The position of XIC/XIST in the reciprocal products of the translocation was determined by XIST-specific FISH and computer enhancement.     ///    Our study in differentiated cells provides a visual demonstration that physical separation from XIC/XIST does not result in reactivation of inactive X-chromosome material and that X inactivation is not spread to the translocated autosomes irrespective of the position of XIC/XIST.     ///    Position effect of translocations involving the inactive X chromosome: physical linkage to XIC/XIST does not lead to long-range de novo inactivation in human differentiated cells..     ///    This observation suggests that physical linkage to XIC/XIST does not lead to de novo inactivation of autosomal material..     ///    "In other experiments, the Xq13 region carrying XIC/XIST was localized by computer enhancement of the DAPI banding pattern. "