 The OTT-MAL/RBM15-MKL1 fusion protein is the result of the recurrent translocation t(1;22) in acute megakaryocytic leukemia in infants.     ///    "OTT-MAL deregulation reflects its independence from control by G-actin, which fails to interact with OTT-MAL in coimmunoprecipitation experiments. "    ///    "OTT-MAL also caused a delayed induction of the MAL-independent, ternary complex factor-dependent target genes c-fos and egr-1 and the mitogen-activated protein kinase/Erk pathway. "    ///    Our data suggest that the deregulated activation of MAL-dependent and -independent promoters results in tissue-specific functions of OTT-MAL..     ///    OTT-MAL is a deregulated activator of serum response factor-dependent gene expression..     ///    Here we demonstrate that OTT-MAL is a constitutive activator of SRF and target gene expression.     ///    "With testing in heterologous tissue culture systems, however, we observed considerable antiproliferative effects of OTT-MAL. "    ///    OTT-MAL localizes to the nucleus and is not regulated by upstream signaling. 