The present study shows that EZR-ROS1 plays an essential role in the oncogenesis of NSCLC harboring the fusion gene.     ///    "These data suggest that the EZR-ROS1 is a pivotal oncogene in human NSCLC, and that this animal model could be valuable for exploring therapeutic agents against ROS1-rearranged lung cancer.. "    ///    "Most importantly, established transgenic mouse lines specifically expressing EZR-ROS1 in lung alveolar epithelial cells developed multiple adenocarcinoma nodules in both lungs at an early age. "    ///    EZR-ROS1 was identified in four female patients of lung adenocarcinoma.     ///    "These data suggest that the EZR-ROS1 is a pivotal oncogene in human NSCLC, and that this animal model could be valuable for exploring therapeutic agents against ROS1-rearranged lung cancer.."