Recently the RAR alpha gene has been demonstrated to be involved in a novel fusion transcript (PLZF/RAR alpha) through a t(11;17) translocation.     ///    Poor response to all-trans retinoic acid therapy in a t(11;17) PLZF/RAR alpha patient..     ///    We describe here the second case of such a patient with a t(11;17)-PLZF/RAR alpha leukemic clone.     ///    These results suggest that the t(11;17) (PLZF/RAR alpha) case of this study was less responsive to ATRA therapy than t(15;17) (PML/RAR alpha) cases and raises the question of the definition of this novel AML subtype.. 