Knockdown of EWS-POU5F1 in the t(6;22) sarcoma-derived GBS6 cell line resulted in a significant decrease of cell proliferation because of G1 cell cycle arrest associated with p27(Kip1) up-regulation.     ///    "In contrast, EWS-POU5F1 down-regulation markedly increased the cell migration and invasion as well as activation of metalloproteinase 2 and metalloproteinase 14. "    ///    Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance..     ///    "To clarify the roles of the EWS-POU5F1 chimera in tumorigenesis and tumor cell maintenance, we used small-interfering RNA-mediated gene silencing. "    ///    "In addition, the EWS-POU5F1 chimeras have been recently identified in human neoplasms of the skin and salivary glands. "