These observations present molecular evidence for an association between the PML/SP100 NBs and the chromatin nuclear compartment.     ///    "Both HP1 and SP100-HMG concentrate in the PML/SP100 NBs, and overexpression of SP100 leads to enhanced accumulation of endogenous HP1 in these structures. "    ///     The PML/SP100 nuclear bodies (NBs) were first described as discrete subnuclear structures containing the SP100 protein. 