 OTT/RBM15-BSAC/MAL/MKL1/MRTF-A was identified as a fusion transcript generated by t(1;22)(p13;q13) in acute megakaryoblastic leukemia.     ///    "In addition, although BSAC predominantly localizes in the cytoplasm and its nuclear translocation is considered to be regulated by the Rho-actin signaling pathway, OTT-BSAC exclusively localizes in the nucleus. "    ///    "Here we show that OTT-BSAC, but not BSAC or OTT strongly activates several promoters containing a transcription factor Yin Yang 1-binding sequence. "    ///    "However, the mechanism by which OTT-BSAC promotes leukemia is largely unknown. "    ///    "Moreover, OTT interacts with histone deacetylase 3, but this interaction is abolished in OTT-BSAC. "