In the absence of CD5-CK2 signaling, we observed decreased activity of S6K and attenuated nuclear translocation of ROR?t (ROR is retinoic acid receptor related orphan receptor).     ///    These results reveal a novel and essential function of the CD5-CK2 signaling pathway and GSK3-IFN-? axis in regulating Th-cell differentiation and provide a possible means to dampen Th17-type responses in autoimmune diseases.     ///    Genetic ablation of the CD5-CK2 signaling pathway attenuated TCR-induced AKT activation and consequently increased activity of GSK3 in Th17 cells.     ///    "In our study, the CD5-CK2 signaling pathway enhanced TCR-induced activation of AKT and promoted the differentiation of Th17 cells by two independent mechanisms: inhibition of glycogen synthase kinase 3 (GSK3) and activation of mTOR. "