 The API2-MALT1 fusion oncoprotein is created by the recurrent t(11;18)(q21;q21) chromosomal translocation in mucosa-associated lymphoid tissue (MALT) lymphoma.     ///    "Furthermore, we found that TNF receptor-associated factor 2 (TRAF2) recruitment is required for API2-MALT1 to induce RIP1 ubiquitination, NF-?B activation and cellular transformation. "    ///    "API2-MALT1 promotes ubiquitination of RIP1 at lysine (K) 377, which is necessary for full NF-?B activation. "    ///    The API2-MALT1 fusion exploits TNFR pathway-associated RIP1 ubiquitination to promote oncogenic NF-?B signaling.. 