Here, we show that targeting of AML1-ETO to essential, MYB-dependent gene promoters induces t(8;21)-restricted cell death.     ///    Transcriptional repression of AML1-dependent genes by AML1-ETO and associated corepressors represents the pathogenetic mechanisms of t(8;21).     ///    This protein associated with AML1-ETO and directed the complex to MYB-responsive promoters in vitro and in vivo.     ///    "This translocation produces the AML1-ETO fusion protein, which binds to AML1 target promoter sequences. "    ///    "In the presence of AML1-ETO, the chimeric protein repressed the activity of MYB-responsive promoters, rapidly induced apoptosis, and specifically inhibited colony growth. "