 The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene has been identified as an oncogene in a subset of non-small cell lung cancers (NSCLC).     ///    "EML4-ALK translocation was also confirmed by fluorescence in situ hybridization assay, which revealed its substantial heterogeneity in both primary tumors and tumor-derived cell lines. "    ///    This approach led to the detection of EML4-ALK fusion in breast and colorectal carcinomas in addition to NSCLC.    ///    "To elucidate the functional significance of EML4-ALK, we examined the growth of cell lines harboring the fusion following EML4 and ALK silencing by small interfering RNA. "    ///    Besides previously known EML4-ALK variants 1 (E13.     ///    "Collectively, these findings show the recurrence of EML4-ALK fusion in multiple solid tumors and further substantiate its role in tumorigenesis.. "    ///    "Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.. "    ///    "Screening of a large collection of patient tumor samples showed the presence of EML4-ALK fusion in 2.4% of breast (5 of 209), 2.4% of colorectal (2 of 83), and in 11.3% of NSCLC (12 of 106). "