Although EML4-ALK is reported to be formed by inversion of chromosome 2, other mechanisms of this gene fusion remain unknown.     ///    This study aimed to examine the mechanism of EML4-ALK rearrangement using a novel cell line with the EML4-ALK fusion gene.     ///    "These observations provided the first evidence that EML4-ALK fusion in JFCR-LC649 cells was formed in chromosome 2 by a distinct mechanism of genomic rearrangement, termed chromothripsis. "    ///    A novel mechanism of EML4-ALK rearrangement mediated by chromothripsis in a patient-derived cell line..     ///    Our results suggested that chromothripsis may be a mechanism of oncogenic rearrangement of EML4-ALK.     ///     EML4-ALK is a driver oncogene in non-small-cell lung cancer (NSCLC) and has been developed into a promising molecular target for antitumor agents. 