Interestingly, EML4-ALK fusion genes are more frequently found in younger patients and associated with less-differentiated carcinomas.    ///    "We have identified EML4-ALK fusion genes in 8 out of 95 carcinoma cases, accounting for 8.42% in Chinese male never-smokers with NSCLC."    ///    EML4-ALK fusion genes were detected using one-step real time RT-PCR and DNA sequencing.     ///    "Interestingly, EML4-ALK fusion genes are more frequently found in younger patients and associated with less-differentiated carcinomas. "    ///    "Thus, characterization of EML4-ALK fusion genes and clinical features of resulting carcinomas would be a great benefit to disease diagnosis and designing customized treatment plans. "    ///    "We have identified EML4-ALK fusion genes in 8 out of 95 carcinoma cases, accounting for 8.42% in Chinese male never-smokers with NSCLC. "    ///    Non-small cell lung cancer with EML4-ALK translocation in Chinese male never-smokers is characterized with early-onset.    ///    "In this study, we have determined the frequency of EML4-ALK translocation in male never-smokers with NSCLC in a cohort of Chinese patients."    ///    EML4-ALK translocation is associated with early-onset and less-differentiated carcinomas..    ///    EML4-ALK translocation is associated with early-onset and less-differentiated carcinomas..     ///    The clinical features associated with EML4-ALK translocation were also investigated.     ///    Non-small cell lung cancer with EML4-ALK translocation in Chinese male never-smokers is characterized with early-onset..     ///    "In this study, we have determined the frequency of EML4-ALK translocation in male never-smokers with NSCLC in a cohort of Chinese patients. "    ///    The frequency of EML4-ALK translocation is strongly associated with smoking habits in Chinese male patients with higher frequency in male never-smokers.     ///    "Studies have suggested that EML4-ALK translocation occurs more frequently in never-smokers with NSCLC, especially in female patients. "    ///    "It has been suggested that EML4-ALK fusion is associated with the resistance in NSCLCs to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs), such as gefitinib and erlotinib. "