Our study shows that the DEK-NUP214 fusion gene increases proliferation by upregulation of mTOR, suggesting that patients with leukemias carrying DEK-NUP214 may benefit from treatment with mTOR inhibitors..     ///     The t(6;9)(p23;q34) chromosomal translocation is found in 1% of acute myeloid leukemia and encodes the fusion protein DEK-NUP214 (formerly DEK-CAN) with largely uncharacterized functions.     ///    We expressed DEK-NUP214 in the myeloid cell lines U937 and PL-21 and studied the effects on cellular functions.     ///    "In this study, we demonstrate that expression of DEK-NUP214 increases cellular proliferation. "    ///    Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR.. 