Bcl-2/Ig gene rearrangement was determined by polymerase chain reaction targeting the usual breakpoint regions of the t(14;18).     ///    The frequency of the bcl-2/Ig gene rearrangement is estimated to be of one translocation in 1 x 10(2) to 1 x 10(3) peripheral blood mononuclear cells.     ///    Multiple bcl-2/Ig gene rearrangements in persistent polyclonal B-cell lymphocytosis..     ///    We conclude that persistent polyclonal B-cell lymphocytosis is associated with bcl-2/Ig gene rearrangement.     ///    "Owing to the role of Bcl-2 oncogene in inhibition of apoptosis, we have investigated the presence of the bcl-2/Ig gene rearrangement. "    ///    "Bcl-2/Ig gene rearrangement was identified in all six patients and, more importantly, multiple rearrangements were present in five patients. "