 In pro-B cell acute lymphoblastic leukemia (ALL), expression of the E2A-HLF fusion gene as a result of t(17;19)(q22;p13) is associated with poor prognosis, hypercalcemia, and hemorrhagic complications.     ///    "Annexin II was expressed at high levels in APL cells and in each of 4 t(17;19)+ leukemia cell lines, and annexin II expression was induced by enforced expression of E2A-HLF in leukemia cells. "    ///    "Moreover, E2A-HLF increased annexin II expression in IL-3-dependent cells in the absence of the cytokine. "    ///    These findings indicate that E2A-HLF induces annexin II by substituting for cytokines that activate downstream pathways of Ras..     ///    Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein..     ///    We previously reported that the E2A-HLF fusion protein protects interleukin-3 (IL-3)-dependent lymphoid cells from apoptosis caused by cytokine starvation. 