Patients carrying the AML1-ETO fusion gene exhibit an accumulation of granulocyte precursors in the bone marrow and the blood.     ///     AML1-ETO is one of the most common chromosomal translocation products associated with acute myelogenous leukemia (AML).     ///    "AML1-ETO quickly shuts off scl expression, and restoration of scl expression rescues the effects of AML1-ETO on myeloerythroid progenitor cell fate. "    ///    "Using this highly tractable model, we show that AML1-ETO redirects myeloerythroid progenitor cells that are developmentally programmed to adopt the erythroid cell fate into the granulocytic cell fate. "    ///    AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression..     ///    "Moreover, we identify scl as an early and essential mediator of the effect of AML1-ETO on hematopoietic cell fate. "    ///    Induced AML1-ETO expression in embryonic zebrafish causes a phenotype that recapitulates some aspects of human AML.     ///    "In addition, treatment of AML1-ETO transgenic zebrafish embryos with a histone deacetylase inhibitor, Trichostatin A, restores scl and gata1 expression, and ameliorates the accumulation of granulocytic cells caused by AML1-ETO. "