Double immunofluorescence in conjunction with confocal laser-scanning microscopy revealed that the SYT and SYT-SSX nuclear dots do not co-localize with known nuclear structures as e.g.     ///    The SSX2 protein exhibited a diffuse staining pattern whereas both the SYT and SYT-SSX proteins appeared in several nuclear dots.     ///    These antibodies specifically detected both these proteins and the SYT-SSX fusion proteins in transfected COS-1 cell extracts.     ///    The similar nuclear localization patterns of SYT and SYT-SSX suggest that the SYT-SSX fusion proteins are directed to SYT-associated nuclear domains where an abnormal function may be exerted..     ///    "Nuclear localization of SYT, SSX and the synovial sarcoma-associated SYT-SSX fusion proteins.. "