The activation of STAT5 by PML/RAR? and DEK/NUP214 was confirmed in t(15;17)(PML/RAR?) and t(6;9)(DEK/NUP214)-positive patients as compared to normal CD34+ cells.     ///    "Until now the biology of AML-associated fusion proteins (AAFPs), such as the t(15;17)-PML/RAR?, t(8;21)-RUNX1/RUNX1T1 and t(6;9)-DEK/NUP214, all able to induce AML in mice, was investigated in different models and genetic backgrounds, not directly comparable to each other. "    ///    "These AAFPs exerted differential effects on HSCs and PML/RAR?, similar to DEK/NUP214, induced a leukemic phenotype from a small subpopulation of HSCs with a surface marker pattern of long-term HSC and characterized by activated STAT3 and 5. "    ///    The activation of STAT5 was reduced upon the exposure to Arsenic which was accompanied by apoptosis in both PML/RAR?- and DEK/NUP214-positive leukemic cells. 