 Translocation (12;21), the most frequent chromosomal aberration in childhood acute lymphoblastic leukemia, creates TEL/AML1 fusion gene.     ///    "TEL/AML1 silencing neither decreased cell viability, nor induced apoptosis. "    ///    "Using most efficient siRNAs, we achieved an average of 74-86% TEL/AML1 protein knockdown in REH and UOC-B6 leukemic cells, respectively. "    ///    "Our data suggest that though TEL/AML1 is important for the (pre)leukemic clone development, it may be dispensable for leukemic cell survival and would not be a suitable target for gene-specific therapy.. "    ///    "To address its role for leukemic cell survival, we applied RNA interference to silence TEL/AML1 in leukemic cells. "    ///    Revealing the role of TEL/AML1 for leukemic cell survival by RNAi-mediated silencing..     ///    "Opposite effects on cell cycle distribution and proliferation were induced by AML1 silencing, thus, supporting our hypothesis that TEL/AML1 may block AML1-mediated promotion of G1/S progression through the cell cycle. "    ///    "In line with the lack of major effect on phenotype, we found no significant changes in clonogenic potential and global gene expression pattern upon TEL/AML1 depletion. "    ///    We designed and tested 11 different oligonucleotides targeting the TEL/AML1 fusion site. 