In this study, we used antisense oligonucleotides to block the expression of the SYT-SSX fusion gene in synovial sarcoma cells.     ///    Gene expression profile by blocking the SYT-SSX fusion gene in synovial sarcoma cells.     ///     Increasing evidence suggests that the SYT-SSX fusion gene plays an important role in synovial sarcoma development and progression.     ///    "Our study provides some clues to elucidate the signaling pathways of the SYT-SSX fusion gene, as well as it demonstrates a valuable model system for search for other SYT-SSX targets.. "    ///    "Herewith, using a filter containing 1176 cancer-relevant genes, we found that the DNA repair gene XRCC4 and the DNA mismatch repair gene MSH2 were downregulated, whereas the gene encoding for the serine/threonine protein kinase PRK (also known as CNK), and the macrophage inhibitory cytokine MICI (also known as PLAB) were upregulated after the inhibition of SYT-SSX. "    ///    "Consistently, the protein expression of XRCC4 was found to be decreased after SYT-SSX inhibition, whereas there were no detectable changes for the other gene products. "    ///    "However, very little is known about the downstream targets of SYT-SSX. "    ///    "By comparing SYT-SSX inhibited cells with noninhibited cells, the gene expression profile was analysed using cDNA microarray and established by real-time PCR. "    ///    Identification of XRCC4 as a putative SYT-SSX target gene.. 