In summary, transcriptional repression mediated by AML1-ETO appears to play a mechanistic role in the t(8;21) AML, and relief of repression using agents such as PB (alone or in combination) may prove to be therapeutically useful..     ///    "PB was also able to induce partial differentiation of the AML1-ETO cell line, Kasumi-1. "    ///    "Here, we used inhibitors of HDAC1 to study the pathophysiology of AML1-ETO. "    ///    Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells..     ///    " The (8;21) translocation, found in 12% of acute myeloid leukemia (AML), creates the chimeric fusion product, AML1-ETO. "