We now report that NPM-RAR expression is permissive for TNF activation of NF?B and JNK.     ///    "We have previously shown that NPM-RAR interaction with TRADD blocks TNF activation of caspase 3, caspase 8, poly(ADP-ribose) polymerase (PARP) cleavage and, ultimately, apoptosis. "    ///    "We have previously shown that NPM-RAR is a binding partner of the tumor necrosis factor (TNF) receptor type-I-associated DEATH domain protein, TRADD. "    ///    "We propose that inhibition of TNF activation of apoptosis, while preserving TNF activation of NF?B and JNK pathways that stimulate cell growth and survival, represents a novel mechanism through which NPM-RAR contributes to development of the leukemic phenotype. "    ///    "NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NF?B and JNK.. "