 The full-length AML1-ETO (AE) fusion gene resulting from t(8;21)(q22;q22) in human acute myeloid leukemia (AML) is not sufficient to induce leukemia in animals, suggesting that additional mutations are required for leukemogenesis.     ///    C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice.. 