Western blotting and qRT-PCR analysis showed that protein levels of APP are significantly higher in Kasumi-1, a?t(8;21)/ AML1/ETO-positive M2-type AML cell line.     ///    "These findings indicate that overexpression of APP is involved in promoting proliferation and migration of AML1/ETO-positive leukemia cells and can be inhibited by panobinostat, which provide an attractive prospect for treatment of AML1/ETO-positive AML. "    ///    "In this study, we attempted to define the roles of APP in AML1/ETO-positive leukemia cells. "    ///    Increased expression of amyloid precursor protein promotes proliferation and migration of AML1/ETO-positive leukemia cells and be inhibited by panobinostat..     ///    Previously we found that overexpression of APP in patients with AML1/ETO-positive acute myeloid leukemia (AML) associated with a?higher incidence of extramedullary?infiltrationin and indicate a?poor prognosis. 