The TLS-CHOP protein consists of the N-terminal half of TLS juxtaposed to the N-terminal of the entire CHOP.     ///    An abnormal extra nuclear localization of PML bodies was also found in TLS-CHOP carrying cell lines established from myxoid liposarcomas.     ///    TLS-CHOP may disturb the nuclear machinery by binding and sequestering important factors from their natural sites..     ///    Transfection of TLS-CHOP to normal fibroblasts causes a rapid down regulation and relocation of PML nuclear bodies.     ///    Transfection of TLS-CHOP induced a rapid disappearance of PCNA.     ///    The myxoid liposarcoma specific TLS-CHOP fusion protein localizes to nuclear structures distinct from PML nuclear bodies.. 