We report here the cellular localization of the HRX/ALL1 protein as well as that of the HRX/ALL1-eps15 fusion protein, the result of the t(1;11) (p32-q23) translocation of acute myeloid leukemias.     ///    The localization of the HRX/ALL1 protein to specific nuclear subdomains is altered by fusion with its eps15 translocation partner..     ///     Translocations involving the HRX/ALL1 locus at chromosomal region 11q23 are among the most frequent cytogenetic abnormalities in acute leukemias.     ///    The HRX/ALL1 protein is a putative transcription factor that has been implicated in developmental regulation in mammals.     ///    "Thus, the fusion with eps15 alters the cellular compartmentalization of HRX/ALL1, providing a putative mechanism for activation of HRX/ALL1 by 11q23 abnormalities.. "    ///    The HRX/ALL1 protein was localized to both the cytoplasm and the nucleus.     ///    The HRX/ALL1-eps15 localized exclusively to the nucleus within bodies that were smaller and more numerous than the HRX/ALL1 nuclear bodies.     ///    HRX/ALL1 fusion with an unknown partner in leukemia blasts with 11q23 abnormalities had similar morphological features.     ///    11q23 translocations involve different chromosome partners and lead to the formation of HRX/ALL1 fusion proteins. 