Samples of bone marrow or peripheral blood were collected from 95 newly diagnosed ALL children and the TEL-AML1 fusion gene was detected using nested reverse transcription-polymerase chain reaction (RT-PCR).     ///     To determine the incidence of TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia (ALL) and to compare the clinical features between TEL-AML1 positive and negative patients.     ///    The incidence of TEL-AML1 fusion gene in cases of ALL is 21.05%.     ///    "The load of leukemia cells in TEL-AML1 positive patients is significantly smaller than its counterparts, and the blast cells in TEL-AML1 positive patients are more sensitive to prednisone, indicating childhood ALL with TEL-AML1 fusion gene has a favorable prognosis.. "    ///    The ALL patients were stratified into TEL-AML1 positive and negative groups and the clinical features were compared.     ///    Bone marrow examination on day 15 showed no difference in the rate of complete remission between TEL-AML1 positive and negative patients.     ///    "The prednisone sensitivity test showed that all 12 TEL-AML1 positive patients were good responders, while there were 11 prednisone poor responders among 40 negative patients (27.50%, P < 0.05). "    ///    "Among 95 patients, 20 (21.05%) were TEL-AML1 positive. "    ///    The median age of TEL-AML1 positive patients was 5.9 years old and M/F ratio was 1.22:1.     ///    There were significant differences between TEL-AML1 positive and negative patients in hepatomegaly (2.75 cm vs.     ///    [Comparative study on clinical features between TEL-AML1 positive and negative childhood acute lymphoblastic leukemia].. 