 The chromosomal translocation t(8;21), generating the AML1-ETO fusion protein, is frequently associated with French-American-British (FAB) type M2 acute myeloid leukemia (AML).     ///    AML1-ETO inhibits normal definitive hematopoiesis and blocks erythroid differentiation.     ///    Several mechanistic models for the role of AML1-ETO in leukemia development have emerged over the last decade.     ///    This review will consider the clinical and mechanistic significance of erythroid inhibition by AML1-ETO.     ///    "Because erythropoiesis occurs in a RUNX-independent manner, this dominant-negative ""classical"" model cannot explain the prominent repression of red-cell development by AML1-ETO. "