These effects are linked to rearrangements of interprotomer contacts, changes in the mean twist, and filament destabilization by ADF/cofilin.     ///    Our data suggest that ADF/cofilins play an active role in establishing new interprotomer interfaces in F-actin that substitute for disrupted (as in TMR-actin and mutant actin) or weakened (as in ADP-actin) longitudinal contacts in filaments..     ///     ADF/cofilins are abundant actin binding proteins critical to the survival of eukaryotic cells.     ///    "Most ADF/cofilins bind both G and F-actin, sever the filaments and accelerate their treadmilling. "