Of 38 cases of M2-AML without t(8;21) on conventional cytogenetics(CC) analysis, 4 cases showed positivity for AML1/ETO fusion transcript, which included 2 cases with typical signal model and 2 with insertion.     ///    "Interphase-FISH was performed in 108 cases of AML with M5, M4, M2, M3 subtypes including 103 cases with normal karyotypes, 4 cases with chromosomal abnormalities other than specific chromosomal rearrangements using chromosome translocation probe such as AML1/ETO, PML/RAR?, CBF?/MYH11 and MLL. "    ///    "Interphase-FISH can detect specific chromosome rearrangements such as AML1/ETO, PML/RAR? or CBF?/MYH11 in some AML cases with normal karyotype, though it seemed less useful for the detection of MLL rearrangement.. "