SiRNA-directed Kap?2 knockdown significantly reduced HMW-FGF2's nuclear translocation.     ///    Decreased PTEN expression and activated Akt signaling were observed upon HMW-FGF2 overexpression and might mediate pro-survival effect of FGF2.     ///    "Nuclear accumulation of HMW-FGF2 strongly promotes glioblastoma cell proliferation, yet mechanism governing such cellular distribution remains unexplored. "    ///    "We found HMW-FGF2, but not 18K-FGF2, is primarily located in the nucleus and interacts with nuclear transport protein Karyopherin-?2/Transportin (Kap?2). "    ///    "Moreover, inhibiting Ran GTPase activity also resulted in decreased HMW-FGF2 nuclear accumulation. "    ///    Proliferation of T98G cells is greatly enhanced with transfections HMW-FGF2. 