 The Nup98-HoxD13 (NHD13) fusion gene was identified in a patient with therapy-related myelodysplastic syndrome (MDS).     ///    Progressive genomic instability in the Nup98-HoxD13 model of MDS correlates with loss of the PIG-A gene product..     ///    "These findings clearly demonstrate a state of progressive genomic instability that increases the likelihood of a ""second hit"" or complimentary mutation later in the disease to trigger development of acute leukemia and underscores the mechanistic nature of how the NUP98-HoxD13 transgene induces progression of MDS to acute leukemia. "