On the other hand, TNF-? could induce Akt and p42/p44 MAPK translocation from the cytosol into the nucleus, which was inhibited by AG490, AG1296, or LY294002.     ///    "We showed that TNF-? markedly stimulated Jak2, PDGFR, Akt, and p42/p44 MAPK phosphorylation, which were attenuated by their respective inhibitors. "    ///    "In addition, TNF-?-induced p42/p44 MAPK phosphorylation was reduced by AG1296 or LY294002. "