MECT1-MAML2 was found to bind to CREB, recruit p300/CBP into the CREB complex through a binding domain on MAML2, and constitutively activate CREB-dependent transcription.     ///    The transforming activity of MECT1-MAML2 was markedly reduced by blocking CREB DNA binding.     ///    Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation..     ///    "Here, we demonstrate that the MECT1-MAML2 fusion protein induces expression of multiple genes known to be CREB transcriptional targets. "