In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 ?? 10(-9)), ANK3 (rs10994359, P = 2.5 ?? 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 ?? 10(-9)).. 