MRD status was the strongest predictor of outcome with 5 year EFS rates greater that 90% seen in those patients with low-risk MRD and this was associated with TEL/AML1 rearrangement, high hyperdiploidy (HH) karyotype and female gender.     ///    "in the late 1960s were most likely composed of low-risk MRD, TEL/AML1 and HH patients.. "