 The t(2;5)(p23;q35) chromosomal translocation results in the expression of the fusion protein NPM/ALK that when expressed in T-lymphocytes gives rise to anaplastic large cell lymphomas (ALCL).     ///    "Neurolenin B specifically decreased pro-carcinogenic NPM/ALK expression in ALK+ ALCL cells and, via the inhibition of NF-kB signalling, attenuated tumour intra/extravasation into the lymphatics. "    ///    ex Cass was shown to inhibit NPM/ALK expression.     ///    ex Cass inhibits NPM/ALK-driven cell expansion and NF-?B-driven tumour intravasation..     ///    "In vitro treatment of ALCL by neurolenin B suppressed NPM/ALK, JunB and PDGF-R? expression, inhibited the growth of ALCL cells late in M phase, and induced apoptosis via caspase 3 without compromising mitochondrial activity (as a measure of general exogenic toxicity). "