 We have analyzed t(12;21)(p13:q22) in an attempt to evaluate the frequency and prognostic significance of TEL-AML1 fusion gene in patients with childhood CD 10 positive B-ALL by fluorescence in situ hybridization (FISH).     ///    Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study..     ///    TEL-AML1 fusion gene was positive in (37.5%) in newly diagnosed patients.     ///    "There was a significant correlation between TEL-AML1 fusion gene both at diagnosis (r = 0.5, P = 0.003) and as a MRD (r = 0.4, P = 0.01) with favorable course. "    ///    "For most patients, the presence of TEL-AML1 fusion gene at diagnosis suggests a favorable prognosis. "    ///    Kaplan-Meier curve for the presence of TEL-AML1 fusion at the diagnosis was associated with a better probability of overall survival (OS).     ///    "So, persistence of TEL-AML1 fusion as a MRD had no additive prognostic value over its measurement at diagnosis in terms of predicting the probability of OS. "    ///    The present study suggests that persistence of TEL-AML1 fusion as MRD has no additive prognostic value..     ///    We determined the prognostic significance of TEL-AML1 fusion represented by disease course and survival.     ///    "Also, the persistence at TEL-AML1 fusion as a MRD was not significantly associated with a better probability of OS. "