[Prognostic significance of the NPM-ALK fusion gene in bone marrow and peripheral blood for patients with anaplastic large cell lymphoma]..     ///     To investigate the expression of NPM- ALK fusion gene in bone marrow (BM) and peripheral blood (PB) in anaplastic large cell lymphoma (ALCL) patients and its prognostic significance.     ///    "NPM- ALK fusion gene of 21 BM and 15 PB samples from patients with NPM-ALK positive ALCL was detected by RT- PCR, and the relationship between NPM- ALK expression and prognosis and clinical characters was evaluated. "    ///    We could evaluate the minimal disseminated disease of NPM-ALK positive ALCL patients by screening the NPM-ALK fusion gene in BM and PB by RT-PCR.     ///    86.7% patients had a concordant results of NPM-ALK expression in PB and BM.     ///    "Patients with a positive NPM-ALK expression in BM had a 3-years EFS of (35.6??18.6)%, compared with (91.7??8.0)% for patients with negative NPM-ALK (P=0.038). "