Finally, our findings confirm that additional or secondary genetic changes are commonly encountered in pediatric B-lineage ALL with ETV6-RUNX1 gene fusion which is envisaged to play a pivotal role in disease progression..     ///    This translocation leads ETV6-RUNX1 (previously TEL-AML1) fusion gene.     ///    16 patients (28%) had ETV6-RUNX1 rearrangement.     ///    ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia..     ///    Seven patients without ETV6-RUNX1 rearrangement showed extra signals of the RUNX1 gene. 