Chromosomal RET rearrangements, called RET/PTC, result in constitutive ligand-independent activation of RET kinase, which was the first genetic anomaly detected in PTC and is found in 5-70% of tumoral samples.     ///    Affected elements include RET/PTC rearrangements and point mutations of the Ras and BRAF genes.     ///    "However, no clear association has been found between RET/PTC and clinical features. "