 It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is causative for oncogenic transformation.     ///    "Previously published reports showed that CBFB-MYH11 dominantly inhibits RUNX1 and CBFB, and such inhibition has been suggested as the mechanism for leukemogenesis. "    ///    "However, the mechanism by which CBFB-MYH11 initiates leukemogenesis is not clear. "    ///    The expression of all 3 genes was detected in most human and murine CBFB-MYH11(+) leukemia samples. 