Beta-catenin expression was strongly membranous in IL-10(-/-) mice, while 87.50% of AOM/DSS-induced tumors showed cytoplasmatic and/or nuclear translocation of beta-catenin.     ///    "CIN was detected in 81.25% of all murine CACs induced by AOM/DSS, while all carcinomas that arose in IL-10(-/-) mice were chromosomally stable. "    ///    The AOM/DSS model (n?=?23) and IL-10(-/-) mice (n?=?8) were applied to monitor malignancy development via endoscopy and to analyze premalignant and malignant stages of CACs.     ///    "AOM/DSS-colitis, but not IL-10(-/-) mice, could provide a powerful murine model to mechanistically investigate CIN in colitis-associated carcinogenesis.. "