Analysis of patient's primary leukemia blasts revealed that those carrying the t(8;21) generating AML1/ETO, the most common acute myeloid leukemia-associated fusion protein, display low levels of a microRNA-223 (miR-223), a regulator of myelopoiesis.     ///    "Here, we show that miR-223 is a direct transcriptional target of AML1/ETO. "    ///    "By recruiting chromatin remodeling enzymes at an AML1-binding site on the pre-miR-223 gene, AML1/ETO induces heterochromatic silencing of miR-223. "    ///    "Ectopic miR-223 expression, RNAi against AML1/ETO, or demethylating treatment enhances miR-223 levels and restores cell differentiation. "    ///    Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.. 