 'ISH', 'Kinase', '', 'Tumor_suppressor', '', '', '', '', 'None of the three detected PPP2R2A/CHEK2 fusion transcripts resulted in an in-frame PPP2R2A/CHEK2 chimerical open reading frame. '), ('10513', 'ETV6_NTRK3', '', 'ETV6', 'NTRK3', '25674280', '15', 'acinic cell carcinoma;adenocarcinoma\r\r', '', 'Kinase', '', '', '', '', 'KB', 'Seq', 'Here we report a case of MASC with high-grade transformation and cervical lymph node metastases confirmed with ETV6-NTRK3 translocation arising in the hard palate of a 41 year-old adult.    ///    Here we report a case of MASC with high-grade transformation and cervical lymph node metastases confirmed with ETV6-NTRK3 translocation arising in the hard palate of a 41 year-old adult.     ///    This is the first case with high grade histology that arise from minor salivary gland and it emphasizes the importance of molecular screening of salivary gland tumor with high-grade histology for ETV6-NTRK3 translocation.     ///    \"This tumor shares histologic features, immunohistochemical profile, and a highly specific genetic translocation, ETV6-NTRK3, with secretory carcinoma of breast. \"'), ('10514', 'TMPRSS2_ERG', '', 'TMPRSS2', 'ERG', '25791755', '15', 'prostate cancer\r\r', '', '', '', '', '', '', 'KB', 'Seq', 'New recurrent alterations have been identified in PCa (e.g., TMPRSS2-ERG translocation, SPOP and CHD1 mutations, and chromoplexy), and many previous ones in well-established pathways have been validated (e.g., androgen receptor overexpression and mutations. '), ('10515', 'P65_P50', '', 'P65', 'P50', '12588890', '15', '', 'ISH', '', '', '', '', '', '', '', 'Electrophoretic mobility shift assay demonstrated nuclear translocation of NF-kappaB, and the p65/p50 subunits were activated. '), ('10516', 'EML4_ALK', '', 'EML4', 'ALK', '23900599', '15', 'pulmonary cancer', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'epidermal growth factor receptor (EGFR) mutations and EML4-ALK translocations and will certainly lead to a variety of novel predictive markers not only for pulmonary adenocarcinoma but also for other pulmonary neoplasms. '), ('10517', 'POP_GAPDH', '', 'POP', 'GAPDH', '23348613', '15', 'neuroblastoma\r\r', '', '', '', '', '', '', '', '', 'To study the functional relevance of prolyl oligopeptidase-glyceraldehyde-3-phosphate dehydrogenase interactions, we investigated whether this interaction was involved in cytosine arabinoside-induced glyceraldehyde-3-phosphate dehydrogenase nuclear translocation and cell death. '), ('10518', 'TPP1_POT1', '', 'TPP1', 'POT1', '20094033', '15', '', '', '', '', '', '', '', '', '', 'POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation..     ///    \"In addition, POT1-TPP1 increased the translocation efficiency. \"    ///    \"To understand the mechanism of increased processivity, we measured the effect of POT1-TPP1 on individual steps in the telomerase reaction cycle. \"    ///    \"POT1-TPP1 increased processivity even when substoichiometric relative to the DNA, providing evidence for a recruitment function. \"    ///    \"Under conditions where telomerase was actively synthesizing DNA, POT1-TPP1 bound to the primer decreased primer dissociation rate. \"    ///    These results support a model in which POT1-TPP1 enhances telomerase processivity in a manner markedly different from the sliding clamps used by DNA polymerases..     ///    \"The POT1-TPP1 effect is specific, as another single-stranded DNA-binding protein, gp32, cannot substitute. \"'), ('10519', 'PSA_NCAM', '', 'PSA', 'NCAM', '11311794', '15', '', '', '', '', '', '', '', '', '', 'In contrast, PSA-NCAM surface translocation was inhibited reversibly by cooling the cultures at 20 degrees C, a procedure which blocks constitutive secretion and which resulted in accumulation of PSA-NCAM in the cytoplasm of oxytocinergic and non-oxytocinergic neurons.'), ('10520', 'EML4_ALK', '', 'EML4', 'ALK', '24423920', '15', 'breast carcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', '(4) no EGFR, Kras mutations or EML4-ALK translocations were found, but PI3K and Braf mutations were observed in 26% of cases.     ///    \"Tissue sections of 138 TNBCs were used (1) to compare EGFR amplification and expression by silver in situ hybridisation (SISH) to qPCR and immunohistochemistry (IHC) and (2) to search for EGFR mutations, along with Kras, PI3K, Braf and HER-2 mutations and echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) translocation. \"'), ('10521', 'IGH_BCL2', '', 'IGH', 'BCL2', '25176983', '15', 'anaplastic large cell lymphoma;follicular lymphoma;mantle cell lymphoma;lymphoma\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Some of these are clonal proliferations that carry many of the molecular hallmarks of their malignant counterparts, such as BCL2/IGH and CCND1/IGH translocations associated with the in situ forms of follicular lymphoma and mantle cell lymphoma, respectively. '), ('10522', 'EWSR1_CREB3L1', '', 'EWSR1', 'CREB3L1', '25990776', '15', 'fibrosarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', ' Sclerosing epithelioid fibrosarcoma (SEF) is a rare fibrosarcoma variant with specific histomorphology and consistent translocation (EWSR1-CREB3L1/2). '), ('10523', 'MYC_IGH', '', 'MYC', 'IGH', '19202055', '15', '', '', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'In addition, JP8Bdel enhanced c-myc/IgH translocations. '), ('10524', 'SYK_ITK', '', 'SYK', 'ITK', '18401419', '15', 'peripheral T cell lymphoma', 'ISH', 'Kinase', 'Oncogene', '', '', '', '', '', 'The recent finding of SYK/ITK translocations in rare PTCLs led us to examine the expression of Syk PTK in 141 PTCLs.     ///    Fluorescence in situ hybridization showed no SYK/ITK translocation in 86 cases. '), ('10525', 'SYT_SSX', '', 'SYT', 'SSX', '14685256', '15', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Molecular studies were performed on paraffin-embedded tissue in both cases and revealed the known characteristic t(X;18)(SYT-SSX) translocation.. '), ('10526', 'P65_NFKB1', '', 'P65', 'NFKB1', '18949064', '15', 'cataracts\r\r', '', '', '', '', '', 'Transcription_Factor', '', '', 'Fisetin inhibited UVB-induced activation and translocation of NF-kappaB/p65, which was mediated through an inhibition of the degradation and activation of IkappaB.     ///    \"Expression of NF-kappaB/P65, inhibiter kappa B (IkappaB), and mitogen activated protein kinase (MAPK) proteins were measured by western blot. \"'), ('10527', 'P65_P50', '', 'P65', 'P50', '21947415', '15', '', '', '', '', '', '', '', '', '', 'To gain insights into potential intracellular signaling pathways affected by C-peptide, we investigated nuclear translocation of nuclear factor(NF)-?B p65/p50 subunits by western blot in LPS-treated U-937 cells.     ///    These effects were accompanied by reduced NF-?B p65/p50 nuclear translocation and decreased phosphorylation of I?B-?. '), ('10528', 'IGH_CCND1', '', 'IGH', 'CCND1', '25176983', '15', 'anaplastic large cell lymphoma;follicular lymphoma;mantle cell lymphoma;lymphoma\r\r', '', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Some of these are clonal proliferations that carry many of the molecular hallmarks of their malignant counterparts, such as BCL2/IGH and CCND1/IGH translocations associated with the in situ forms of follicular lymphoma and mantle cell lymphoma, respectively. '), ('10529', 'MALT1_API2', '', 'MALT1', 'API2', '25381826', '15', 'MALT lymphoma', 'ISH', '', '', '', '', '', '', '', 'Two months later, pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma was confirmed by the detection of API2-MALT1 translocation in fluorescent in situ hybridization analysis. '), ('10530', 'MALT1_API2', '', 'MALT1', 'API2', '19907113', '14', 'B cell lymphoma;lymphoma\r\r', 'ISH', '', '', '', '', '', '', '', 'There was no API2-MALT1 fusion transcript in any of the eight cases examined. '), ('10531', 'BCR_ABL1', '', 'BCR', 'ABL1', '24339928', '14', 'chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'These results advance low Chibby1 expression associated with BCR-ABL1 as a component of beta catenin signaling in leukemic stem cells.     ///    \"however, it is strictly dependent upon BCR-ABL1 expression because it was not observed at the moment of major molecular response under tyrosine kinase inhibitor therapy. \"    ///    \"We investigated the impact of BCR-ABL1 on Chibby1, a beta catenin antagonist involved in cell differentiation and transformation. \"'), ('10532', 'BCL2_IGH', '', 'BCL2', 'IGH', '15118393', '13', 'non Hodgkin lymphoma', 'ISH', '', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'Polymerase-chain-reaction-based DNA analysis demonstrated a clonal IgH rearrangement in the absence of a bcl-2/IgH translocation. ');
INSERT INTO `ChimerPub_dump` VALUES ('10533', 'RET_PTC3', '', 'RET', 'PTC3', '14668719', '12', 'oxyphilic adenoma', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'RET hybrid oncogenes (7x RET/PTC1, 1x RET/PTC1L, 2x RET/PTC3, 5 uncharacterized RET/PTCx) were demonstrated in 7 of 27 HCCs, in 0 of 4 oxyphilic FTCs, in 4 of 5 oxyphilic PTCs, in 1 of 2 HCC-UTCs, and in 3 of 16 oxyphilic adenomas. '), ('10534', 'HAS2_PLAG1', '', 'HAS2', 'PLAG1', '25867764', '12', 'sarcoma\r\r', '', '', '', '', '', '', 'KB', 'Seq', 'Three novel (KIAA2026-NUDT11, CCBL1-ARL1, and AFF3-PHF1) and two previously known fusions (FUS-CREB3L2 and HAS2-PLAG1) were found and could be verified by other methods.    ///    \"Three novel (KIAA2026-NUDT11, CCBL1-ARL1, and AFF3-PHF1) and two previously known fusions (FUS-CREB3L2 and HAS2-PLAG1) were found and could be verified by other methods. \"'), ('10535', 'TAL1_SIL', '', 'TAL1', 'SIL', '19194200', '12', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', '', '', '', 'Transcription_Factor', '', '', 'None of the T-cell ALL cases were positive for either SIL-TAL1 or HOX11L2. '), ('10536', 'HIP1_ALK', '', 'HIP1', 'ALK', '24496003', '12', 'non small cell lung cancer;squamous cell carcinoma;non small cell lung cancer;small cell lung cancer\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', '', 'HIP1-ALK, a novel ALK fusion variant that responds to crizotinib..     ///    \"HIP1-ALK, a novel ALK fusion variant that responds to crizotinib.\"'), ('10537', 'TEL_AML1', '', 'TEL', 'AML1', '19194200', '12', 'acute lymphoblastic leukemia;lymphoblastic leukemia;leukemia\r\r', 'ISH', '', '', '', '', '', '', '', 'Twelve out of 65 (18.4%) precursor B-ALL tested positive for TEL-AML1 and 3 cases for BCR-ABL (4.6%). '), ('10538', 'myosin_MLCK', '', 'myosin', 'MLCK', '22583690', '12', '', '', '', '', '', '', '', '', '', 'Lastly, we took dominant negative plasmid and knockdown approaches to investigate the potential importance of the NF-?B/myosin light chain kinase (MLCK)/myosin light chain phosphorylation (pMLC) pathways in TNF-a-mediated damage. '), ('10539', 'RNF40_RNF20', '', 'RNF40', 'RNF20', '22354749', '12', 'seminoma\r\r', '', '', '', '', '', '', '', '', 'Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.. '), ('10540', 'RAC1_CDC42', '', 'RAC1', 'CDC42', '12032833', '12', '', 'ISH', '', '', '', '', '', '', '', 'PAK5 contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. '), ('10541', 'MDM2_CDK4', '', 'MDM2', 'CDK4', '20834238', '12', 'benign fibrous histiocytoma', '', 'Kinase', 'Oncogene', '', '', 'Transcription_Factor', '', '', 'It is less sensitive than MDM2/CDK4 for dedifferentiated liposarcomas diagnosis, but it appears more specific to distinguish dedifferentiated liposarcomas from other poorly differentiated sarcomas. '), ('10542', 'RET_PTC1', '', 'RET', 'PTC1', '14668719', '12', 'oxyphilic adenoma', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'RET hybrid oncogenes (7x RET/PTC1, 1x RET/PTC1L, 2x RET/PTC3, 5 uncharacterized RET/PTCx) were demonstrated in 7 of 27 HCCs, in 0 of 4 oxyphilic FTCs, in 4 of 5 oxyphilic PTCs, in 1 of 2 HCC-UTCs, and in 3 of 16 oxyphilic adenomas.     ///    \"After reverse transcription-polymerase chain reaction-based screening for RET rearrangements, the samples were tested for all known RET/PTC 1 to 11 hybrids with the use of artificially constructed chimeric sequences as controls. \"'), ('10543', 'CCBL1_ARL1', '', 'CCBL1', 'ARL1', '25867764', '12', 'sarcoma\r\r', '', '', '', '', '', '', '', '', 'Three novel (KIAA2026-NUDT11, CCBL1-ARL1, and AFF3-PHF1) and two previously known fusions (FUS-CREB3L2 and HAS2-PLAG1) were found and could be verified by other methods. '), ('10544', 'RAC_ELMO1', '', 'RAC', 'ELMO1', '25360637', '12', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', '', '', '', '', '', '', '', '', 'Taken together, these data show that inhibiting the ELMO1-RAC axis might be an alternative way to target leukemic cells. '), ('10545', 'NUDT11_KIAA2026', '', 'NUDT11', 'KIAA2026', '25867764', '12', 'sarcoma\r\r', '', '', '', '', '', '', '', '', 'Three novel (KIAA2026-NUDT11, CCBL1-ARL1, and AFF3-PHF1) and two previously known fusions (FUS-CREB3L2 and HAS2-PLAG1) were found and could be verified by other methods. '), ('10546', 'PHF1_AFF3', '', 'PHF1', 'AFF3', '25867764', '12', 'sarcoma\r\r', '', '', 'Oncogene', '', '', '', '', '', 'Three novel (KIAA2026-NUDT11, CCBL1-ARL1, and AFF3-PHF1) and two previously known fusions (FUS-CREB3L2 and HAS2-PLAG1) were found and could be verified by other methods. '), ('10547', 'EML4_ALK', '', 'EML4', 'ALK', '25582278', '10', 'lung cancer;adenocarcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'EGFR/KRAS mutations and EML4-ALK fusions were similar between GGO and solid adenocarcinomas.    ///    \"It is important that we understand GGO lesions of lung adenocarcinoma to identify molecular biomarkers including EGFR, KRAS and EML4-ALK. \"    ///    \"EGFR, KRAS and EML4-ALK mutations were detected by qPCR. \"'), ('10548', 'CAA_ACG', '', 'CAA', 'ACG', '19452221', '10', '', '', '', '', '', '', '', '', '', 'One AFLP marker tightly linked to the sex-determining locus was identified: the marker, ACG/CAA-217, amplified to the male-specific DNA fragment. '), ('10549', 'PAR1_MARK', '', 'PAR1', 'MARK', '14740210', '10', '', 'ISH', '', '', '', 'Receptor', '', '', '', ' MAK-V/Hunk is a recently identified MARK/Par-1-related mammalian protein kinase. '), ('10550', 'RB1_NF1', '', 'RB1', 'NF1', '17880527', '10', '', '', '', '', 'Tumor_suppressor', '', 'Transcription_Factor', '', '', 'Somatic down-regulation of MMR proteins in nodular-trabecular muscle-invasive UroC results in RB1/NF1 microsatellite abnormalities, correlating with higher cellular turnover and longer survival.. '), ('10551', 'VIP_PACAP', '', 'VIP', 'PACAP', '23027597', '10', '', 'ISH', '', '', '', '', '', '', '', 'PACAP acts by binding to three different receptors, that are classified by their binding affinity for PACAP and VIP (vasoactive intestinal polypeptide): PAC(1)R (PACAP-specific receptor) exclusively binds PACAP, while VPAC(1)R (VIP/PACAP receptor, subtype 1) and VPAC(2)R (VIP/PACAP receptor, subtype 2) bind both PACAP and VIP. '), ('10552', 'NCOR1_HDAC3', '', 'NCOR1', 'HDAC3', '25056306', '10', '', '', '', '', '', '', 'Transcription_Factor', '', '', 'Hypoxia caused nuclear translocation and co-localization of the Cdk9 and HDAC3/N-CoR repressor complex. '), ('10553', 'AE3_AE1', '', 'AE3', 'AE1', '7505508', '10', '', '', '', '', '', '', '', '', '', 'Epithelia from skin, gills, cornea, bile ducts, renal tubules, gastrointestinal tract, and thymus were strongly positive with AE1/AE3 and MAK-6 in striped bass, but nonepithelial tissues such as bone and muscle were negative.     ///    \"Using a strepavidin horseradish peroxidase method on paraffin-embedded tissues, the broad spectrum antibodies AE1/AE3 (Boehringer Mannheim, Indianapolis, IN) and MAK-6 (Triton Biosciences, Alameda, CA), which recognize most of the 19 human cytokeratins, and CAM 5.2 (Becton Dickinson, Mountain View, CA), which recognizes cytokeratins present in human liver, were used as primary antibodies. \"'), ('10554', 'MAP_ERK', '', 'MAP', 'ERK', '18977283', '10', '', 'ISH', '', '', '', '', '', '', '', 'Mammalian Ras and M-Ras mediate nerve growth factor-induced neuronal differentiation in rat PC12 cells by activating the ERK/MAP kinase pathway transiently and sustainedly, respectively. '), ('10555', 'PRB_P160', '', 'PRB', 'P160', '11079730', '10', 'esophageal cancer\r\r', '', '', '', '', '', '', '', '', 'pRb/p16INK4a pathway plays a critical role in esophageal tumorigenesis in the Indian population. '), ('10556', 'TPP1_POT1', '', 'TPP1', 'POT1', '20231318', '10', '', '', '', '', '', '', '', '', '', 'We now provide evidence that this POT1-TPP1 activation requires specific interactions with telomerase, rather than it being a DNA substrate-specific effect.     ///    POT1-TPP1 binding to telomeric DNA activates telomerase repeat addition processivity.     ///    \"Second, mutation of a conserved glycine, Gly100 in the TEN (telomerase essential N-terminal) domain of TERT, abolished the enhancement of telomerase processivity by POT1-TPP1, in contrast to other single amino acid mutations. \"    ///    \"Chimeric human-fish telomerases that contained the human TEN domain were active but not stimulated by POT1-TPP1, showing that additional determinants of processivity lie outside the TEN domain. \"'), ('10557', 'RARA_PL', '', 'RARA', 'PL', '25223426', '10', '', 'ISH', '', 'Oncogene', '', 'Receptor', 'Transcription_Factor', '', '', 'This report presents a case of acute promyelocytic leukaemia (APL) with the promyelocytic leukaemia-retinoic acid receptor alpha (PML-RARA) gene insertional translocation and a chromosome 21 abnormality in a 29-year-old XYY male patient.     ///    Acute promyelocytic leukaemia with a PML-RARA insertional translocation and a chromosome 21 abnormality in XYY syndrome: case report.. '), ('10558', 'MMP2_EMMPRIN', '', 'MMP2', 'EMMPRIN', '19921476', '10', '', '', '', '', '', '', '', '', '', 'A combined detection of EMMPRIN/MMP-2 co-expression may benefit us in prediction of a poor survival of PCMM.. '), ('10559', 'KRAS_EGFR', '', 'KRAS', 'EGFR', '25582278', '10', 'lung cancer;adenocarcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'EGFR/KRAS mutations and EML4-ALK fusions were similar between GGO and solid adenocarcinomas. '), ('10560', 'P14_P12', '', 'P14', 'P12', '8186417', '10', '', 'ISH', '', '', '', '', '', '', '', ' The gene for epidermal growth factor receptor (EGFR) has been localized to the p14-p12 region of human chromosome 7 by somatic cell hybridization and radioisotope in situ hybridization techniques. '), ('10561', 'RAB2_RAB1A', '', 'RAB2', 'RAB1A', '11799116', '10', 'cystic fibrosis', '', '', '', '', '', '', '', '', 'Remarkably, in a cell type-specific manner, processing of CFTR from the core-glycosylated (band B) ER form to the complex-glycosylated (band C) isoform followed a non-conventional pathway that was insensitive to dominant negative Arf1, Rab1a/Rab2 GTPases, or the SNAp REceptor (SNARE) component syntaxin 5, all of which block the conventional trafficking pathway from the ER to the Golgi. '), ('10562', 'TLS_CHOP', 't(12;16)  / ', 'TLS', 'CHOP', '9624148', '10', 'liposarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'Human translocation liposarcoma-CCAAT/enhancer binding protein (C/EBP) homologous protein (TLS-CHOP) oncoprotein prevents adipocyte differentiation by directly interfering with C/EBPbeta function..     ///    \"Being that CHOP is a member of the C/EBP transcription factor family, proteins that comprise part of the adipocyte differentiation machinery, we examined whether TLS-CHOP blocked adipocyte differentiation by directly interfering with C/EBP function. \"    ///    \"In contrast, the TLS-CHOP basic region was dispensable, making it unlikely that the inhibitory effect of TLS-CHOP is attributable to unscheduled gene expression resulting from TLS-CHOP\'s putative transactivation activity. \"    ///    This effect of TLS-CHOP required a functional leucine zipper domain and correlated with its ability to heterodimerize with C/EBPbeta and inhibit C/EBPbeta DNA binding and transactivation activity in situ.     ///    \"Together, the results demonstrate that TLS-CHOP blocks adipocyte differentiation by directly preventing C/EBPbeta from binding to and transactivating its target genes. \"    ///    TLS-CHOP was extremely effective at blocking adipocyte differentiation when expressed at a level comparable to that observed in human myxoid liposarcoma.     ///    \"Using a single-step retroviral infection protocol, either wild-type or mutant TLS-CHOP were co-expressed along with C/EBPbeta in na?ve NIH3T3 cells, and their ability to inhibit C/EBPbeta-driven adipogenesis was determined. \"'), ('10563', 'MDR1_P-gp', '', 'MDR1', 'P-gp', '7891222', '10', 'neuroblastoma\r\r', 'ISH', '', '', '', '', '', '', '', 'Expression of mdr1/P-glycoprotein and p110 in neuroblastoma.. '), ('10564', 'MYB_NFIB', '', 'MYB', 'NFIB', '21526958', '9', 'adenoid cystic carcinoma;squamous cell carcinoma;mucoepidermoid carcinoma\r\r', 'ISH', '', '', '', '', '', 'KB', 'Seq', 'The MYB-NFIB translocations have recently been identified in adenoid cystic carcinomas.    ///    The MYB-NFIB translocations have recently been identified in adenoid cystic carcinomas. '), ('10565', 'NPM_ALK', '', 'NPM', 'ALK', '14586401', '8', 'B cell lymphoma;anaplastic large cell lymphoma;lymphoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', '', '', 'The NPM-ALK kinase is active in primary tumour tissue and forms a multimeric complex with tyrosine-phosphorylated proteins, that is, Shc.     ///    Lymphomas develop in two transgenic lines in which the Vav promoter regulates NPM-ALK expression.     ///    The new transgenic models provide a system for investigating the oncogenic events mediated by NPM-ALK in situ and a physiologically relevant context for developing tyrosine kinase inhibitor therapies of potential use in the clinic..     ///    Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase.. '), ('10566', 'EML4_ALK', '', 'EML4', 'ALK', '24123310', '5', 'non small cell lung cancer', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'The aim of our study was to investigate novel mutations of Eph genes (EPHA1-8, EPHB1-4, EPHB6) and their association with clinically relevant mutations in BRAF, EML4-ALK, EGFR, INSR, KDR, KRAS, MET, PDGFRA, PDGFRB, PIK3, PTEN, RET, and TP53 in NSCLC patients. '), ('10567', 'PDGFRA_FIP1L1', '', 'PDGFRA', 'FIP1L1', '17215855', '5', 'myeloproliferative disorder;chronic myeloid leukemia;myeloid leukemia;leukemia\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'FIP1L1-PDGFRA in chronic eosinophilic leukemia and BCR-ABL1 in chronic myeloid leukemia affect different leukemic cells..     ///    \"Fluorescence in situ hybridization specific for BCR-ABL1 and for FIP1L1-PDGFRA was combined with cytomorphology or with lineage-restricted monoclonal antibodies and applied in CML and CEL, respectively. \"    ///    \"This study provided evidence for marked differences in the leukemic masses which are targeted by imatinib in CEL or CML, as harboring FIP1L1-PDGFRA or BCR-ABL1.. \"'), ('10568', 'EML4_ALK', '', 'EML4', 'ALK', '23617234', '5', 'lung cancer;adenocarcinoma\r\r', '', 'Kinase', 'Oncogene', '', '', '', 'KB', 'Seq', 'To our knowledge, this is the first report of synchronous, bilateral lung adenocarcinomas composed of EML4-ALK positive and negative ones..    ///    A case of synchronous bilateral lung cancers: EML4-ALK positive adenocarcinoma in the right lung and adenocarcinoma in situ (the former bronchioloalveolar carcinoma) in the left lung.    ///    \"The woman had EML4-ALK positive lung adenocarcinoma in the right lower lung while adenocarcinoma in situ in the left upper lung, which was EML4-ALK negative. \"    ///    A case of synchronous bilateral lung cancers: EML4-ALK positive adenocarcinoma in the right lung and adenocarcinoma in situ (the former bronchioloalveolar carcinoma) in the left lung..     ///    Reported herein is a case of synchronous EML4-ALK positive lung adenocarcinoma and adenocarcinoma in situ in the bilateral lungs of a 55-year-old Japanese woman.     ///    \"To our knowledge, this is the first report of synchronous, bilateral lung adenocarcinomas composed of EML4-ALK positive and negative ones.. \"'), ('10569', 'TMPRSS2_ERG', '', 'TMPRSS2', 'ERG', '24072184', '5', 'prostate cancer;prostatic intraepithelial neoplasia\r\r', 'ISH', '', '', '', '', '', 'KB', 'Seq', 'We compared tissue PCA3 expression with tissue level ERG expression and matched pre-prostatectomy urine PCA3 and TMPRSS2-ERG levels.    ///    Evaluation of tissue PCA3 expression in prostate cancer by RNA in situ hybridization--a correlative study with urine PCA3 and TMPRSS2-ERG.. '), ('10570', 'SYT_SSX2', '', 'SYT', 'SSX2', '15105652', '4', 'rhabdoid tumor', '', '', '', '', '', '', '', '', 'SYT-SSX2 transcripts were detected in all 3 cases. '), ('10571', 'NAB2_STAT6', '', 'NAB2', 'STAT6', '26253700', '4', 'prostate cancer;solitary fibrous tumor\r\r', '', '', 'Oncogene', '', '', 'Transcription_Factor', 'KB', '', 'Capture transcriptome profiling from FFPE revealed two oncogenic fusions: the pathognomonic NAB2-STAT6 inversion and a therapeutically actionable BRAF fusion, which may drive this specific cancer\'s aggressive phenotype.    ///    \"Capture transcriptome profiling from FFPE revealed two oncogenic fusions: the pathognomonic NAB2-STAT6 inversion and a therapeutically actionable BRAF fusion, which may drive this specific cancer\'s aggressive phenotype. \"'), ('10572', 'CD74_NRG1', '', 'CD74', 'NRG1', '25531467', '0', 'adenoid cystic carcinoma;squamous cell carcinoma;lung cancer;adenocarcinoma\r\r', '', '', '', '', '', '', 'KB', '', 'Our analysis confirms the recently reported CD74-NRG1 fusion and suggests that NRG1, NF1 and Hippo pathway fusions may play important roles in tumours without known driver mutations.    ///    \"Our analysis confirms the recently reported CD74-NRG1 fusion and suggests that NRG1, NF1 and Hippo pathway fusions may play important roles in tumours without known driver mutations. \"'), ('10573', 'SYT_SSX2', '', 'SYT', 'SSX2', '10191774', '0', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'SYT-SSX1 fusion was found in 4 patients and SYT-SSX2 in 5. '), ('10574', 'SYT_SSX1', '', 'SYT', 'SSX1', '10191774', '0', 'synovial sarcoma;sarcoma\r\r', '', '', '', '', '', '', '', '', 'SYT-SSX1 fusion was found in 4 patients and SYT-SSX2 in 5. '), ('10575', 'RANBP2_ALK', '', 'RANBP2', 'ALK', '21164297', '-3', 'sarcoma\r\r', 'ISH', 'Kinase', 'Oncogene', '', '', '', 'KB', '', 'Fluorescence in situ hybridization was positive for ALK gene rearrangement in 9 cases, and in 3 cases tested, a RANBP2-ALK fusion was detected by reverse transcription polymerase chain reaction. '), ('10576', 'MYH11_CBFB', '', 'MYH11', 'CBFB', '9156661', '-4', 'acute myeloid leukemia;myeloid leukemia;leukemia\r\r', '', '', '', '', '', '', '', '', 'Using reverse transcriptase-polymerase chain reaction analysis, we tried to detect CBFB/MYH11 chimeric mRNA in blasts from our patients, however, were unable to detect any chimeric mRNA in the blasts: The absence of CBFB/MYH11 transcripts in this case suggests that rare chimeric products might be formed as a result of inv 16 that could not be detected by the primer sets used in this study.     ///    Analyzing leukemias with inv 16 which do not have a typical CBFB/MYH11 chimeric mRNA might lead to understanding an alternative pathogenesis for acute leukemia with inv 16.. '), ('10577', 'SSX_SYT', '', 'SSX', 'SYT', '16740029', '-5', 'synovial sarcoma;sarcoma\r\r', 'ISH', '', '', '', '', '', '', '', 'The SYT-SSX fusion protein, unique to SS, may independently increase cyclin D1. '), ('10578', 'NTRK3_ETV6', '', 'NTRK3', 'ETV6', '10658907', '-16', 'clear cell sarcoma;sarcoma\r\r', '', 'Kinase', '', '', '', '', 'KB', 'Seq', ' We report the development of a reverse transcriptase polymerase chain reaction assay that reliably detects the ETV6-NTRK3 chimeric RNA characteristic of infantile fibrosarcoma and the cellular variant of congenital mesoblastic nephroma (CMN) in formalin-fixed, paraffin-embedded tissue blocks.     ///    Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors.. '), ('10579', 'EWSR1_CREB1', '', 'EWSR1', 'CREB1', '23252871', '-22', 'chondrosarcoma;sarcoma', '', '', '', '', '', 'Transcription_Factor', 'KB', '', 'Our reverse transcription-polymerase chain reaction using the formalin-fixed, paraffin-embedded tumor tissues detected EWSR1-CREB1 fusion transcript, but could not demonstrate EWSR1-ATF1 fusion or EWSR1/TAF15/TFG-NR4A3 fusion.    ///    \"Our reverse transcription-polymerase chain reaction using the formalin-fixed, paraffin-embedded tumor tissues detected EWSR1-CREB1 fusion transcript, but could not demonstrate EWSR1-ATF1 fusion or EWSR1/TAF15/TFG-NR4A3 fusion. \"    ///    \"Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature.. \"');
COMMIT;

