The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity..     ///    "By contrast to other chimeric proteins that contain TEL's PNT domain, such as TEL-platelet-derived growth factor beta receptor in t(5;12)(q33;p13), MN1-TEL contains the DBD of TEL. "    ///    "The N-terminal MN1 moiety is rich in proline residues and contains two polyglutamine stretches, suggesting that MN1-TEL may act as a deregulated transcription factor. "    ///    The transactivating capacity of MN1-TEL depended on both the DBD of TEL and sequences in MN1.     ///    "We now show that MN1-TEL type I, unlike TEL and MN1, transforms NIH 3T3 cells. "    ///    MN1-TEL contributes to leukemogenesis by a mechanism distinct from that of other chimeric proteins containing TEL..     ///    "Furthermore, we demonstrate that MN1 has transcription activity and that MN1-TEL acts as a chimeric transcription factor on the Moloney sarcoma virus long terminal repeat and a synthetic promoter containing TEL binding sites. "