 The CALM-AF10 fusion gene, which results from a t(10;11) translocation, is found in a variety of hematopoietic malignancies.     ///    "These results suggest that during leukemogenesis, CALM-AF10 plays its critical roles in the cytoplasm.. "    ///    "To investigate the influence of localization on leukemogenesis involving CALM-AF10, we determined the nuclear export signal (NES) within CALM that is necessary and sufficient for cytoplasmic localization of CALM-AF10. "    ///    Certain HOXA cluster genes and MEIS1 genes are upregulated in patients and mouse models that express CALM-AF10.     ///    "however, it is not clear where CALM-AF10 acts to induce leukemia. "    ///    Mutations in the NES eliminated the capacity of CALM-AF10 to immortalize murine bone-marrow cells in vitro and to promote development of acute myeloid leukemia in mouse models. 