 AML1-ETO fusion protein is a product of chromosome translocation t(8;21) frequently occurred in acute myeloid leukemia (AML), but its sole expression appears to fail to cause overt leukemia in vivo.     ///    "Additionally, AML1-ETO protein also increased AhR expression, a ligand-activated transcription factor that mediates PAHs-induced CYP1A1 gene expression. "    ///    Luciferase reporter system was used to detect the regulation of AML1-ETO on CYP1A1 transcription.     ///    "In line with the effect, we also found that AML1-ETO induction upregulated CYP1A1 expression, which was dependent on AML1-binding motif in the promotor of CYP1A1 gene. "    ///    Our results showed that AML1-ETO induction significantly increased the formation of carcinogen benzopyrene-DNA adducts in leukemic cells.     ///    "These data, combined with its inhibitory effect on DNA repair as reported previously, propose that the presence of AML1-ETO increases the susceptibility of cells to chemical carcinogens, which favors the development of additional genetic alterations.. "    ///    "In this study, we investigated whether AML1-ETO expression impinged on action of chemical carcinogens-DNA adduct formation. "    ///    AML1-ETO fusion protein was conditionally induced in engineered U937-A/E 9/14/18 cells.     ///    Leukemogenic AML1-ETO fusion protein increases carcinogen-DNA adduct formation with upregulated expression of cytochrome P450-1A1 gene.. 