TMPRSS2-ERG and SLC45A3-ERG by RT-PCR, FISH, and direct sequencing.     ///    Single TMPRSS2-ERG translocation is associated with low grade PrCa.     ///    "SLC45A3-ERG and TMPRSS2-ERG rearrangements and their association with ERG and PTEN expression and with clinical and pathological features have been analyzed in 80??rCa (PSMAR-Biobank, Barcelona, Spain). "    ///    Concurrent TMPRSS2-ERG and SLC45A3-ERG rearrangements plus PTEN loss are not found in low grade prostate cancer and define an aggressive tumor subset..     ///    "SLC45A3-ERG was found in 25 cases, 20 of them with concurrent TMPRSS2-ERG rearrangement: 11.5% GS??=??6, 22.2% GS??=??7, and 50% GS?????8 tumors (P??=??0.013). "    ///    Single TMPRSS2-ERG was found in 51.6% GS?????7 and 22.2% GS?????8 tumors (P??=??0.027).     ///    Tumors with combined TMPRSS2-ERG/SLC45A3-ERG fusions plus PTEN loss should be excluded from watchful waiting and are candidates for intensive therapy. 