Subsequent to CRL-dependent I?B? ubiquitination functional p97/VCP is essentially required for efficient liberation of (phosphorylated) RelA from I?B?, preceding p97/VCP-promoted timely and efficient degradation of I?B? as well as simultaneous NF-?B/RelA nuclear translocation.     ///    "While RelA phosphorylation was observed to mediate NF-?B activation independent of Ub-proteasome-pathway (UPP)-dependent turnover of I?B? in some studies, a strict requirement of the p97/VCP ATPase for both, I?B? degradation and NF-?B activation, was reported in others. "    ///    "Collectively, our data add new facets to the knowledge about maintenance of I?B? and RelA expression, likely depending on p97/VCP-supported scheduled basal NF-?B activity, and the mechanism of TNF-induced NF-?B activation. "    ///    p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of I?B? and the preceding liberation of RelA from ubiquitinated I?B?.. 