Finally, NPM-ALK impeded the expected DNA damage-induced translocation of MSH2 out of the cytoplasm.     ///    "Using co-immunoprecipitation, we found that increasing levels of NPM-ALK expression in HEK293 cells resulted in decreased levels of MSH6 bound to MSH2, whereas MSH2??NPM-ALK binding was increased. "    ///    MSH2 was found to be tyrosine phosphorylated in the presence of NPM-ALK.     ///    "In this study, we found in vitro evidence that enforced expression of NPM-ALK in HEK293 cells suppressed MMR function. "    ///    "To conclude, our data support a model in which the suppression of MMR by NPM-ALK is attributed to its ability to interfere with normal MSH2 biochemistry and function.. "    ///    Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoprotein..     ///     The fusion tyrosine kinase NPM-ALK is central to the pathogenesis of ALK-positive anaplastic large cell lymphoma (ALK(+)ALCL). 