 The chromosomal translocation t(8;21) often found in acute myeloid leukemia generates an oncogenic fusion protein AML1-ETO.     ///    Generation of monoclonal antibodies to the AML1-ETO fusion protein: strategies for overcoming high homology..     ///    This strategy has been validated with the oncogenic fusion protein AML1-ETO involved in acute myeloid leukemia..     ///    Monoclonal antibodies that can capture and detect the AML1-ETO fusion protein would help with early diagnosis and treatment prognosis of acute myeloid leukemia.     ///    These MAbs bound specifically to a recombinant form of AML1-ETO fusion protein expressed in HEK and to an endogenous AML1-ETO form of the fusion protein expressed in Kasumi-1.     ///    This included a process to select antibodies for their ability to also recognize the translocated chromosomal AML1-ETO fusion protein and to identify complementary capture/detector antibody pairs. 