The most common molecular alterations in thyroid cancer include BRAF and RAS point mutations and RET/PTC and PAX8/PPAR ? rearrangements.     ///    "The diagnostic role of BRAF mutations has been studied most extensively, and recent studies also demonstrated a significant diagnostic utility of RAS, RET/PTC, and PAX8/PPAR ? mutations, particularly in thyroid fine-needle aspiration samples with indeterminate cytology. "