Synthetic RNAs corresponding to EWSR1-FLI1 were used as substrates.    ///    Cleavage of the Ewing tumour-specific EWSR1-FLI1 mRNA by hammerhead ribozymes..     ///    "Therefore, inactivation of EWSR1-FLI1 is an interesting strategy for EFT therapy. "    ///    The RNA corresponding to EWSR1-FLI1 is accessible for ribozyme mediated inactivation and ribozymes are able to cleave EWSR1-FLI1 specific RNA in the presence of a high background of normal cellular RNAs..     ///    A ribozyme with specificity for EWSR1-FLI1 was developed and the activity in vitro was investigated.     ///    "In the majority of EFT, EWSR1-FLI1 (Ewing sarcoma breakpoint region 1-Friend leukaemia virus integration 1) fusion proteins can be detected and EWSR1-FLI1 substantially contributes to the malignant phenotype of EFT."    ///    "In the majority of EFT, EWSR1-FLI1 (Ewing sarcoma breakpoint region 1-Friend leukaemia virus integration 1) fusion proteins can be detected and EWSR1-FLI1 substantially contributes to the malignant phenotype of EFT. "