ALK fusions occur in approximately 50% of ALCLs, and among these, 80% have the t(2;5) translocation with NPM-ALK expression.     ///    The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling..     ///    Expression of NPM-ALK results in ERK1/2 activation and transcriptional up-regulation of JUNB.     ///    "In conjunction with NPM-ALK, JunB enhances cell cycle progression and may therefore represent a therapeutic target.. "