It is important to identify these cryptic and variant translocations because certain variants, including ZBTB16/RARA and STAT5B/RARA, are resistant to treatment with all-trans retinoic acid, arsenic trioxide, and anthracyclines.     ///    "With the exception of ZBTB16/RARA, these variants have similar morphologic and immunophenotypic features as classic APL. "