Our results imply that each of 1.16 > or = DI and the presence of the TEL-AML1 translocation confers a 50% decrease in lymphoblast MTXPG level.     ///    The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study..     ///    Hyperdiploidy was rare in lymphoblasts with the TEL-AML1 translocation (P = 0.047).     ///    Levels of lymphoblast MTXPGs were lower in those with than in those without the TEL-AML1 translocation (P = 0.004).     ///    We detected the TEL-AML1 and/or the AML1-TEL transcript in 30 (33%) of 91 patients studied.     ///    "However, the presence of TEL-AML1 or of hyperdiploidy accounted for only 22% of the variation of this value. "    ///    Both ploidy (P= 0.0015) and TEL-AML1 status (P= 0.0043) were independently and significantly correlated with the log of the lymphoblast MTXPG level.     ///    "When planning reduction of therapy for either of the two excellent outcome categories of hyperdiploid or TEL-AML1 BpALL, one should consider the difference between these two subgroups in the ability of lymphoblasts to accumulate MTXPGs.. "    ///    "The chimeric TEL-AML1 transcript, which has been associated with this translocation, can be detected in up to 25% of children with BpALL. "