We aimed to provide a basis for the further development of the therapy for KIF5B-RET positive lung cancer patients.    ///    RT-PCR was used to screen for KIF5B-RET fusions in Chinese lung cancer patients.    ///    "To verify the oncogenic activity of KIF5B-RET kinase in lung cancer cells, we manipulated its expression genetically followed by colony formation and tumor formation assays. "    ///    "Our data suggest that KIF5B-RET promotes the cell growth and tumorigenicity of non-small cell lung cancers through multilevel activation of STAT3 signaling, providing possible strategies for the treatment of KIF5B-RET positive lung cancers.. "    ///    "The mechanism by which KIF5B-RET kinase induces proliferation was investigated by western blot, coimmunoprecipitation, and administration of RET, MAPK and STAT3 inhibitors. "    ///    "In this study, we verified the oncogenic activity of KIF5B-RET fusion and investigated how KIF5B-RET activates the specific signaling pathways for cellular transformation. "    ///    Our study identified a KIF5B-RET fusion in Chinese NSCLC patients and demonstrated that KIF5B-RET transfected cells showed a significantly increased proliferation rate and colony-forming ability.     ///    KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers.     ///    KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer.. 