We describe here a case of CML who presented de novo in transformation with a t(9;11)(p21;p15) and NUP98-LEDGF fusion in addition to the t(9;22).     ///    NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia..     ///    This is the first description of NUP98-LEDGF in CML and strengthens the association between disease progression in and NUP98 abnormalities.. 