 The t(12;21) translocation is the most common genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) and gives rise to the TEL-AML1 fusion gene.     ///    "Global gene expression profiling of EML1 cells at different stages of B-lymphoid differentiation, compared with EML-TA, identified the interferon (IFN)?/? pathway as a primary target of repression by TEL-AML1. "    ///    Our data provide new insight on TEL-AML1 function and may offer a new therapeutic opportunity for B-ALL.     ///    "Furthermore, treatment of TEL-AML1 expressing cells with IFN?/? was sufficient to overcome the maturation block. "    ///    "The ability of TEL-AML1 to block B-cell differentiation and downregulate the IRF3-IFN?/? pathway was confirmed in mouse and human primary hematopoietic precursor cells (Lin- and CD34+ cells, respectively), and in a patient-derived cell line expressing TEL-AML1 (REH). "    ///    "Many studies on TEL-AML1 describe specific properties of the fusion protein, but a thorough understanding of its function is lacking. "    ///    The TEL-AML1 fusion protein of acute lymphoblastic leukemia modulates IRF3 activity during early B-cell differentiation..     ///    "We exploited a pluripotent hematopoietic stem/progenitor cell line, EML1, and generated a cell line (EML-TA) stably expressing the TEL-AML1 fusion protein. "