The t(11;22) encodes the EWS/FLI fusion oncoprotein.     ///    "EWS/FLI functions as an aberrant transcription factor, but the key target genes that are involved in oncogenesis are largely unknown. "    ///    "By combining transcriptional profiling data from three of these lines, we identified a conserved transcriptional response to EWS/FLI. "    ///    The gene that was most reproducibly up-regulated by EWS/FLI was NR0B1.     ///    NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma..     ///    These studies define a new role for NR0B1 in oncogenic transformation and emphasize the utility of analyzing the function of EWS/FLI in Ewing's sarcoma cells..     ///    We validated NR0B1 as an EWS/FLI-dysregulated gene and confirmed its expression in primary human tumor samples.     ///    "To understand the function of EWS/FLI and its targets in a more clinically relevant system, we used retroviral-mediated RNAi to ""knock-down"" the fusion protein in patient-derived Ewing's sarcoma cell lines. "