One model uses the 'knock-in' approach to induce leukaemia by p190 BCR-ABL1(ref.     ///    Reversibility of acute B-cell leukaemia induced by BCR-ABL1..     ///    "The most common form, p210 BCR-ABL1, is found in more than 90% of patients with chronic myelogenous leukaemia (CML) and in up to 15% of adult patients with de novoacute lymphoblastic leukaemia (ALL). "    ///    We have taken a new approach to determine if ablation of the genetic abnormality is sufficient for reversion by generating a conditional transgenic model of BCR-ABL1 (also known as BCR-ABL)-induced leukaemia. 