 The chromosomal translocation products AML1-ETO and PML-RARalpha contribute to the pathogenesis of leukemias.     ///    "Here, we demonstrate that both AML1-ETO and PML-RARalpha are degraded by the ubiquitin-proteasome system and that their turnover critically depends on the E2-conjugase UbcH8 and the E3-ligase SIAH-1. "    ///    "Contrary to its role in HDAC2 degradation, the E3-ligase RLIM does not target AML1-ETO and PML-RARalpha for ubiquitin-dependent elimination. "    ///    Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.. 