The ITGA7-TIMP3 binding led to a decreased protein level of tumor necrosis factor ?, cytoplasmic translocation of NF-?B, and down-regulation of cyclin D1.     ///    "Interestingly, knocking down ITGA7 ligand laminin ?1 enhanced ITGA7-TIMP3 signaling and the downstream tumor-suppressor activity, suggesting the existence of a counterbalancing role between extracellular matrix and integrin signaling. "    ///    "Knocking down TIMP3 or ITGA7/TIMP3 binding interference largely abrogated the signaling changes induced by ITGA7, whereas a mutant ITGA7 lacking TIMP3 binding activity had no tumor-suppressor activity. "