During this process, the increased levels of COX-2/IL-8 and the subsequent elevation of ROS production induced NF-?B nuclear translocation and IL-8 secretion.     ///    Blockade of tropomyosin receptor kinase A (TrkA) by an inhibitor or short hairpin RNA inhibited the levels of COX-2/IL-8 and the nuclear translocation of NF-?B but did not suppress the increased ROS level. 